{"id":"https://openalex.org/W2010314974","doi":"https://doi.org/10.1097/lgt.0b013e31806dba20","title":"Why Do Human Papillomavirus Infections Induce Sharply Demarcated Lesions of the Cervix?","display_name":"Why Do Human Papillomavirus Infections Induce Sharply Demarcated Lesions of the Cervix?","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2010314974","doi":"https://doi.org/10.1097/lgt.0b013e31806dba20","mag":"2010314974","pmid":"https://pubmed.ncbi.nlm.nih.gov/18162805"},"language":"en","primary_location":{"id":"doi:10.1097/lgt.0b013e31806dba20","doi":"https://doi.org/10.1097/lgt.0b013e31806dba20","is_oa":false,"landing_page_url":"https://doi.org/10.1097/lgt.0b013e31806dba20","pdf_url":null,"source":{"id":"https://openalex.org/S6499114","display_name":"Journal of Lower Genital Tract Disease","issn_l":"1089-2591","issn":["1089-2591","1526-0976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lower Genital Tract Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085478795","display_name":"Olaf Reich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]},{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Olaf Reich","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Medical University Graz, Austria. olaf.reich@meduni-graz.at","Department of Obstetrics and Gynecology and","Olaf Reich, MD, Department of Obstetrics and Gynecology, Medical University Graz, Auenbruggerplatz 14, A-8036 Graz, Austria. E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Medical University Graz, Austria. olaf.reich@meduni-graz.at","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology and","institution_ids":[]},{"raw_affiliation_string":"Olaf Reich, MD, Department of Obstetrics and Gynecology, Medical University Graz, Auenbruggerplatz 14, A-8036 Graz, Austria. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I15766117","https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111646295","display_name":"Hellmuth Pickel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hellmuth Pickel","raw_affiliation_strings":["Department of Obstetrics and Gynecology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006736868","display_name":"Sigrid Regauer","orcid":"https://orcid.org/0000-0002-7077-578X","observed_orcids":["https://orcid.org/0000-0002-7077-578X"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sigrid Regauer","raw_affiliation_strings":["Institute of Pathology, Medical University Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Medical University Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085478795"],"corresponding_institution_ids":["https://openalex.org/I15766117","https://openalex.org/I202276237"],"apc_list":null,"apc_paid":null,"fwci":0.6502,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.69970909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"8","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cervical-intraepithelial-neoplasia","display_name":"cervical intraepithelial neoplasia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hpv-induced-carcinogenesis","display_name":"HPV-induced carcinogenesis","score":0.5699999928474426},{"id":"https://openalex.org/keywords/squamous-metaplasia","display_name":"squamous metaplasia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/colposcopic-findings","display_name":"colposcopic findings","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hpv-genotypes","display_name":"HPV genotypes","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cervical-carcinogenesis","display_name":"cervical carcinogenesis","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7498067617416382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7107165455818176},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6765643954277039},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.6607683897018433},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6044996976852417},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.5681350231170654},{"id":"https://openalex.org/C138055712","wikidata":"https://www.wikidata.org/wiki/Q924466","display_name":"Koilocyte","level":5,"score":0.5123544931411743},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48253247141838074},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.462103009223938},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.42014601826667786},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.4120185375213623},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36413341760635376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1621561348438263},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/lgt.0b013e31806dba20","doi":"https://doi.org/10.1097/lgt.0b013e31806dba20","is_oa":false,"landing_page_url":"https://doi.org/10.1097/lgt.0b013e31806dba20","pdf_url":null,"source":{"id":"https://openalex.org/S6499114","display_name":"Journal of Lower Genital Tract Disease","issn_l":"1089-2591","issn":["1089-2591","1526-0976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lower Genital Tract Disease","raw_type":"journal-article"},{"id":"pmid:18162805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18162805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lower genital tract disease","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323313","display_name":"Turun Yliopisto","ror":"https://ror.org/05vghhr25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1972455627","https://openalex.org/W1999018641","https://openalex.org/W2010512766","https://openalex.org/W2087050584","https://openalex.org/W2130859532","https://openalex.org/W2400381509"],"related_works":["https://openalex.org/W2979000886","https://openalex.org/W2402884719","https://openalex.org/W4206889698","https://openalex.org/W2033079637","https://openalex.org/W2415690987","https://openalex.org/W2158344731","https://openalex.org/W7217691594","https://openalex.org/W6931623652","https://openalex.org/W2744141511","https://openalex.org/W3137802623"],"abstract_inverted_index":{"In":[0,129],"Brief":[1],"Chronic":[2],"infections":[3],"with":[4,167],"high-risk":[5,168],"human":[6,169],"papilloma":[7],"virus":[8],"(HPV)":[9,171],"have":[10,172],"been":[11,46,173],"established":[12,175],"to":[13,25,48],"cause":[14],"cervical":[15,21,60,64,88,130,180,186,203],"cancer.":[16],"The":[17,100,197],"causal":[18,145,200],"pathogenesis":[19,136,146,178],"of":[20,29,32,106,118,147,164,179,185],"carcinoma":[22],"is":[23,151,194,205],"believed":[24],"be":[26,93],"the":[27,30,82,104,115,132,144,161,177,182],"result":[28],"proliferation":[31],"one":[33],"or,":[34],"at":[35],"most,":[36],"a":[37],"few":[38],"HPV-transformed":[39],"cells.":[40],"So":[41],"far,":[42],"it":[43,193],"has":[44],"not":[45,195],"possible":[47],"identify":[49],"and":[50,91,114,140,143,154,201],"analyze":[51],"these":[52],"early":[53],"initial":[54],"lesions":[55],"or":[56,120],"cell":[57],"clusters.":[58],"Invasive":[59],"cancer":[61],"arises":[62],"in":[63,68,72,75,87,110,176,189],"intraepithelial":[65,89,112,187],"neoplasia,":[66],"which":[67],"turn":[69],"develops":[70],"preferentially":[71],"squamous":[73],"metaplasia":[74],"clearly":[76],"demarcated":[77],"fields.":[78],"These":[79],"fields":[80,109,192],"are":[81],"main":[83],"salient":[84],"morphologic":[85,183],"characteristic":[86],"neoplasia":[90,113,188],"can":[92],"recognized":[94],"colposcopically":[95],"as":[96,98,138],"well":[97,174],"histomorphologically.":[99],"precise":[101],"mechanism":[102],"for":[103,123,157],"development":[105],"separate,":[107],"well-delineated":[108],"HPV-related":[111],"variable":[116],"susceptibility":[117],"stem":[119],"reserve":[121],"cells":[122],"different":[124],"HPV":[125],"genotypes":[126],"remains":[127],"unsolved.":[128],"carcinogenesis,":[131],"link":[133,198],"between":[134,199],"formal":[135,202],"apparent":[137],"colposcopic":[139],"histomorphologic":[141],"changes":[142,150],"HPV-induced":[148],"genetic":[149],"still":[152,206],"missing":[153],"an":[155],"issue":[156],"future":[158],"research.":[159],"Although":[160],"molecular":[162],"mechanisms":[163],"chronic":[165],"infection":[166],"papillomavirus":[170],"cancer,":[181],"finding":[184],"sharply":[190],"defined":[191],"understood.":[196],"carcinogenesis":[204],"missing.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}