{"id":"https://openalex.org/W2010368308","doi":"https://doi.org/10.1038/nature13309","title":"c-kit+ cells minimally contribute cardiomyocytes to the heart","display_name":"c-kit+ cells minimally contribute cardiomyocytes to the heart","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W2010368308","doi":"https://doi.org/10.1038/nature13309","mag":"2010368308","pmid":"https://pubmed.ncbi.nlm.nih.gov/24805242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4127035"},"language":"en","primary_location":{"id":"doi:10.1038/nature13309","doi":"https://doi.org/10.1038/nature13309","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature13309","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4127035/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069257867","display_name":"Jop H. van Berlo","orcid":"https://orcid.org/0000-0001-9229-4429","observed_orcids":["https://orcid.org/0000-0001-9229-4429"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jop H. van Berlo","raw_affiliation_strings":["1] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA [2] Department of Medicine, division of Cardiology, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA [3]","Department of Medicine, division of Cardiology, Lillehei Heart Institute, University of Minnesota, Minneapolis, 55455, Minnesota, USA","Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA [2] Department of Medicine, division of Cardiology, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA [3]","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Medicine, division of Cardiology, Lillehei Heart Institute, University of Minnesota, Minneapolis, 55455, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088035027","display_name":"Onur Kanisicak","orcid":"https://orcid.org/0000-0002-8393-4874","observed_orcids":["https://orcid.org/0000-0002-8393-4874"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Onur Kanisicak","raw_affiliation_strings":["1] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA [2]","Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA [2]","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109271296","display_name":"Marjorie Maillet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marjorie Maillet","raw_affiliation_strings":["Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003567291","display_name":"Ronald J. Vagnozzi","orcid":"https://orcid.org/0000-0002-8027-1809","observed_orcids":["https://orcid.org/0000-0002-8027-1809"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald J. Vagnozzi","raw_affiliation_strings":["Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032442021","display_name":"Jason M. Karch","orcid":"https://orcid.org/0000-0002-3023-7469","observed_orcids":["https://orcid.org/0000-0002-3023-7469"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Karch","raw_affiliation_strings":["Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081625238","display_name":"Suh\u2010Chin J. Lin","orcid":"https://orcid.org/0000-0002-4704-8576","observed_orcids":["https://orcid.org/0000-0002-4704-8576"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suh-Chin J. Lin","raw_affiliation_strings":["Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028789598","display_name":"Ryan Middleton","orcid":"https://orcid.org/0000-0002-1293-5896","observed_orcids":["https://orcid.org/0000-0002-1293-5896"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan C. Middleton","raw_affiliation_strings":["Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, California 90048, USA","Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, 90048, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, California 90048, USA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, 90048, California, USA","institution_ids":["https://openalex.org/I4210141674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046381230","display_name":"Eduardo Marb\u00e1n","orcid":"https://orcid.org/0000-0002-3863-280X","observed_orcids":["https://orcid.org/0000-0002-3863-280X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Marb\u00e1n","raw_affiliation_strings":["Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, California 90048, USA","Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, 90048, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, California 90048, USA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]},{"raw_affiliation_string":"Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, 90048, California, USA","institution_ids":["https://openalex.org/I4210141674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075550603","display_name":"Jeffery D. Molkentin","orcid":"https://orcid.org/0000-0002-3558-6529","observed_orcids":["https://orcid.org/0000-0002-3558-6529"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffery D. Molkentin","raw_affiliation_strings":["1] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA [2] Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA [2] Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229, Ohio, USA","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5075550603"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I1344073410"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":35.194,"has_fulltext":false,"cited_by_count":822,"citation_normalized_percentile":{"value":0.99917356,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"509","issue":"7500","first_page":"337","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-kit-cells","display_name":"c-kit+ cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cardiac-progenitor-cells","display_name":"cardiac progenitor cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cardiac-endothelial-cells","display_name":"cardiac endothelial cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cardiac-injury","display_name":"cardiac