{"id":"https://openalex.org/W2010340952","doi":"https://doi.org/10.1002/ijc.1205","title":"Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma","display_name":"Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2010340952","doi":"https://doi.org/10.1002/ijc.1205","mag":"2010340952","pmid":"https://pubmed.ncbi.nlm.nih.gov/11291084"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.1205","doi":"https://doi.org/10.1002/ijc.1205","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.1205","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.1205","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.1205","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046501213","display_name":"Marianne Klemp","orcid":"https://orcid.org/0000-0002-9530-8344","observed_orcids":["https://orcid.org/0000-0002-9530-8344"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Marianne K. Gjertsen","raw_affiliation_strings":["Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway. m.k.gjertsen@labmed.uio.no","Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway. m.k.gjertsen@labmed.uio.no","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014470340","display_name":"Trond A Buanes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Trond Buanes","raw_affiliation_strings":["Department of Surgery, Ulleva\u030al Hospital, University of Oslo, Oslo, Norway","Department of Surgery, Ullev\u00e5l Hospital, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Ulleva\u030al Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Department of Surgery, Ullev\u00e5l Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084792733","display_name":"Arne R. Rosseland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arne R. Rosseland","raw_affiliation_strings":["Department of Surgery, Central Hospital of Akershus, Nordbyhagen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Central Hospital of Akershus, Nordbyhagen, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069297948","display_name":"Arne Olav Bakka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Arne Bakka","raw_affiliation_strings":["Surgical Department B, National Hospital, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Department B, National Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110475513","display_name":"Ivar P. Gladhaug","orcid":"https://orcid.org/0000-0003-1441-6288","observed_orcids":["https://orcid.org/0000-0003-1441-6288"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ivar Gladhaug","raw_affiliation_strings":["Surgical Department B, National Hospital, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Department B, National Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061527128","display_name":"Odd S\ufffdreide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Odd S\ufffdreide","raw_affiliation_strings":["Surgical Department B, National Hospital, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Department B, National Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103447662","display_name":"Jon Amund Eriksen","orcid":"https://orcid.org/0009-0007-9987-6764","observed_orcids":["https://orcid.org/0009-0007-9987-6764"]},"institutions":[{"id":"https://openalex.org/I4210132748","display_name":"Norsk Hydro (Norway)","ror":"https://ror.org/03vx93323","country_code":"NO","type":"company","lineage":["https://openalex.org/I4210132748"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Jon A. Eriksen","raw_affiliation_strings":["Norsk Hydro Research Center, Porsgrunn, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norsk Hydro Research Center, Porsgrunn, Norway","institution_ids":["https://openalex.org/I4210132748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113568233","display_name":"Mona M\ufffdller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132748","display_name":"Norsk Hydro (Norway)","ror":"https://ror.org/03vx93323","country_code":"NO","type":"company","lineage":["https://openalex.org/I4210132748"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Mona M\ufffdller","raw_affiliation_strings":["Norsk Hydro Research Center, Porsgrunn, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norsk Hydro Research Center, Porsgrunn, Norway","institution_ids":["https://openalex.org/I4210132748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110013845","display_name":"Ingebj\ufffdrg Baksaas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingebj\ufffdrg Baksaas","raw_affiliation_strings":["Mericon, Skien, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mericon, Skien, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089685702","display_name":"Ragnhild A. Lothe","orcid":"https://orcid.org/0000-0002-1693-1032","observed_orcids":["https://orcid.org/0000-0002-1693-1032"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ragnhild A. Lothe","raw_affiliation_strings":["Department of Genetics, Norwegian Radium Hospital, University of Oslo, Oslo, Norway","Department of Pathology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Norwegian Radium Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Department of Pathology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097962221","display_name":"Ingvil S\ufffdterdal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ingvil S\ufffdterdal","raw_affiliation_strings":["Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003293427","display_name":"Gustav Gaudernack","orcid":"https://orcid.org/0000-0002-9678-7447","observed_orcids":["https://orcid.org/0000-0002-9678-7447"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Gustav Gaudernack","raw_affiliation_strings":["Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046501213"],"corresponding_institution_ids":["https://openalex.org/I184942183"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":5.0193,"has_fulltext":true,"cited_by_count":278,"citation_normalized_percentile":{"value":0.96192334,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"92","issue":"3","first_page":"441","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.16979999840259552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/intradermal-vaccination","display_name":"intradermal