{"id":"https://openalex.org/W2010328277","doi":"https://doi.org/10.1074/jbc.m208358200","title":"The Class A Scavenger Receptor Binds to Proteoglycans and Mediates Adhesion of Macrophages to the Extracellular Matrix","display_name":"The Class A Scavenger Receptor Binds to Proteoglycans and Mediates Adhesion of Macrophages to the Extracellular Matrix","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2010328277","doi":"https://doi.org/10.1074/jbc.m208358200","mag":"2010328277","pmid":"https://pubmed.ncbi.nlm.nih.gov/12488451"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m208358200","doi":"https://doi.org/10.1074/jbc.m208358200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m208358200","pdf_url":"http://www.jbc.org/article/S0021925819326201/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819326201/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074929764","display_name":"Juan Santiago-Garc\u00eda","orcid":"https://orcid.org/0000-0003-1737-0270","observed_orcids":["https://orcid.org/0000-0003-1737-0270"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Santiago-Garc\u0131\u0301a","raw_affiliation_strings":["Cardiovascular Research Institute,","Gladstone Institutes of Cardiovascular Disease and Neurological Disease,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute,","institution_ids":[]},{"raw_affiliation_string":"Gladstone Institutes of Cardiovascular Disease and Neurological Disease,","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107007603","display_name":"Tatsuhiko Kodama","orcid":"https://orcid.org/0000-0003-3747-7956","observed_orcids":["https://orcid.org/0000-0003-3747-7956"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuhiko Kodama","raw_affiliation_strings":["Department of Molecular Biology and Medicine, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Medicine, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063890834","display_name":"Robert E. Pitas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert E. Pitas","raw_affiliation_strings":["Cardiovascular Research Institute,","Department of Pathology, University of California, San Francisco, California 94143","Gladstone Institutes of Cardiovascular Disease and Neurological Disease,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute,","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Institutes of Cardiovascular Disease and Neurological Disease,","institution_ids":["https://openalex.org/I1321430492"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063890834"],"corresponding_institution_ids":["https://openalex.org/I1321430492","https://openalex.org/I180670191"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5104,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.78930249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"278","issue":"9","first_page":"6942","last_page":"6946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.22349999845027924,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scavenger-receptor-a","display_name":"scavenger receptor A","score":0.9570000171661377},{"id":"https://openalex.org/keywords/macrophage-adhesion","display_name":"macrophage adhesion","score":0.9490000009536743},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9819999933242798},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.9610000252723694},{"id":"https://openalex.org/keywords/biglycan","display_name":"biglycan","score":0.875},{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":1.0},{"id":"https://openalex.org/keywords/fucoidan","display_name":"fucoidan","score":0.8299999833106995},{"id":"https://openalex.org/keywords/divalent-cations","display_name":"divalent cations","score":0.7739999890327454},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.699999988079071},{"id":"https://openalex.org/keywords/modified-lipoproteins","display_name":"modified lipoproteins","score":0.7839999794960022},{"id":"https://openalex.org/keywords/acetylated-ldl","display_name":"acetylated LDL","score":0.847000002861023},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.775302529335022},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7219340801239014},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6748459339141846},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.6229618787765503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5297570824623108},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45927032828330994},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.45610693097114563},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.44324713945388794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26014965772628784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2077728807926178},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058575","descriptor_name":"Decorin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058578","descriptor_name":"Biglycan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m208358200","doi":"https://doi.org/10.1074/jbc.m208358200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m208358200","pdf_url":"http://www.jbc.org/article/S0021925819326201/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12488451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12488451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m208358200","doi":"https://doi.org/10.1074/jbc.m208358200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m208358200","pdf_url":"http://www.jbc.org/article/S0021925819326201/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320308294","display_name":"Tobacco-Related