{"id":"https://openalex.org/W2010355916","doi":"https://doi.org/10.1016/s0006-8993(99)02004-1","title":"DNA strand breaks in Alzheimer's disease","display_name":"DNA strand breaks in Alzheimer's disease","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2010355916","doi":"https://doi.org/10.1016/s0006-8993(99)02004-1","mag":"2010355916","pmid":"https://pubmed.ncbi.nlm.nih.gov/10592288"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-8993(99)02004-1","doi":"https://doi.org/10.1016/s0006-8993(99)02004-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(99)02004-1","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060743694","display_name":"Emil Adamec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emil Adamec","raw_affiliation_strings":["Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA, USA. eadamec@mercury.mclean.org","Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA, USA. eadamec@mercury.mclean.org","institution_ids":["https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA, USA","institution_ids":["https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113345804","display_name":"Jean Paul Vonsattel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Paul Vonsattel","raw_affiliation_strings":["Laboratory for Molecular Neuropathology, Massachusetts General Hospital, Charlestown, MA 02129, USA","Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Neuropathology, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA","institution_ids":["https://openalex.org/I2801148111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022090615","display_name":"Ralph A. Nixon","orcid":"https://orcid.org/0000-0001-5124-1021","observed_orcids":["https://orcid.org/0000-0001-5124-1021"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph A. Nixon","raw_affiliation_strings":["Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA","institution_ids":["https://openalex.org/I125043107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060743694"],"corresponding_institution_ids":["https://openalex.org/I2801148111"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":2.2069,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.88217145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"849","issue":"1-2","first_page":"67","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.972000002861023},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8119999766349792},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8539999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tunel-assay","display_name":"TUNEL","score":0.8679999709129333},{"id":"https://openalex.org/keywords/single-stranded-dna","display_name":"single-stranded DNA","score":0.8489999771118164},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C54415193","wikidata":"https://www.wikidata.org/wiki/Q424989","display_name":"Klenow fragment","level":5,"score":0.8295180797576904},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6331925392150879},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5811688899993896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5482417345046997},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5239990949630737},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.46331286430358887},{"id":"https://openalex.org/C115960442","wikidata":"https://www.wikidata.org/wiki/Q769863","display_name":"Nuclear DNA","level":4,"score":0.4369232654571533},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4203583598136902},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3200720250606537},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.2622799575328827},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.19905000925064087},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19295290112495422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17783960700035095},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.16344362497329712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09123805165290833},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0689878761768341},{"id":"https://openalex.org/C2777501222","wikidata":"https://www.wikidata.org/wiki/Q411664","display_name":"Exonuclease","level":4,"score":0.05162528157234192},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-8993(99)02004-1","doi":"https://doi.org/10.1016/s0006-8993(99)02004-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(99)02004-1","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:10592288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10592288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1134975624","display_name":null,"funder_award_id":"NS31862","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6772351663","display_name":null,"funder_award_id":"AG000764","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7637191593","display_name":"Massachusetts Alzheimer's Disease Research Center","funder_award_id":"P50AG005134","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W4791965","https://openalex.org/W138616876","https://openalex.org/W168886292","https://openalex.org/W1536213364","https://openalex.org/W1568752613","https://openalex.org/W1613986623","https://openalex.org/W1678726420","https://openalex.org/W1836761553","https://openalex.org/W1907724378","https://openalex.org/W1973541476","https://openalex.org/W1979176029","https://openalex.org/W1981075890","https://openalex.org/W1982990473","https://openalex.org/W1985591678","https://openalex.org/W1987469323","https://openalex.org/W1988147472","https://openalex.org/W1990752558","https://openalex.org/W1993481957","https://openalex.org/W1993767292","https://openalex.org/W1996753093","https://openalex.org/W2002742028","https://openalex.org/W2005624865","https://openalex.org/W2009254352","https://openalex.org/W2011328869","https://openalex.org/W2014388432","https://openalex.org/W2025955916","https://openalex.org/W2026218920","https://openalex.org/W2026903687","https://openalex.org/W2032328804","https://openalex.org/W2034332995","https://openalex.org/W2036065246","https://openalex.org/W2036288989","https://openalex.org/W2043762481","https://openalex.org/W2047649942","https://openalex.org/W2049972682","https://openalex.org/W2053721965","https://openalex.org/W2055541347","https://openalex.org/W2056365448","https://openalex.org/W2056585943","https://openalex.org/W2057638542","https://openalex.org/W2058789249","https://openalex.org/W2067435272","https://openalex.org/W2072092279","https://openalex.org/W2078798112","https://openalex.org/W2082294005","https://openalex.org/W2085271813","https://openalex.org/W2085792129","https://openalex.org/W2087077651","https://openalex.org/W2087781170","https://openalex.org/W2092808670","https://openalex.org/W2093461377","https://openalex.org/W2094141502","https://openalex.org/W2138302361","https://openalex.org/W2148219033","https://openalex.org/W2150825974","https://openalex.org/W2151861142","https://openalex.org/W2166535214","https://openalex.org/W2171257391","https://openalex.org/W2171405125","https://openalex.org/W2215207703","https://openalex.org/W2401309054"],"related_works":["https://openalex.org/W2072092279","https://openalex.org/W3084100386","https://openalex.org/W2947726842","https://openalex.org/W2044616183","https://openalex.org/W4380629936","https://openalex.org/W2158530526","https://openalex.org/W7117274576","https://openalex.org/W2049156839","https://openalex.org/W2171148057","https://openalex.org/W4400684543"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}