{"id":"https://openalex.org/W2010361035","doi":"https://doi.org/10.1021/ja050310n","title":"PEG- and Peptide-Grafted Aliphatic Polyesters by Click Chemistry","display_name":"PEG- and Peptide-Grafted Aliphatic Polyesters by Click Chemistry","publication_year":2005,"publication_date":"2005-04-29","ids":{"openalex":"https://openalex.org/W2010361035","doi":"https://doi.org/10.1021/ja050310n","mag":"2010361035","pmid":"https://pubmed.ncbi.nlm.nih.gov/15898789"},"language":"en","primary_location":{"id":"doi:10.1021/ja050310n","doi":"https://doi.org/10.1021/ja050310n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja050310n","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014575447","display_name":"Bryan Parrish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Parrish","raw_affiliation_strings":["Contribution from the Polymer Science & Engineering Department, University of Massachusetts, Conte Center for Polymer Research, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Polymer Science & Engineering Department, University of Massachusetts, Conte Center for Polymer Research, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055563628","display_name":"Rebecca B. Breitenkamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca B. Breitenkamp","raw_affiliation_strings":["Contribution from the Polymer Science & Engineering Department, University of Massachusetts, Conte Center for Polymer Research, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Polymer Science & Engineering Department, University of Massachusetts, Conte Center for Polymer Research, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030195131","display_name":"Todd S. Emrick","orcid":"https://orcid.org/0000-0003-0460-1797","observed_orcids":["https://orcid.org/0000-0003-0460-1797"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Emrick","raw_affiliation_strings":["Contribution from the Polymer Science & Engineering Department, University of Massachusetts, Conte Center for Polymer Research, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Polymer Science & Engineering Department, University of Massachusetts, Conte Center for Polymer Research, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":27.3919,"has_fulltext":false,"cited_by_count":579,"citation_normalized_percentile":{"value":0.99949064,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"127","issue":"20","first_page":"7404","last_page":"7410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aliphatic-polyesters","display_name":"aliphatic polyesters","score":0.9980000257492065},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.6370000243186951},{"id":"https://openalex.org/keywords/azide-alkyne-cycloaddition","display_name":"azide-alkyne cycloaddition","score":0.9300000071525574},{"id":"https://openalex.org/keywords/polyethylene-glycol-grafting","display_name":"poly(ethylene glycol) grafting","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ring-opening-polymerization","display_name":"ring-opening polymerization","score":0.7390000224113464},{"id":"https://openalex.org/keywords/ring-opening-copolymerization","display_name":"ring-opening copolymerization","score":0.9340000152587891},{"id":"https://openalex.org/keywords/epsilon-caprolactone","display_name":"\u03b5-caprolactone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amphiphilic-polymers","display_name":"amphiphilic polymers","score":0.8859999775886536},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C119394753","wikidata":"https://www.wikidata.org/wiki/Q188245","display_name":"Polyester","level":2,"score":0.9051077961921692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8327332735061646},{"id":"https://openalex.org/C69610077","wikidata":"https://www.wikidata.org/wiki/Q912270","display_name":"Click chemistry","level":2,"score":0.748945951461792},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.662264883518219},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.6524540185928345},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.5553264021873474},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.5074381232261658},{"id":"https://openalex.org/C203897987","wikidata":"https://www.wikidata.org/wiki/Q900770","display_name":"Ring-opening