Disease Research Program","ror":"https://ror.org/00pjdza24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010328277.pdf","grobid_xml":"https://content.openalex.org/works/W2010328277.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W334182892","https://openalex.org/W563924022","https://openalex.org/W941423621","https://openalex.org/W1270005002","https://openalex.org/W1522459970","https://openalex.org/W1585416598","https://openalex.org/W1586297781","https://openalex.org/W1653408396","https://openalex.org/W1923107093","https://openalex.org/W1966244957","https://openalex.org/W1967237003","https://openalex.org/W1980422185","https://openalex.org/W1992461465","https://openalex.org/W1993002482","https://openalex.org/W1995510456","https://openalex.org/W2019405824","https://openalex.org/W2030256169","https://openalex.org/W2032731208","https://openalex.org/W2033382511","https://openalex.org/W2037599912","https://openalex.org/W2038484123","https://openalex.org/W2041016354","https://openalex.org/W2043229624","https://openalex.org/W2045560271","https://openalex.org/W2048435568","https://openalex.org/W2049401036","https://openalex.org/W2054556903","https://openalex.org/W2080697639","https://openalex.org/W2086278983","https://openalex.org/W2087797124","https://openalex.org/W2092411904","https://openalex.org/W2093782393","https://openalex.org/W2094901737","https://openalex.org/W2096096506","https://openalex.org/W2107611361","https://openalex.org/W2120347833","https://openalex.org/W2120626817","https://openalex.org/W2154069175","https://openalex.org/W2154458451","https://openalex.org/W2158789950","https://openalex.org/W2396983081","https://openalex.org/W2412907297"],"related_works":["https://openalex.org/W1995510456","https://openalex.org/W2050714537","https://openalex.org/W2130239011","https://openalex.org/W169311468","https://openalex.org/W6999930728","https://openalex.org/W2043195237","https://openalex.org/W2075879675","https://openalex.org/W2367107939","https://openalex.org/W2099830109","https://openalex.org/W3171181856"],"abstract_inverted_index":{"The":[0,19,54],"class":[1],"A":[2],"scavenger":[3],"receptor":[4],"(SR-A)":[5],"binds":[6],"modified":[7],"lipoproteins":[8],"and":[9,28,41,58,70,87,94,112,137,143,147,163,165,167,175],"has":[10],"been":[11],"implicated":[12],"in":[13,17,67],"cholesterol":[14],"ester":[15],"deposition":[16],"macrophages.":[18],"SR-A":[20,34,55,84,109,122,134,193],"also":[21],"contributes":[22],"to":[23,46,63,79,100,196,201],"cellular":[24],"adhesion.":[25],"Using":[26],"SR-A(+/+)":[27],"SR-A(-)/-":[29],"murine":[30],"macrophages,":[31],"we":[32],"found":[33],"expression":[35],"important":[36],"for":[37,158,170,185],"both":[38],"divalent":[39,81],"cation-dependent":[40],"-independent":[42],"adhesion":[43,62,92,99,198],"of":[44,60,72,89,115,145,160,177,199,205],"macrophages":[45,200],"the":[47,64,68,83,90,101,116,133,171,186,192,197,202],"human":[48],"smooth":[49],"muscle":[50],"cell":[51,140,173],"extracellular":[52,65,102,117,203],"matrix.":[53],"mediated":[56,85],"65":[57],"85%":[59],"macrophage":[61,91],"matrix":[66,103,204],"presence":[69],"absence":[71],"serum,":[73,96],"respectively.":[74,97,149],"When":[75],"EDTA":[76],"was":[77,104],"added":[78],"chelate":[80],"cations,":[82],"90":[86],"95%":[88],"without":[93],"with":[95,125],"SR-A-mediated":[98,172],"prevented":[105],"by":[106],"fucoidin,":[107],"an":[108],"antagonist.":[110],"Biglycan":[111],"decorin,":[113],"proteoglycans":[114],"matrix,":[118],"were":[119],"identified":[120],"as":[121],"ligands.":[123],"Compared":[124],"control":[126],"cells,":[127],"Chinese":[128],"hamster":[129],"ovary":[130],"cells":[131],"expressing":[132],"showed":[135],"5-":[136],"6-fold":[138],"greater":[139],"association":[141,174],"(binding":[142],"internalization)":[144],"(125)I-decorin":[146],"-biglycan,":[148,164],"In":[150],"competition":[151],"studies,":[152],"unlabeled":[153],"proteoglycan":[154],"or":[155],"fucoidin":[156],"competed":[157,169],"binding":[159],"(125)I-labeled":[161,178],"decorin":[162,168],"biglycan":[166],"degradation":[176],"acetylated":[179],"LDL,":[180],"a":[181],"well":[182],"characterized":[183],"ligand":[184],"SR-A.":[187],"These":[188],"results":[189],"suggest":[190],"that":[191],"could":[194],"contribute":[195],"atherosclerotic":[206],"plaques.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