vaccination","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9240000247955322},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tumor-specific-t-cells","display_name":"tumor-specific T cells","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.7720000147819519},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5080000162124634},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7017108201980591},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6397901177406311},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5641142129898071},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5639139413833618},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5385962128639221},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5152164101600647},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4947916865348816},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.45829376578330994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43223050236701965},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4051131308078766},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3459452688694}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.1205","doi":"https://doi.org/10.1002/ijc.1205","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.1205","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.1205","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:11291084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11291084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/ijc.1205","doi":"https://doi.org/10.1002/ijc.1205","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.1205","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.1205","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010340952.pdf","grobid_xml":"https://content.openalex.org/works/W2010340952.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W181590604","https://openalex.org/W1966639728","https://openalex.org/W1983739608","https://openalex.org/W1983806918","https://openalex.org/W1983954483","https://openalex.org/W2025502201","https://openalex.org/W2026462941","https://openalex.org/W2028767282","https://openalex.org/W2030334592","https://openalex.org/W2036272741","https://openalex.org/W2041601304","https://openalex.org/W2049364599","https://openalex.org/W2053976077","https://openalex.org/W2058530324","https://openalex.org/W2066964346","https://openalex.org/W2068595510","https://openalex.org/W2075531452","https://openalex.org/W2086704878","https://openalex.org/W2092815945","https://openalex.org/W2107291841","https://openalex.org/W2125042952","https://openalex.org/W2129636093","https://openalex.org/W2131761283","https://openalex.org/W2164034599","https://openalex.org/W2164486810","https://openalex.org/W2177327503","https://openalex.org/W2263690628","https://openalex.org/W3134530972","https://openalex.org/W4231031590"],"related_works":["https://openalex.org/W2534357065","https://openalex.org/W2020259979","https://openalex.org/W2248413236","https://openalex.org/W2092815945","https://openalex.org/W2036505398","https://openalex.org/W2107291841","https://openalex.org/W2055624681","https://openalex.org/W2049075105","https://openalex.org/W2169701723","https://openalex.org/W2763541973"],"abstract_inverted_index":{"K-RAS":[0],"mutations":[1],"are":[2],"frequently":[3],"found":[4],"in":[5,24,54,80,102,134,155,162,207],"adenocarcinomas":[6],"of":[7,12,20,42,49,82,97,114,116,183,203,227,237],"the":[8,43,89,121,135,156,174,181,210,220],"pancreas,":[9],"and":[10,65,95,215],"induction":[11,115],"immunity":[13,77],"against":[14,120,219],"mutant":[15,51],"ras":[16,52,122,228],"can":[17],"therefore":[18],"be":[19,138,232],"possible":[21],"clinical":[22,34,225],"benefit":[23,226],"patients":[25,39,61,103,204],"with":[26,40,56,67,104,128,166],"pancreatic":[27],"cancer.":[28],"We":[29],"present":[30,133],"data":[31],"from":[32,140,180],"a":[33,141,200,224],"phase":[35],"I/II":[36],"trial":[37],"involving":[38],"adenocarcinoma":[41],"pancreas":[44],"vaccinated":[45],"by":[46],"i.d.":[47],"injection":[48],"synthetic":[50],"peptides":[53],"combination":[55],"granulocyte-macrophage":[57],"colony-stimulating":[58],"factor.":[59],"Forty-eight":[60],"(10":[62],"surgically":[63],"resected":[64],"38":[66],"advanced":[68,167],"disease)":[69],"were":[70,150,205],"treated":[71],"on":[72],"an":[73,129,170,216],"outpatient":[74],"basis.":[75],"Peptide-specific":[76],"was":[78,159],"induced":[79],"25":[81],"43":[83],"(58%)":[84],"evaluable":[85],"patients,":[86],"indicating":[87],"that":[88,145,223],"protocol":[90],"used":[91],"is":[92],"very":[93],"potent":[94],"capable":[96],"eliciting":[98],"immune":[99,171,217],"responses":[100],"even":[101],"end-stage":[105],"disease.":[106],"Patients":[107,165],"followed-up":[108],"for":[109,234],"longer":[110],"periods":[111],"showed":[112,177],"evidence":[113],"long-lived":[117],"immunological":[118],"memory":[119],"mutations.":[123],"CD4(+)":[124],"T":[125,148],"cells":[126,149],"reactive":[127],"Arg12":[130],"mutation":[131],"also":[132],"tumor":[136,142],"could":[137],"isolated":[139],"biopsy,":[143],"demonstrating":[144,169],"activated,":[146],"ras-specific":[147],"able":[151],"to":[152,173,186],"selectively":[153],"accumulate":[154],"tumor.":[157],"Vaccination":[158],"well":[160],"tolerated":[161],"all":[163],"patients.":[164,238],"cancer":[168],"response":[172,218],"peptide":[175,229],"vaccine":[176,221],"prolonged":[178,213],"survival":[179,189,214],"start":[182],"treatment":[184],"compared":[185],"non-responders":[187],"(median":[188],"148":[190],"days":[191],"vs.":[192],"61":[193],"days,":[194],"respectively;":[195],"p":[196],"=":[197],"0.0002).":[198],"Although":[199],"limited":[201],"number":[202],"included":[206],"our":[208],"study,":[209],"association":[211],"between":[212],"suggests":[222],"vaccination":[230],"may":[231],"obtained":[233],"this":[235],"group":[236]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}