{"id":"https://openalex.org/W2010404279","doi":"https://doi.org/10.1016/j.canlet.2005.01.023","title":"Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine","display_name":"Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine","publication_year":2005,"publication_date":"2005-03-17","ids":{"openalex":"https://openalex.org/W2010404279","doi":"https://doi.org/10.1016/j.canlet.2005.01.023","mag":"2010404279","pmid":"https://pubmed.ncbi.nlm.nih.gov/16356839"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2005.01.023","doi":"https://doi.org/10.1016/j.canlet.2005.01.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2005.01.023","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110213293","display_name":"Qingsu Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingsu Xia","raw_affiliation_strings":["Division of Biochemical Toxicology, National Center for Toxicological Research, 3,900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Toxicology, National Center for Toxicological Research, 3,900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111483349","display_name":"Ming Wu Chou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming W. Chou","raw_affiliation_strings":["Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052067474","display_name":"John A. Edgar","orcid":"https://orcid.org/0000-0002-7221-0635","observed_orcids":["https://orcid.org/0000-0002-7221-0635"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John A. Edgar","raw_affiliation_strings":["CSIRO Livestock Industries, PB 24, Geelong, Vic. 3220, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIRO Livestock Industries, PB 24, Geelong, Vic. 3220, Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081604382","display_name":"Daniel R. Doerge","orcid":"https://orcid.org/0000-0002-7723-9541","observed_orcids":["https://orcid.org/0000-0002-7723-9541"]},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Doerge","raw_affiliation_strings":["Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069374770","display_name":"Peter P. Fu","orcid":"https://orcid.org/0000-0003-1902-1189","observed_orcids":["https://orcid.org/0000-0003-1902-1189"]},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter P. Fu","raw_affiliation_strings":["Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069374770"],"corresponding_institution_ids":["https://openalex.org/I1304557061"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":1.1294,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.7401646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"231","issue":"1","first_page":"138","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrrolizidine-alkaloids","display_name":"pyrrolizidine alkaloids","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lasiocarpine","display_name":"lasiocarpine","score":0.953000009059906},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/riddelliine","display_name":"riddelliine","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/biomarkers-of-exposure","display_name":"biomarkers of exposure","score":0.8270000219345093},{"id":"https://openalex.org/keywords/alkaloid-metabolism","display_name":"alkaloid metabolism","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2779461572","wikidata":"https://www.wikidata.org/wiki/Q1078442","display_name":"Pyrrolizidine","level":2,"score":0.974357008934021},{"id":"https://openalex.org/C2776074743","wikidata":"https://www.wikidata.org/wiki/Q75005794","display_name":"Pyrrolizidine alkaloid","level":3,"score":0.833659827709198},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.706712543964386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.649789571762085},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.6274620294570923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6073609590530396},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.5407559871673584},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4938676953315735},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.4755266010761261},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4493376612663269},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3664610981941223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3351440727710724},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21976563334465027},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011763","descriptor_name":"Pyrrolizidine Alkaloids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011763","descriptor_name":"Pyrrolizidine Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016686","descriptor_name":"Monocrotaline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D016686","descriptor_name":"Monocrotaline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016686","descriptor_name":"Monocrotaline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.canlet.2005.01.023","doi":"https://doi.org/10.1016/j.canlet.2005.01.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2005.01.023","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:16356839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16356839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W31182665","https://openalex.org/W1538761328","https://openalex.org/W1777842366","https://openalex.org/W1823703597","https://openalex.org/W1988079273","https://openalex.org/W1996485240","https://openalex.org/W2005274749","https://openalex.org/W2015464920","https://openalex.org/W2017879446","https://openalex.org/W2020130804","https://openalex.org/W2031358324","https://openalex.org/W2032694721","https://openalex.org/W2041017582","https://openalex.org/W2051723151","https://openalex.org/W2060026512","https://openalex.org/W2065231730","https://openalex.org/W2092244018","https://openalex.org/W2100347728","https://openalex.org/W2115155704","https://openalex.org/W2156398993","https://openalex.org/W6637986725"],"related_works":["https://openalex.org/W1978955171","https://openalex.org/W1982361349","https://openalex.org/W2092244018","https://openalex.org/W2156398993","https://openalex.org/W3167023181","https://openalex.org/W4404393857","https://openalex.org/W3016430286","https://openalex.org/W2756306824","https://openalex.org/W2945275840","https://openalex.org/W2314607001"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
