{"id":"https://openalex.org/W2010356902","doi":"https://doi.org/10.1038/clpt.1987.193","title":"Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans","display_name":"Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans","publication_year":1987,"publication_date":"1987-11-01","ids":{"openalex":"https://openalex.org/W2010356902","doi":"https://doi.org/10.1038/clpt.1987.193","mag":"2010356902","pmid":"https://pubmed.ncbi.nlm.nih.gov/3677542"},"language":"en","primary_location":{"id":"doi:10.1038/clpt.1987.193","doi":"https://doi.org/10.1038/clpt.1987.193","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1987.193","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047227576","display_name":"Adam F. Cohen","orcid":"https://orcid.org/0000-0001-7452-6222","observed_orcids":["https://orcid.org/0000-0001-7452-6222","https://orcid.org/0009-0003-6971-7392"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":true,"raw_author_name":"A F Cohen","raw_affiliation_strings":["Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham, Kent, UK","Centre for Bio-Pharmaceutical Sciences, Leiden","Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham, Kent, UK","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"Centre for Bio-Pharmaceutical Sciences, Leiden","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027927778","display_name":"Graham Land","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"G S Land","raw_affiliation_strings":["Centre for Bio-Pharmaceutical Sciences, Leiden","Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Pharmaceutical Sciences, Leiden","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109127184","display_name":"Douwe D. Breimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"D D Breimer","raw_affiliation_strings":["Centre for Bio-Pharmaceutical Sciences, Leiden","Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Pharmaceutical Sciences, Leiden","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075655236","display_name":"W. C. Yuen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"W C Yuen","raw_affiliation_strings":["Centre for Bio-Pharmaceutical Sciences, Leiden","Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Pharmaceutical Sciences, Leiden","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013976291","display_name":"C Winton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"C Winton","raw_affiliation_strings":["Centre for Bio-Pharmaceutical Sciences, Leiden","Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Pharmaceutical Sciences, Leiden","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113457504","display_name":"Anthony W. Peck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"A W Peck","raw_affiliation_strings":["Centre for Bio-Pharmaceutical Sciences, Leiden","Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Pharmaceutical Sciences, Leiden","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Clinical and Applied Research Division, Wellcome Research Laboratories, Beckenham","institution_ids":["https://openalex.org/I87048295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047227576"],"corresponding_institution_ids":["https://openalex.org/I121797337","https://openalex.org/I87048295"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":3.8737,"has_fulltext":false,"cited_by_count":281,"citation_normalized_percentile":{"value":0.93012704,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"42","issue":"5","first_page":"535","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8529999852180481},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9549999833106995},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.878000020980835},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.968999981880188},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7649999856948853},{"id":"https://openalex.org/keywords/glucuronide-conjugates","display_name":"glucuronide conjugates","score":0.8159999847412109},{"id":"https://openalex.org/keywords/urinary-recovery","display_name":"urinary recovery","score":0.7110000252723694},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.6019999980926514},{"id":"https://openalex.org/keywords/normal-volunteers","display_name":"normal volunteers","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.9023599624633789},{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.8966732025146484},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.7684102058410645},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6952071189880371},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6556446552276611},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5806267857551575},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.5712822675704956},{"id":"https://openalex.org/C2779225474","wikidata":"https://www.wikidata.org/wiki/Q842424","display_name":"Urinalysis","level":3,"score":0.4974382221698761},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.48463162779808044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45910051465034485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37632250785827637},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.37200403213500977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23811030387878418},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.13774198293685913},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077213","descriptor_name":"Lamotrigine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/clpt.1987.193","doi":"https://doi.org/10.1038/clpt.1987.193","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1987.193","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:3677542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3677542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1970278802","https://openalex.org/W2023281672","https://openalex.org/W2038727578","https://openalex.org/W2058739178","https://openalex.org/W2081190121","https://openalex.org/W2119093004","https://openalex.org/W2423092877"],"related_works":["https://openalex.org/W2000630787","https://openalex.org/W1994822561","https://openalex.org/W2555649941","https://openalex.org/W4244955579","https://openalex.org/W2789567641","https://openalex.org/W1986282536","https://openalex.org/W2992186680","https://openalex.org/W2398624152","https://openalex.org/W2357795686","https://openalex.org/W2047200573"],"abstract_inverted_index":{"The":[0,143],"pharmacokinetics":[1,161],"of":[2,24,60,71,73,83,90,97,107,117,176,178],"lamotrigine,":[3],"a":[4,46,112],"new":[5],"anticonvulsant,":[6],"were":[7,81,120,124],"studied":[8],"in":[9,12,187],"three":[10],"studies":[11],"normal":[13],"volunteers.":[14],"In":[15,45,111],"the":[16,56,61,84,98,108,115,152,170,174,201],"first":[17],"study,":[18],"five":[19],"subjects":[20,50,123],"received":[21,51,137],"oral":[22,99],"doses":[23,139],"lamotrigine":[25,54,127],"up":[26],"to":[27,126],"240":[28],"mg.":[29],"A":[30,101],"linear":[31],"relationship":[32],"was":[33,65,95,155],"observed":[34],"between":[35],"dose":[36],"administration":[37,119,164],"and":[38,43,55,70,136],"both":[39],"peak":[40],"drug":[41,91],"concentration":[42],"AUC.":[44],"second":[47],"study":[48,114],"10":[49],"120":[52],"mg":[53],"mean":[57],"(+/-":[58],"SD)":[59],"elimination":[62,146],"half-life":[63],"(t1/2)":[64],"24.1":[66],"+/-":[67,76,157],"5.7":[68],"hours":[69,94],"volume":[72],"distribution/bioavailability":[74],"1.2":[75],"0.12":[77],"L/kg.":[78],"Saliva":[79],"concentrations":[80],"46%":[82],"plasma":[85,145],"concentration.":[86],"Total":[87],"urinary":[88,109],"recovery":[89],"over":[92,140],"144":[93],"70.5%":[96],"dose.":[100],"glucuronide":[102],"conjugate":[103],"accounted":[104],"for":[105],"89.4%":[106],"recovery.":[110],"third":[113],"kinetics":[116],"repeated":[118],"studied.":[121],"Fifteen":[122],"randomized":[125],"(n":[128,133],"=":[129,134],"10)":[130],"or":[131,185,191,197],"placebo":[132],"5)":[135],"multiple":[138,163],"7":[141,153,202],"days.":[142,203],"overall":[144],"t1/2":[147],"calculated":[148],"from":[149,169],"data":[150],"during":[151,200],"days":[154],"25.5":[156],"10.2":[158],"hours.":[159],"Observed":[160],"on":[162],"obeyed":[165],"closely":[166],"those":[167],"predicted":[168],"single-dose":[171],"experiment,":[172],"suggesting":[173],"absence":[175],"autoinduction":[177],"metabolism.":[179],"No":[180],"clinically":[181],"important":[182],"side":[183],"effects":[184],"changes":[186],"central":[188],"nervous":[189],"system":[190,193],"cardiovascular":[192],"variables,":[194],"hematology,":[195],"biochemistry,":[196],"urinalysis":[198],"occurred":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