injury","score":0.6259999871253967},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.7009999752044678},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.40400001406669617},{"id":"https://openalex.org/keywords/cell-fusion","display_name":"cell fusion","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cre-recombinase","display_name":"Cre recombinase","score":0.6859999895095825},{"id":"https://openalex.org/keywords/chimeric-mice","display_name":"chimeric mice","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.7046620845794678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6007532477378845},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6006706953048706},{"id":"https://openalex.org/C125929170","wikidata":"https://www.wikidata.org/wiki/Q908966","display_name":"Cre recombinase","level":5,"score":0.5773752927780151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48548534512519836},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.44383183121681213},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.44046691060066223},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32418107986450195},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2285623550415039},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21301087737083435},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1957707405090332},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.11731234192848206},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.09995928406715393}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D006335","descriptor_name":"Heart Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032386","descriptor_name":"Myoblasts, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D032386","descriptor_name":"Myoblasts, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/nature13309","doi":"https://doi.org/10.1038/nature13309","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature13309","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:24805242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24805242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4127035","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4127035/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.805.5690","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.805.5690","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9d/dd/nihms583195.PMC4127035.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:nat:nature:v:509:y:2014:i:7500:d:10.1038_nature13309","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature13309","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4127035","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4127035/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2372146560","display_name":"Functional relevance of cardiac regeneration by c-kit positive stem cells","funder_award_id":"R00HL112852","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6710817820","display_name":"SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE","funder_award_id":"P50HL052318","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6727582741","display_name":"Improving Cardiac Function After Myocardial Infarction","funder_award_id":"P01HL108806","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7094166147","display_name":"Genetic and Molecular Signaling in Heart Failure","funder_award_id":"P50HL077101","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7525386534","display_name":"Molecular Pathways Controlling Cardiac Gene Expression","funder_award_id":"R37HL060562","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000883745","display_name":"Thrombospondin 4 regulates adaptive ER stress responseRenewal - Resubmission - 1","funder_award_id":"R01HL105924","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1255140582","https://openalex.org/W1588023497","https://openalex.org/W1631250427","https://openalex.org/W1869970828","https://openalex.org/W1973637933","https://openalex.org/W1989062603","https://openalex.org/W1991374176","https://openalex.org/W2006252350","https://openalex.org/W2016823790","https://openalex.org/W2028036560","https://openalex.org/W2050950457","https://openalex.org/W2055323054","https://openalex.org/W2055571680","https://openalex.org/W2067009965","https://openalex.org/W2067576098","https://openalex.org/W2068380542","https://openalex.org/W2086176700","https://openalex.org/W2086941834","https://openalex.org/W2090041902","https://openalex.org/W2093494581","https://openalex.org/W2096990057","https://openalex.org/W2097834438","https://openalex.org/W2101986300","https://openalex.org/W2104206289","https://openalex.org/W2117819494","https://openalex.org/W2118131344","https://openalex.org/W2122059700","https://openalex.org/W2132735690","https://openalex.org/W2139284714","https://openalex.org/W2148402694","https://openalex.org/W2155647086","https://openalex.org/W2159630741","https://openalex.org/W2160776258","https://openalex.org/W4211016865"],"related_works":["https://openalex.org/W2254879660","https://openalex.org/W2792878061","https://openalex.org/W2258847308","https://openalex.org/W2624024365","https://openalex.org/W2799903110","https://openalex.org/W193381145","https://openalex.org/W2949621837","https://openalex.org/W7100882081","https://openalex.org/W2067009965","https://openalex.org/W2909224962"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":26},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":40},{"year":2022,"cited_by_count":57},{"year":2021,"cited_by_count":60},{"year":2020,"cited_by_count":81},{"year":2019,"cited_by_count":70},{"year":2018,"cited_by_count":101},{"year":2017,"cited_by_count":90},{"year":2016,"cited_by_count":104},{"year":2015,"cited_by_count":104},{"year":2014,"cited_by_count":40},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}