polymerization","level":4,"score":0.5010406970977783},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.49913477897644043},{"id":"https://openalex.org/C2775937945","wikidata":"https://www.wikidata.org/wiki/Q222958","display_name":"Grafting","level":3,"score":0.48830509185791016},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4487801194190979},{"id":"https://openalex.org/C2780437523","wikidata":"https://www.wikidata.org/wiki/Q422660","display_name":"Propargyl","level":3,"score":0.43983569741249084},{"id":"https://openalex.org/C2777517455","wikidata":"https://www.wikidata.org/wiki/Q133145","display_name":"Acetylene","level":2,"score":0.41592273116111755},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1631852090358734},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.15734103322029114}],"mesh":[{"descriptor_ui":"D000114","descriptor_name":"Acetylene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000114","descriptor_name":"Acetylene","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/ja050310n","doi":"https://doi.org/10.1021/ja050310n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja050310n","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:15898789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15898789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.umass.edu:pse_faculty_pubs-1281","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umass.edu/pse_faculty_pubs/282","pdf_url":null,"source":{"id":"https://openalex.org/S4306402240","display_name":"ScholarWorks@UMassAmherst (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Polymer Science and Engineering Department Faculty Publication Series","raw_type":"text"},{"id":"pmh:oai:scholarworks.umass.edu:20.500.14394/41596","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14394/41596","pdf_url":null,"source":{"id":"https://openalex.org/S4306402057","display_name":"Scholarworks (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5461245488","display_name":"Chemistry Biology Interface Predoctoral Training Grant","funder_award_id":"T32GM008515","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1278793486","https://openalex.org/W1964293586","https://openalex.org/W1990990305","https://openalex.org/W1992348051","https://openalex.org/W1997246078","https://openalex.org/W2000886827","https://openalex.org/W2002644771","https://openalex.org/W2006827675","https://openalex.org/W2013070822","https://openalex.org/W2016750917","https://openalex.org/W2029255146","https://openalex.org/W2034387102","https://openalex.org/W2043685554","https://openalex.org/W2061840262","https://openalex.org/W2076735769","https://openalex.org/W2090084294","https://openalex.org/W2099956259","https://openalex.org/W2102127270","https://openalex.org/W2122209896","https://openalex.org/W2127407037","https://openalex.org/W2145662716","https://openalex.org/W4300534146"],"related_works":["https://openalex.org/W2231332572","https://openalex.org/W749517215","https://openalex.org/W2246364916","https://openalex.org/W2083415276","https://openalex.org/W2369554743","https://openalex.org/W2317604491","https://openalex.org/W2107547314","https://openalex.org/W2129919487","https://openalex.org/W2246301985","https://openalex.org/W2158150270"],"abstract_inverted_index":{"Novel":[0],"aliphatic":[1,37,88],"polyesters":[2,38,93],"with":[3,54,61,70],"pendent":[4],"acetylene":[5,41],"groups":[6],"were":[7],"prepared":[8,94],"by":[9,23,48,103],"controlled":[10],"ring-opening":[11,49],"polymerization":[12],"and":[13,20,29],"subsequently":[14],"used":[15],"for":[16,81,111],"grafting":[17,82],"poly(ethylene":[18],"glycol)":[19],"oligopeptide":[21],"moieties":[22],"the":[24,57,62,71],"Cu(I)-catalyzed":[25],"addition":[26],"of":[27,33,51,85,114],"azides":[28],"alkynes,":[30],"a":[31,77,112],"type":[32],"\"click\"":[34],"chemistry.":[35],"These":[36],"possess":[39],"an":[40],"graft":[42,92],"density":[43],"that":[44],"can":[45],"be":[46,68,101],"tailored":[47],"copolymerization":[50],"alpha-propargyl-delta-valerolactone":[52],"(1)":[53],"epsilon-caprolactone.":[55],"Since":[56],"mild":[58],"conditions":[59],"associated":[60],"click":[63],"reaction":[64],"are":[65,98],"shown":[66,99],"to":[67,100],"compatible":[69],"polyester":[72],"backbone,":[73],"this":[74,96],"method":[75],"is":[76],"generally":[78],"useful":[79],"means":[80],"numerous":[83],"types":[84],"functionality":[86],"onto":[87],"polyesters.":[89],"The":[90],"amphiphilic":[91],"in":[95,104],"study":[97],"biocompatible":[102],"vitro":[105],"cytotoxicity":[106],"evaluation,":[107],"suggesting":[108],"their":[109],"suitability":[110],"range":[113],"biomaterial":[115],"applications.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":35},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":57}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}