{"id":"https://openalex.org/W2010401549","doi":"https://doi.org/10.1089/hum.1998.9.4-541","title":"Adenovirus-Mediated Interleukin-10 Gene Transfer Inhibits Post-Transplant Fibrous Airway Obliteration in an Animal Model of Bronchiolitis Obliterans","display_name":"Adenovirus-Mediated Interleukin-10 Gene Transfer Inhibits Post-Transplant Fibrous Airway Obliteration in an Animal Model of Bronchiolitis Obliterans","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W2010401549","doi":"https://doi.org/10.1089/hum.1998.9.4-541","mag":"2010401549","pmid":"https://pubmed.ncbi.nlm.nih.gov/9525315"},"language":"en","primary_location":{"id":"doi:10.1089/hum.1998.9.4-541","doi":"https://doi.org/10.1089/hum.1998.9.4-541","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.1998.9.4-541","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111225938","display_name":"Annette Boehler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Boehler","raw_affiliation_strings":["Thoracic Surgery Research Laboratory, The Toronto Hospital, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery Research Laboratory, The Toronto Hospital, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038792930","display_name":"Dean W. Chamberlain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Chamberlain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Z. Xing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z. Xing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041519561","display_name":"Arthur S. Slutsky","orcid":"https://orcid.org/0000-0002-6063-3876","observed_orcids":["https://orcid.org/0000-0002-6063-3876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. S. Slutsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065277319","display_name":"Manel Jordana","orcid":"https://orcid.org/0000-0002-5861-5994","observed_orcids":["https://orcid.org/0000-0002-5861-5994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Jordana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005295653","display_name":"Jack Gauldie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Gauldie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709242","display_name":"Mingyao Liu","orcid":"https://orcid.org/0000-0002-9188-8417","observed_orcids":["https://orcid.org/0000-0002-9188-8417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086297813","display_name":"Shaf H Keshavjee","orcid":"https://orcid.org/0000-0003-4547-8094","observed_orcids":["https://orcid.org/0000-0003-4547-8094"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S. Keshavjee","raw_affiliation_strings":["Address reprint requests to: Dr. S. Keshavjee, Division of Thoracic Surgery, The Toronto Hospital, 200 Elizabeth St EN10-224, Toronto, Ontario, Canada M5G 2C4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to: Dr. S. Keshavjee, Division of Thoracic Surgery, The Toronto Hospital, 200 Elizabeth St EN10-224, Toronto, Ontario, Canada M5G 2C4","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086297813"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.7712,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.97671677,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"541","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9829999804496765},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/airway-fibrosis","display_name":"airway fibrosis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/chronic-rejection","display_name":"chronic rejection","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tracheal-allograft","display_name":"tracheal allograft","score":0.8330000042915344},{"id":"https://openalex.org/keywords/th2-polarization","display_name":"Th2 polarization","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2776739411","wikidata":"https://www.wikidata.org/wiki/Q614750","display_name":"Bronchiolitis obliterans","level":4,"score":0.9536194801330566},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6174910068511963},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6019507646560669},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5948208570480347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5418797731399536},{"id":"https://openalex.org/C2778821649","wikidata":"https://www.wikidata.org/wiki/Q424227","display_name":"Bronchiolitis","level":3,"score":0.45980751514434814},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.4275187849998474},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.38679152727127075},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34170758724212646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2534950375556946},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1978949010372162},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1383448839187622},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.12579786777496338},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001989","descriptor_name":"Bronchiolitis Obliterans","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001989","descriptor_name":"Bronchiolitis Obliterans","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001989","descriptor_name":"Bronchiolitis Obliterans","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001989","descriptor_name":"Bronchiolitis Obliterans","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016042","descriptor_name":"Transplantation, Heterotopic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/hum.1998.9.4-541","doi":"https://doi.org/10.1089/hum.1998.9.4-541","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.1998.9.4-541","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:9525315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9525315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306168","display_name":"Cystic Fibrosis Foundation","ror":"https://ror.org/00ax59295"},{"id":"https://openalex.org/F4320314184","display_name":"National Sanitarium