{"id":"https://openalex.org/W2010388401","doi":"https://doi.org/10.1074/jbc.m207518200","title":"Casein Kinase 2 Interacts with Cyclin-dependent Kinase 11 (CDK11) in Vivo and Phosphorylates Both the RNA Polymerase II Carboxyl-terminal Domain and CDK11 in Vitro","display_name":"Casein Kinase 2 Interacts with Cyclin-dependent Kinase 11 (CDK11) in Vivo and Phosphorylates Both the RNA Polymerase II Carboxyl-terminal Domain and CDK11 in Vitro","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2010388401","doi":"https://doi.org/10.1074/jbc.m207518200","mag":"2010388401","pmid":"https://pubmed.ncbi.nlm.nih.gov/12429741"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m207518200","doi":"https://doi.org/10.1074/jbc.m207518200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m207518200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m207518200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032908029","display_name":"Janeen H. Trembley","orcid":"https://orcid.org/0000-0003-3597-2611","observed_orcids":["https://orcid.org/0000-0003-3597-2611"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janeen H. Trembley","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048752992","display_name":"Dongli Hu","orcid":"https://orcid.org/0000-0001-5716-2084","observed_orcids":["https://orcid.org/0000-0001-5716-2084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dongli Hu","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, Memphis, Tennessee 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, Memphis, Tennessee 38105","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111689239","display_name":"Clive Arthur Slaughter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clive A. Slaughter","raw_affiliation_strings":["Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052921260","display_name":"Jill M. Lahti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill M. Lahti","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, Memphis, Tennessee 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, Memphis, Tennessee 38105","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041113103","display_name":"Vincent J. Kidd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vincent J. Kidd","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, Memphis, Tennessee 38105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, Memphis, Tennessee 38105","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041113103"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.9799,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.85821013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"278","issue":"4","first_page":"2265","last_page":"2270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.1324000060558319,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07169999927282333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/casein-kinase-2","display_name":"casein kinase 2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cdk11","display_name":"CDK11","score":0.8309999704360962},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/transcription","display_name":"transcription","score":0.47600001096725464},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.9120000004768372},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.6179999709129333},{"id":"https://openalex.org/keywords/kinase-isoforms","display_name":"kinase isoforms","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C205744416","wikidata":"https://www.wikidata.org/wiki/Q18248555","display_name":"Casein kinase 2, alpha 1","level":5,"score":0.688491702079773},{"id":"https://openalex.org/C143910341","wikidata":"https://www.wikidata.org/wiki/Q21102140","display_name":"Casein kinase 2","level":5,"score":0.6639858484268188},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.5675731301307678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5384798645973206},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.5340508222579956},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45743587613105774},{"id":"https://openalex.org/C160110348","wikidata":"https://www.wikidata.org/wiki/Q5048387","display_name":"Casein kinase 1","level":4,"score":0.44655221700668335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44466179609298706},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4395485818386078},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.42432835698127747},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3940388262271881},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3212518095970154},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12168583273887634},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.12148335576057434},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06647583842277527},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047390","descriptor_name":"Casein Kinase II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m207518200","doi":"https://doi.org/10.1074/jbc.m207518200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m207518200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12429741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12429741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m207518200","doi":"https://doi.org/10.1074/jbc.m207518200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m207518200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G308998970","display_name":"Functional Analysis of CDKp110 Protein Kinase","funder_award_id":"R01GM044088","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1525575010","https://openalex.org/W1531173607","https://openalex.org/W1532893184","https://openalex.org/W1556616823","https://openalex.org/W1560464036","https://openalex.org/W1578955626","https://openalex.org/W1677175288","https://openalex.org/W1969939692","https://openalex.org/W1982960071","https://openalex.org/W1988904557","https://openalex.org/W1993243592","https://openalex.org/W1993246806","https://openalex.org/W2004408181","https://openalex.org/W2004828705","https://openalex.org/W2019850601","https://openalex.org/W2022945123","https://openalex.org/W2029047331","https://openalex.org/W2032562294","https://openalex.org/W2036904418","https://openalex.org/W2038407368","https://openalex.org/W2050041795","https://openalex.org/W2052221882","https://openalex.org/W2064050024","https://openalex.org/W2083078196","https://openalex.org/W2091250415","https://openalex.org/W2105420135","https://openalex.org/W2107594198","https://openalex.org/W2137357847","https://openalex.org/W2418361432","https://openalex.org/W4231142846","https://openalex.org/W4238443999"],"related_works":["https://openalex.org/W2031486619","https://openalex.org/W4417274113","https://openalex.org/W2022945123","https://openalex.org/W4396829159","https://openalex.org/W2109885069","https://openalex.org/W7098558882","https://openalex.org/W3028287471","https://openalex.org/W1998812756","https://openalex.org/W4412110418","https://openalex.org/W2063970781"],"abstract_inverted_index":{"The":[0],"PITSLRE":[1],"protein":[2,25,75,90],"kinases,":[3],"hereafter":[4],"referred":[5],"to":[6,13,107,138],"as":[7,34,36,94],"cyclin-dependent":[8],"kinase":[9,76,91,96],"11":[10],"(CDK11)":[11],"due":[12],"their":[14],"association":[15],"with":[16,80],"cyclin":[17],"L,":[18],"are":[19],"part":[20],"of":[21,50,60,142,154],"large":[22],"molecular":[23],"weight":[24],"complexes":[26],"that":[27,47,78,122,129,133],"contain":[28],"RNA":[29,40,143,160],"polymerase":[30],"II":[31,63,110],"(RNAP":[32],"II)":[33],"well":[35],"numerous":[37],"transcription":[38,53,144,161],"and":[39,54,73,85,101,132,145],"processing":[41,146,163],"factors.":[42],"Data":[43],"presented":[44],"here":[45],"demonstrate":[46],"the":[48,61,108,115,140],"influence":[49],"CDK11(p110)":[51,81,116,123,155],"on":[52],"splicing":[55],"does":[56],"not":[57],"involve":[58],"phosphorylation":[59,153],"RNAP":[62,109],"carboxyl-terminal":[64,111],"domain":[65],"by":[66,99,156],"CDK11(p110).":[67],"We":[68],"have":[69],"isolated":[70],"a":[71],"DRB-":[72],"heparin-sensitive":[74],"activity":[77],"co-purifies":[79],"after":[82],"ion":[83],"exchange":[84],"affinity":[86],"purification":[87],"chromatography.":[88],"This":[89],"was":[92],"identified":[93],"casein":[95],"2":[97],"(CK2)":[98],"immunoblot":[100],"mass":[102],"spectrometry":[103],"analyses.":[104],"In":[105],"addition":[106],"domain,":[112],"CK2":[113,131,157],"phosphorylates":[114],"amino-terminal":[117],"domain.":[118],"These":[119],"data":[120],"suggest":[121],"isoforms":[124],"participate":[125],"in":[126],"signaling":[127],"pathways":[128],"include":[130],"its":[134],"function":[135],"may":[136],"help":[137],"coordinate":[139],"regulation":[141],"events.":[147,164],"Future":[148],"experiments":[149],"will":[150],"determine":[151],"how":[152],"specifically":[158],"affects":[159],"and/or":[162]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}