{"id":"https://openalex.org/W2010297786","doi":"https://doi.org/10.1358/dnp.2010.23.10.1560143","title":"Epigenetic alterations of tumor marker microRNAs: Towards new cancer therapies","display_name":"Epigenetic alterations of tumor marker microRNAs: Towards new cancer therapies","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2010297786","doi":"https://doi.org/10.1358/dnp.2010.23.10.1560143","mag":"2010297786","pmid":"https://pubmed.ncbi.nlm.nih.gov/21180651"},"language":"en","primary_location":{"id":"doi:10.1358/dnp.2010.23.10.1560143","doi":"https://doi.org/10.1358/dnp.2010.23.10.1560143","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dnp.2010.23.10.1560143","pdf_url":null,"source":{"id":"https://openalex.org/S51538572","display_name":"Drug News & Perspectives","issn_l":"0214-0934","issn":["0214-0934","2013-0139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug News & Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045723123","display_name":"Jia Wei","orcid":"https://orcid.org/0000-0003-3024-8878","observed_orcids":["https://orcid.org/0000-0003-3024-8878","https://orcid.org/0000-0002-6792-4959"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei, J.","raw_affiliation_strings":["Department of Oncology, Affiliated Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. weijia01627@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Affiliated Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China. weijia01627@hotmail.com","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086284926","display_name":"Li Xie","orcid":"https://orcid.org/0000-0003-3397-2407","observed_orcids":["https://orcid.org/0000-0003-3397-2407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xie, L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030827550","display_name":"Miquel Tar\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taron, M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110914602","display_name":"Rafael Rosell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosell, R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004716187","display_name":"Baorui Liu","orcid":"https://orcid.org/0000-0002-2539-7732","observed_orcids":["https://orcid.org/0000-0002-2539-7732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, B.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4025,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.62796443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"23","issue":"10","first_page":"655","last_page":"655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9869999885559082},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.847000002861023},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.6209999918937683},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.9221000671386719},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7977598309516907},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5645561814308167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.558607280254364},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5517992377281189},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5057189464569092},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4691328704357147},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.44771260023117065},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4346630573272705},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42872220277786255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4153825640678406},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38679784536361694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22450807690620422}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1358/dnp.2010.23.10.1560143","doi":"https://doi.org/10.1358/dnp.2010.23.10.1560143","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dnp.2010.23.10.1560143","pdf_url":null,"source":{"id":"https://openalex.org/S51538572","display_name":"Drug News & Perspectives","issn_l":"0214-0934","issn":["0214-0934","2013-0139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug News & Perspectives","raw_type":"journal-article"},{"id":"pmid:21180651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21180651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug news & perspectives","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7200000286102295,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971466042","https://openalex.org/W3182143999","https://openalex.org/W2040350615","https://openalex.org/W2020656583","https://openalex.org/W2083605403","https://openalex.org/W3092357984","https://openalex.org/W2164642866","https://openalex.org/W2136853577","https://openalex.org/W3048404543","https://openalex.org/W1966402618"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2],"a":[3,54,71],"class":[4],"of":[5,15,23,41,46,68,84],"short":[6],"noncoding":[7],"RNAs":[8],"that":[9,50],"participate":[10],"in":[11,57,76,93],"mastering":[12],"the":[13,82,89],"balance":[14],"gene-regulating":[16],"networks.":[17],"By":[18],"targeting":[19],"and":[20,34,60],"controlling":[21],"expression":[22,40],"messenger":[24],"RNA,":[25],"miRNAs":[26],"can":[27],"control":[28],"highly":[29],"complex":[30],"signal":[31],"transduction":[32],"pathways":[33],"other":[35],"biological":[36],"pathways.":[37],"Unique":[38],"aberrant":[39],"miRNA":[42,51,69,75],"at":[43],"each":[44],"stage":[45],"cancer":[47,58,77,94],"development":[48],"suggests":[49,70],"could":[52],"play":[53],"novel":[55],"role":[56],"diagnosis":[59],"therapeutic":[61],"strategies.":[62],"Accumulated":[63],"information":[64],"on":[65],"epigenetic":[66],"modification":[67],"promising":[72],"platform":[73],"for":[74],"therapy.":[78],"Clinical":[79],"applications":[80],"exploiting":[81],"understanding":[83],"miRNA's":[85],"function":[86],"will":[87],"be":[88],"next":[90],"great":[91],"challenge":[92],"research.":[95]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}