{"id":"https://openalex.org/W2010400984","doi":"https://doi.org/10.1016/j.ajpath.2010.10.023","title":"DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma","display_name":"DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma","publication_year":2011,"publication_date":"2011-01-29","ids":{"openalex":"https://openalex.org/W2010400984","doi":"https://doi.org/10.1016/j.ajpath.2010.10.023","mag":"2010400984","pmid":"https://pubmed.ncbi.nlm.nih.gov/21281797","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3069978"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajpath.2010.10.023","doi":"https://doi.org/10.1016/j.ajpath.2010.10.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2010.10.023","pdf_url":"http://ajp.amjpathol.org/article/S0002944010001161/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://ajp.amjpathol.org/article/S0002944010001161/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100332477","display_name":"Hongyan Liu","orcid":"https://orcid.org/0000-0003-2008-1787","observed_orcids":["https://orcid.org/0000-0003-2008-1787"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyan Liu","raw_affiliation_strings":["Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA","Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010208196","display_name":"Hui\u2010Jia Dong","orcid":"https://orcid.org/0000-0003-2494-8392","observed_orcids":["https://orcid.org/0000-0003-2494-8392"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huijia Dong","raw_affiliation_strings":["Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077746203","display_name":"Keith D. Robertson","orcid":"https://orcid.org/0000-0002-7508-3328","observed_orcids":["https://orcid.org/0000-0002-7508-3328"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Robertson","raw_affiliation_strings":["Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100322216","display_name":"Chen Liu","orcid":"https://orcid.org/0009-0003-0430-6146","observed_orcids":["https://orcid.org/0009-0003-0430-6146","https://orcid.org/0009-0008-6552-1719"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chen Liu","raw_affiliation_strings":["Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100322216"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":2.5943,"has_fulltext":true,"cited_by_count":128,"citation_normalized_percentile":{"value":0.90098958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"178","issue":"2","first_page":"652","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cps1","display_name":"CPS1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/urea-cycle","display_name":"urea cycle","score":0.8820000290870667},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cpg-dinucleotides","display_name":"CpG","score":0.9599999785423279},{"id":"https://openalex.org/keywords/5-azacytidine-demethylation","display_name":"5-azacytidine demethylation","score":0.890999972820282},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hepatocyte-paraffin-1","display_name":"hepatocyte paraffin 1","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6110000014305115},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7511636018753052},{"id":"https://openalex.org/C77061444","wikidata":"https://www.wikidata.org/wiki/Q595994","display_name":"Urea cycle","level":4,"score":0.7303056120872498},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6911165714263916},{"id":"https://openalex.org/C74539022","wikidata":"https://www.wikidata.org/wiki/Q5037840","display_name":"Carbamoyl phosphate synthetase","level":3,"score":0.6413973569869995},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6291048526763916},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6278881430625916},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5831863880157471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5658249855041504},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5298535823822021},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5009400844573975},{"id":"https://openalex.org/C2908748535","wikidata":"https://www.wikidata.org/wiki/Q424409","display_name":"Carbamyl Phosphate","level":3,"score":0.44310688972473145},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4189216196537018},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3845444321632385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3634006381034851},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33223024010658264},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20054084062576294},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.0713299810886383},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002222","descriptor_name":"Carbamoyl-Phosphate Synthase (Ammonia)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002222","descriptor_name":"Carbamoyl-Phosphate Synthase (Ammonia)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051542","descriptor_name":"Hepatocyte Nuclear Factor 3-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051542","descriptor_name":"Hepatocyte Nuclear Factor 3-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ajpath.2010.10.023","doi":"https://doi.org/10.1016/j.ajpath.2010.10.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2010.10.023","pdf_url":"http://ajp.amjpathol.org/article/S0002944010001161/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3069978","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3069978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:21281797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21281797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ajpath.2010.10.023","doi":"https://doi.org/10.1016/j.ajpath.2010.10.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2010.10.023","pdf_url":"http://ajp.amjpathol.org/article/S0002944010001161/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1744230615","display_name":"Molecular Target for Liver Cancer Diagnosis and Therapy","funder_award_id":"R01CA133086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5628681588","display_name":"Mouse Immunopathology","funder_award_id":"K26RR023976","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010400984.pdf","grobid_xml":"https://content.openalex.org/works/W2010400984.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1504303645","https://openalex.org/W1518096844","https://openalex.org/W1543455908","https://openalex.org/W1573205502","https://openalex.org/W1977836335","https://openalex.org/W2001115136","https://openalex.org/W2011030190","https://openalex.org/W2021017345","https://openalex.org/W2023444064","https://openalex.org/W2024615579","https://openalex.org/W2036986058","https://openalex.org/W2041312593","https://openalex.org/W2046980861","https://openalex.org/W2055460924","https://openalex.org/W2059750004","https://openalex.org/W2060916218","https://openalex.org/W2073020691","https://openalex.org/W2084620241","https://openalex.org/W2086382188","https://openalex.org/W2087083968","https://openalex.org/W2108161900","https://openalex.org/W2123400162","https://openalex.org/W2136492640","https://openalex.org/W2145462268","https://openalex.org/W2162117160","https://openalex.org/W2178289462","https://openalex.org/W2415125453","https://openalex.org/W4211090232"],"related_works":["https://openalex.org/W3173755413","https://openalex.org/W2055251807","https://openalex.org/W2315485056","https://openalex.org/W2153671139","https://openalex.org/W2211493305","https://openalex.org/W4403300340","https://openalex.org/W1515195996","https://openalex.org/W2088203127","https://openalex.org/W1987276801","https://openalex.org/W1537112530"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}