Association","ror":"https://ror.org/058wt2b66"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W58919459","https://openalex.org/W268767474","https://openalex.org/W1487269041","https://openalex.org/W1593923919","https://openalex.org/W1670578641","https://openalex.org/W1853090825","https://openalex.org/W1965999876","https://openalex.org/W1972922050","https://openalex.org/W1976488762","https://openalex.org/W1979884741","https://openalex.org/W1981469317","https://openalex.org/W1984669153","https://openalex.org/W1985321490","https://openalex.org/W1987445783","https://openalex.org/W1989374721","https://openalex.org/W2004612937","https://openalex.org/W2005804757","https://openalex.org/W2006327956","https://openalex.org/W2016213088","https://openalex.org/W2018347662","https://openalex.org/W2026426056","https://openalex.org/W2027414566","https://openalex.org/W2027679783","https://openalex.org/W2036134087","https://openalex.org/W2039097331","https://openalex.org/W2052938585","https://openalex.org/W2063825262","https://openalex.org/W2065354528","https://openalex.org/W2073281169","https://openalex.org/W2084990572","https://openalex.org/W2094624090","https://openalex.org/W2098277628","https://openalex.org/W2100369434","https://openalex.org/W2101771134","https://openalex.org/W2110190262","https://openalex.org/W2115954882","https://openalex.org/W2116803825","https://openalex.org/W2133978325","https://openalex.org/W2414412010","https://openalex.org/W2416923622","https://openalex.org/W4210657423","https://openalex.org/W4242103194","https://openalex.org/W4243998405","https://openalex.org/W4301882029"],"related_works":["https://openalex.org/W2049116607","https://openalex.org/W2026343159","https://openalex.org/W2060361910","https://openalex.org/W2036864293","https://openalex.org/W1965580756","https://openalex.org/W2070647506","https://openalex.org/W1999849402","https://openalex.org/W2133978325","https://openalex.org/W2087049361","https://openalex.org/W3211535979"],"abstract_inverted_index":{"Bronchiolitis":[0],"obliterans,":[1,293,339],"a":[2,112,199,203,210,294,305,316,334],"form":[3,82,119,295],"of":[4,13,23,56,127,165,170,190,219,225,231,249,252,258,275,289,296,315,337,351,361,367,386,393],"chronic":[5,297],"allograft":[6,266,298],"rejection":[7,267,299],"characterized":[8],"by":[9,83,87,100,121,358],"progressive":[10],"fibrous":[11,128],"obliteration":[12,130],"the":[14,17,54,76,125,148,163,171,178,188,214,223,243,246,256,287,313,359,362,365,387,390],"airways,":[15],"is":[16,234],"major":[18,220],"obstacle":[19],"limiting":[20],"prolonged":[21],"survival":[22],"lung":[24,301],"transplant":[25,68],"recipients.":[26],"To":[27,285],"date,":[28],"no":[29],"effective":[30],"therapy":[31],"against":[32],"this":[33,194,329,354],"fatal":[34],"complication":[35],"exists.":[36],"Interleukin-10":[37,253],"(IL-10),":[38],"an":[39,59],"anti-inflammatory":[40],"and":[41,48,96,156,236,268,280,370],"immunosuppressive":[42],"cytokine,":[43],"inhibits":[44],"various":[45],"T":[46],"cell":[47,50],"antigen-presenting":[49],"functions.":[51],"We":[52,181],"examined":[53],"effect":[55,212,288,350],"IL-10":[57,72,89,103,115,185,216,290,311,341,352,369,372],"in":[58,79,135,193,222,255,263,353],"animal":[60],"model":[61,69,336],"for":[62,383],"bronchiolitis":[63,227,292,338],"obliterans.":[64,228],"A":[65,167,320],"heterotopic":[66],"tracheal":[67],"was":[70,73,98,144,150,160,174,343,356],"used.":[71],"administered":[74],"to":[75,137,176,208,241,345],"recipient":[77],"either":[78],"its":[80,232],"recombinant":[81,118,368],"osmotic":[84],"minipump":[85],"or":[86,120],"adenoviral-mediated":[88,371],"gene":[90,94,122,172,278,373],"transfer":[91],"(Ad5E1mIL-10).":[92],"Successful":[93],"transfection":[95,197],"expression":[97,279],"confirmed":[99,357],"measuring":[101],"circulating":[102],"protein.":[104],"Tracheal":[105],"allografts":[106],"were":[107],"assessed":[108],"histologically":[109],"based":[110],"on":[111,213,291],"scoring":[113],"system.":[114],"administration":[116,169,233,342,366],"(in":[117],"transfer)":[123],"inhibited":[124],"development":[126,189],"airway":[129,191,347],"3":[131],"weeks":[132],"after":[133,154,300],"transplantation":[134,155],"comparison":[136],"untreated":[138],"controls":[139],"(p":[140],"<":[141],"0.05).":[142],"This":[143],"demonstrated":[145],"only":[146],"if":[147,158],"delivery":[149],"initiated":[151],"5":[152],"days":[153],"not":[157],"it":[159],"started":[161],"at":[162,198],"time":[164],"transplantation.":[166],"single":[168],"construct":[173],"sufficient":[175],"achieve":[177],"desired":[179,211],"effect.":[180],"have":[182],"shown":[183],"that":[184,340,378],"can":[186,205],"prevent":[187],"fibro-obliteration":[192],"model.":[195],"Gene":[196],"site":[200],"distant":[201],"from":[202],"graft":[204],"be":[206,218,261,381],"used":[207,304],"produce":[209],"graft.":[215],"may":[217,380],"importance":[221],"control":[224,314,326],"post-transplant":[226],"The":[229,349],"timing":[230],"critical":[235],"further":[237,384],"studies":[238],"are":[239],"required":[240],"determine":[242],"mechanisms":[244,388],"underlying":[245,389],"observed":[247,391],"effects":[248,392],"IL-10.":[250,394],"Expression":[251],"(IL-10)":[254],"setting":[257],"allotransplantation":[259],"might":[260],"beneficial":[262],"preventing":[264,282],"acute":[265],"has":[269],"recently":[270],"been":[271],"associated":[272],"with":[273,364],"stabilization":[274],"polarized":[276],"Th2-type":[277],"thereby":[281],"Th1-type":[283],"activation.":[284],"explore":[286],"transplantation,":[302],"we":[303,331],"replication-defective":[306,321],"type-5":[307],"adenovirus":[308,322],"encoding":[309],"murine":[310],"under":[312],"cytomegalovirus":[317],"promoter":[318],"(AdE1mIL-10).":[319],"(Ad5d170-3)":[323],"served":[324],"as":[325],"vector.":[327],"In":[328],"paper":[330],"show,":[332],"using":[333],"rat":[335],"able":[344],"inhibit":[346],"fibro-obliteration.":[348],"process":[355],"replication":[360],"results":[363],"transfer.":[374],"These":[375],"data":[376],"suggest":[377],"AdE1mIL-10":[379],"useful":[382],"study":[385]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
