{"id":"https://openalex.org/W2010368497","doi":"https://doi.org/10.1097/00003072-199201000-00012","title":"Safety and Efficacy of Repeated Sequential Administrations of Re-186(Sn)HEDP as Palliative Therapy for Painful Skeletal Metastases","display_name":"Safety and Efficacy of Repeated Sequential Administrations of Re-186(Sn)HEDP as Palliative Therapy for Painful Skeletal Metastases","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2010368497","doi":"https://doi.org/10.1097/00003072-199201000-00012","mag":"2010368497","pmid":"https://pubmed.ncbi.nlm.nih.gov/1371956"},"language":"en","primary_location":{"id":"doi:10.1097/00003072-199201000-00012","doi":"https://doi.org/10.1097/00003072-199201000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003072-199201000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S1118231","display_name":"Clinical Nuclear Medicine","issn_l":"0363-9762","issn":["0363-9762","1536-0229"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087143114","display_name":"Emanuela Englaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"EMANUELA E. ENGLARO","raw_affiliation_strings":["Eugene L. Saenger Radioisotope Laboratory, University of Cincinnati Medical Center, Ohio 45267-0577"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eugene L. Saenger Radioisotope Laboratory, University of Cincinnati Medical Center, Ohio 45267-0577","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073937541","display_name":"Louis E. Schroder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LOUIS E. SCHRODER","raw_affiliation_strings":["From the Department of Radiology, and the Division of Hematology-Oncology/Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiology, and the Division of Hematology-Oncology/Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":null,"display_name":"STEPHEN R. THOMAS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"STEPHEN R. THOMAS","raw_affiliation_strings":["From the Division of Medical Physics, University of Cincinnati Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Medical Physics, University of Cincinnati Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108602721","display_name":"Craig C. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"CRAIG C. WILLIAMS","raw_affiliation_strings":["From the Eugene L Saenger Radioisotope Laboratory, University of Cincinnati Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Eugene L Saenger Radioisotope Laboratory, University of Cincinnati Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052714864","display_name":"Harry R. Maxon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"HARRY R. MAXON","raw_affiliation_strings":["From the Eugene L Saenger Radioisotope Laboratory, University of Cincinnati Medical Center, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Eugene L Saenger Radioisotope Laboratory, University of Cincinnati Medical Center, Cincinnati, Ohio","institution_ids":["https://openalex.org/I92156820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052714864","https://openalex.org/A5087143114","https://openalex.org/A5108602721"],"corresponding_institution_ids":["https://openalex.org/I92156820"],"apc_list":null,"apc_paid":null,"fwci":0.4565,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.66644762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"17","issue":"1","first_page":"41","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.06350000202655792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhenium-186","display_name":"rhenium-186","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7649999856948853},{"id":"https://openalex.org/keywords/palliative-radiotherapy","display_name":"palliative radiotherapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6110000014305115},{"id":"https://openalex.org/keywords/analgesic-use","display_name":"analgesic use","score":0.8450000286102295},{"id":"https://openalex.org/keywords/platelet-count-decline","display_name":"platelet count decline","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9826240539550781},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6121821999549866},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5398513674736023},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.499666690826416},{"id":"https://openalex.org/C2994186709","wikidata":"https://www.wikidata.org/wiki/Q29483","display_name":"Palliative care","level":2,"score":0.46815088391304016},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.448343962430954},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32312244176864624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30455225706100464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30135947465896606},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010148","descriptor_name":"Intractable Pain","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010166","descriptor_name":"Palliative Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012968","descriptor_name":"Etidronic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00003072-199201000-00012","doi":"https://doi.org/10.1097/00003072-199201000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003072-199201000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S1118231","display_name":"Clinical Nuclear Medicine","issn_l":"0363-9762","issn":["0363-9762","1536-0229"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nuclear Medicine","raw_type":"journal-article"},{"id":"pmid:1371956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1371956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical nuclear medicine","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G6185618512","display_name":"EFFICACIOUS SKELETAL IMAGING RADIOPHARMACEUTICALS","funder_award_id":"R01CA032863","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6996684480","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000068","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2323616944","https://openalex.org/W2126462050","https://openalex.org/W3188611749","https://openalex.org/W2059342531","https://openalex.org/W2086584876","https://openalex.org/W2024582134","https://openalex.org/W2439238670","https://openalex.org/W2054109309","https://openalex.org/W2058924331","https://openalex.org/W40339233"],"abstract_inverted_index":{"Single":[0],"intravenous":[1],"injections":[2,51],"of":[3,12,22,33,52],"30":[4],"to":[5,9,18,49],"35":[6],"mCi":[7],"(1,110":[8],"1,295":[10],"MBq)":[11],"Re-186(Sn)HEDP":[13,37,53],"previously":[14],"have":[15,40],"been":[16],"shown":[17],"result":[19],"in":[20,62,80],"palliation":[21],"painful":[23],"skeletal":[24],"metastases":[25],"from":[26],"prostate":[27],"cancer.":[28],"There":[29],"are":[30],"no":[31],"reports":[32],"patients":[34,44],"receiving":[35],"repetitive":[36],"therapy.":[38],"We":[39],"followed":[41],"two":[42],"such":[43],"who":[45],"received":[46],"multiple":[47],"(five":[48],"seven)":[50],"at":[54],"2-month":[55],"intervals.":[56],"Each":[57],"experienced":[58],"a":[59,76],"sustained":[60],"decrease":[61],"both":[63],"pain":[64],"and":[65],"analgesic":[66],"intake.":[67],"The":[68],"only":[69],"evident":[70],"clinical":[71],"or":[72],"biochemical":[73],"toxicity":[74],"was":[75],"mild":[77],"progressive":[78],"decline":[79],"their":[81],"total":[82],"platelet":[83],"counts.":[84]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
