{"id":"https://openalex.org/W2010342389","doi":"https://doi.org/10.2337/diab.46.4.717","title":"Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance","display_name":"Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2010342389","doi":"https://doi.org/10.2337/diab.46.4.717","mag":"2010342389","pmid":"https://pubmed.ncbi.nlm.nih.gov/9075817"},"language":"en","primary_location":{"id":"doi:10.2337/diab.46.4.717","doi":"https://doi.org/10.2337/diab.46.4.717","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diab.46.4.717","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/46/4/717/555022/46-4-717.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2010342389"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/46/4/717/555022/46-4-717.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110111987","display_name":"Katerina E. Zakrzewska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"K E Zakrzewska","raw_affiliation_strings":["Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050374215","display_name":"Isabelle Cusin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"I Cusin","raw_affiliation_strings":["Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109958561","display_name":"Amanda Sainsbury","orcid":"https://orcid.org/0000-0001-9176-1574","observed_orcids":["https://orcid.org/0000-0001-9176-1574"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A Sainsbury","raw_affiliation_strings":["Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026690917","display_name":"Fran\u00e7oise Rohner\u2010Jeanrenaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"F Rohner-Jeanrenaud","raw_affiliation_strings":["Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001374323","display_name":"Bernard Jeanrenaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"B Jeanrenaud","raw_affiliation_strings":["Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherches M\u00e9taboliques, Geneva University Medical School\u2008Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114457229"],"apc_list":null,"apc_paid":null,"fwci":8.3138,"has_fulltext":true,"cited_by_count":316,"citation_normalized_percentile":{"value":0.98156389,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"46","issue":"4","first_page":"717","last_page":"719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9860000014305115},{"id":"https://openalex.org/keywords/leptin-resistance","display_name":"leptin resistance","score":0.9850000143051147},{"id":"https://openalex.org/keywords/counterregulatory-hormones","display_name":"counterregulatory hormones","score":0.8600000143051147},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.859000027179718},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.7409999966621399},{"id":"https://openalex.org/keywords/body-weight-regulation","display_name":"body weight regulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hypercortisolism","display_name":"hypercortisolism","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ob-gene","display_name":"ob gene","score":0.5770000219345093},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9523438215255737},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8767573833465576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8718608617782593},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6489863991737366},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.600864827632904},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5219708681106567},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5119718313217163},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.499805212020874},{"id":"https://openalex.org/C2909274461","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Hypophagia","level":3,"score":0.49698498845100403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4505227506160736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3621801733970642}],"mesh":[{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.46.4.717","doi":"https://doi.org/10.2337/diab.46.4.717","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diab.46.4.717","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/46/4/717/555022/46-4-717.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.46.4.717","doi":"https://doi.org/10.2337/diabetes.46.4.717","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.46.4.717","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:9075817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9075817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2337/diab.46.4.717","doi":"https://doi.org/10.2337/diab.46.4.717","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diab.46.4.717","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/46/4/717/555022/46-4-717.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7637644633","display_name":"Neurophysiopathology of obesity/insulin resistance.","funder_award_id":"40806","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010342389.pdf","grobid_xml":"https://content.openalex.org/works/W2010342389.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1778048023","https://openalex.org/W1939837952","https://openalex.org/W1954333522","https://openalex.org/W1993021677","https://openalex.org/W2013583119","https://openalex.org/W2033305745","https://openalex.org/W2051559850","https://openalex.org/W2064243592","https://openalex.org/W2067020358","https://openalex.org/W2075019242","https://openalex.org/W2086496276","https://openalex.org/W2088072110","https://openalex.org/W2095396162","https://openalex.org/W2114010003","https://openalex.org/W2154555913","https://openalex.org/W2220992488","https://openalex.org/W2258649170","https://openalex.org/W2298290831","https://openalex.org/W2300209542","https://openalex.org/W2342025204","https://openalex.org/W4251240516"],"related_works":["https://openalex.org/W2106417494","https://openalex.org/W1994514157","https://openalex.org/W2050930379","https://openalex.org/W2073107167","https://openalex.org/W48554332","https://openalex.org/W2127375867","https://openalex.org/W2161187682","https://openalex.org/W2084068133","https://openalex.org/W7097411156"],"abstract_inverted_index":{"The":[0],"product":[1],"of":[2,23,59,75,83,104,128,136,151,159,169],"the":[3,17,21,24,55,73,101,149],"ob":[4],"gene,":[5],"leptin,":[6],"is":[7,179],"a":[8,51,81,144],"hormone":[9],"secreted":[10],"by":[11,71],"adipose":[12],"tissue":[13],"that":[14,67,141],"acts":[15],"in":[16,54,62,86,92,112,148],"hypothalamus":[18],"to":[19,34,49,122,174],"regulate":[20],"size":[22],"body":[25,39,93,115],"fat":[26],"depot.":[27],"Its":[28],"central":[29],"administration":[30],"has":[31],"been":[32],"shown":[33],"decrease":[35],"food":[36,96,118],"intake":[37,119],"and":[38,57,95,109,117],"weight,":[40],"while":[41],"favoring":[42],"energy":[43],"dissipation.":[44],"As":[45],"glucocorticoids":[46,142,160],"are":[47],"known":[48],"play":[50,143],"permissive":[52],"role":[53,147],"establishment":[56],"maintenance":[58],"obesity":[60,166],"syndromes":[61],"rodents,":[63],"it":[64,171],"was":[65],"hypothesized":[66],"they":[68],"do":[69],"so":[70],"restraining":[72],"effect":[74],"leptin.":[76,137,152],"Leptin":[77],"injected":[78],"intracerebroventricularly":[79],"as":[80],"bolus":[82],"3":[84],"microg":[85],"normal":[87,154],"rats":[88,130],"induced":[89],"modest":[90],"reductions":[91],"weight":[94,116],"intake.":[97],"In":[98,165],"marked":[99],"contrast,":[100],"same":[102],"dose":[103],"leptin":[105],"had":[106],"very":[107],"potent":[108,134],"long-lasting":[110],"effects":[111,135],"decreasing":[113],"both":[114],"when":[120],"administered":[121],"adrenalectomized":[123,129],"rats.":[124],"Further,":[125],"glucocorticoid":[126],"supplementation":[127],"dose-dependently":[131],"inhibited":[132],"these":[133],"These":[138],"data":[139],"suggest":[140],"key":[145],"inhibitory":[146,157],"action":[150],"Under":[153],"conditions,":[155],"this":[156],"influence":[158],"may":[161,172],"prevent":[162],"lasting":[163],"hypophagia.":[164],"with":[167],"degrees":[168],"hypercorticism,":[170],"contribute":[173],"\"leptin":[175],"resistance,\"":[176],"whose":[177],"etiology":[178],"still":[180],"little":[181],"understood.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}