{"id":"https://openalex.org/W2010346000","doi":"https://doi.org/10.1111/j.1365-2265.1978.tb02177.x","title":"HYPOTHALAMIC FUNCTION IN MEN WITH HYPOGONADOTROPHIC HYPOGONADISM","display_name":"HYPOTHALAMIC FUNCTION IN MEN WITH HYPOGONADOTROPHIC HYPOGONADISM","publication_year":1978,"publication_date":"1978-05-01","ids":{"openalex":"https://openalex.org/W2010346000","doi":"https://doi.org/10.1111/j.1365-2265.1978.tb02177.x","mag":"2010346000","pmid":"https://pubmed.ncbi.nlm.nih.gov/348348"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2265.1978.tb02177.x","doi":"https://doi.org/10.1111/j.1365-2265.1978.tb02177.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1978.tb02177.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087822746","display_name":"Stephen J. Winters","orcid":"https://orcid.org/0000-0003-3721-7388","observed_orcids":["https://orcid.org/0000-0003-3721-7388"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. J. WINTERS","raw_affiliation_strings":["Developmental Endocrinology Section, Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Endocrinology Section, Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001458737","display_name":"Robert S. Mecklenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. S. MECKLENBURG","raw_affiliation_strings":["Developmental Endocrinology Section, Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Endocrinology Section, Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010225039","display_name":"Richard J. Sherins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. SHERINS","raw_affiliation_strings":["Developmental Endocrinology Section, Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Endocrinology Section, Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087822746"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.3965,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.61793554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":"417","last_page":"426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothalamic-function","display_name":"hypothalamic function","score":0.9190000295639038},{"id":"https://openalex.org/keywords/idiopathic-hypogonadotropic-hypogonadism","display_name":"idiopathic hypogonadotropic hypogonadism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gonadotropin-deficiency","display_name":"gonadotropin deficiency","score":0.8539999723434448},{"id":"https://openalex.org/keywords/water-conservation","display_name":"water conservation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dehydration","display_name":"dehydration","score":0.7649999856948853},{"id":"https://openalex.org/keywords/urine-osmolality","display_name":"urine osmolality","score":0.8870000243186951},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.984000027179718},{"id":"https://openalex.org/keywords/thermoregulation","display_name":"thermoregulation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cold-stress","display_name":"cold stress","score":0.8289999961853027},{"id":"https://openalex.org/keywords/shivering","display_name":"shivering","score":0.9480000138282776},{"id":"https://openalex.org/keywords/core-body-temperature","display_name":"core body temperature","score":0.8619999885559082},{"id":"https://openalex.org/keywords/prolactin-secretion","display_name":"prolactin secretion","score":0.9010000228881836},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.796999990940094},{"id":"https://openalex.org/keywords/pituitary-reserve","display_name":"pituitary reserve","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8842489719390869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8796505928039551},{"id":"https://openalex.org/C2910268463","wikidata":"https://www.wikidata.org/wiki/Q1641332","display_name":"Hypogonadotrophic hypogonadism","level":3,"score":0.8647288084030151},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.8003906607627869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5915570855140686},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.4625624418258667},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.44022059440612793},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.4375634491443634},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4343099296092987},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3871670663356781}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014868","descriptor_name":"Water Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2265.1978.tb02177.x","doi":"https://doi.org/10.1111/j.1365-2265.1978.tb02177.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1978.tb02177.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},{"id":"pmid:348348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/348348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical endocrinology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1985706491","https://openalex.org/W1988609986","https://openalex.org/W1995071066","https://openalex.org/W1995776610","https://openalex.org/W1998411386","https://openalex.org/W2002993270","https://openalex.org/W2021767934","https://openalex.org/W2023844909","https://openalex.org/W2024727717","https://openalex.org/W2027098170","https://openalex.org/W2047374437","https://openalex.org/W2053765178","https://openalex.org/W2055554431","https://openalex.org/W2062890070","https://openalex.org/W2067634959","https://openalex.org/W2069947274","https://openalex.org/W2106290045","https://openalex.org/W2121719285","https://openalex.org/W2125886512","https://openalex.org/W2141712005","https://openalex.org/W2149959392","https://openalex.org/W2168653185","https://openalex.org/W2199082047","https://openalex.org/W2341203038","https://openalex.org/W2467811555"],"related_works":["https://openalex.org/W2077512515","https://openalex.org/W2045243866","https://openalex.org/W2091509392","https://openalex.org/W1972824302","https://openalex.org/W1543633869","https://openalex.org/W2012715726","https://openalex.org/W2077680280","https://openalex.org/W2024727717","https://openalex.org/W1963555022","https://openalex.org/W2007804596"],"abstract_inverted_index":{"To":[0],"determine":[1],"whether":[2],"hypothalamic":[3],"function":[4],"is":[5],"normal":[6,108,129],"in":[7,101,114,161],"patients":[8,69],"with":[9,15,163],"idiopathic":[10,148],"gonadotrophin":[11,136,149],"deficiency,":[12,150],"nine":[13],"men":[14,105,118,162],"this":[16,164],"syndrome":[17],"were":[18,41,89,124],"studied.":[19],"Water":[20],"conservation":[21],"after":[22,64],"overnight":[23],"dehydration,":[24,46],"thermoregulatory":[25],"response":[26,44],"to":[27,45,71],"a":[28,132],"cold":[29,73],"(10":[30],"degrees":[31],"C)":[32],"environmental":[33],"stress":[34],"and":[35,58,78],"prolactin":[36,87],"secretion":[37,134],"following":[38,98],"chlorpromazine":[39],"stimulation":[40],"investigated.":[42],"In":[43],"maximal":[47],"urinary":[48],"osmolality":[49],"was":[50],"1058":[51],"+/-":[52,56,91],"135":[53],"mOsm/kg":[54],"(mean":[55],"SD)":[57],"no":[59],"patient":[60],"showed":[61],"further":[62],"increase":[63],"exogenous":[65],"vasopressin":[66],"administration.":[67],"The":[68],"responded":[70],"the":[72,140,143,155],"stimulus":[74],"by":[75,95,139],"vigorous":[76],"shivering":[77],"maintained":[79],"their":[80],"core":[81],"body":[82],"temperatures.":[83],"Basal":[84],"concentrations":[85,112],"of":[86,103,116,128,135,147],"which":[88],"12.7":[90],"4.6":[92],"ng/ml":[93,97],"increased":[94],"15":[96],"Thyrotrophin-releasing":[99],"hormone":[100,138],"six":[102],"seven":[104,115],"tested,":[106],"indicating":[107],"pituitary":[109],"reserve.":[110],"Prolactin":[111],"doubled":[113],"eight":[117],"who":[119],"received":[120],"chlorpromazine.":[121],"All":[122],"responses":[123],"indistinguishable":[125],"from":[126],"those":[127],"men.":[130],"While":[131],"diminished":[133],"releasing":[137],"hypothalamus":[141],"remains":[142],"most":[144],"plausible":[145],"cause":[146],"our":[151],"data":[152],"indicate":[153],"that":[154],"associated":[156],"functions":[157],"tested":[158],"are":[159],"intact":[160],"syndrome.":[165]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
