{"id":"https://openalex.org/W2010283540","doi":"https://doi.org/10.1016/0014-4835(76)90200-1","title":"Aryl hydrocarbon hydroxylase induction in retinal pigmented epithelium: Possible association of genetic differences in a drug-metabolizing enzyme system with retinal degeneration","display_name":"Aryl hydrocarbon hydroxylase induction in retinal pigmented epithelium: Possible association of genetic differences in a drug-metabolizing enzyme system with retinal degeneration","publication_year":1976,"publication_date":"1976-08-01","ids":{"openalex":"https://openalex.org/W2010283540","doi":"https://doi.org/10.1016/0014-4835(76)90200-1","mag":"2010283540","pmid":"https://pubmed.ncbi.nlm.nih.gov/976366"},"language":"en","primary_location":{"id":"doi:10.1016/0014-4835(76)90200-1","doi":"https://doi.org/10.1016/0014-4835(76)90200-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-4835(76)90200-1","pdf_url":null,"source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002507714","display_name":"Hitoshi Shichi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hitoshi Shichi","raw_affiliation_strings":["Laboratory of Vision Research, National Eye Institute, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Md 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vision Research, National Eye Institute, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Md 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038938929","display_name":"Yasuhiko Tsunematsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasuhiko Tsunematsu","raw_affiliation_strings":["Laboratory of Vision Research, National Eye Institute, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Md 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vision Research, National Eye Institute, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Md 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029237881","display_name":"Daniel W. Nebert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel W. Nebert","raw_affiliation_strings":["Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Md 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health, Education and Welfare, Bethesda, Md 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002507714"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":null,"fwci":0.7881,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.71135135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"23","issue":"2","first_page":"165","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.18160000443458557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-hydroxylase","display_name":"aryl hydrocarbon hydroxylase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8830000162124634},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.8809999823570251},{"id":"https://openalex.org/keywords/beta-naphthoflavone","display_name":"beta-naphthoflavone","score":0.8339999914169312},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6039999723434448},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.7549999952316284},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8550000190734863},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.7839999794960022},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.7509999871253967},{"id":"https://openalex.org/keywords/lysosomal-membrane-damage","display_name":"lysosomal membrane damage","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.5489611029624939},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5138121247291565},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.512761652469635},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.5005695819854736},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.45078858733177185},{"id":"https://openalex.org/C76725341","wikidata":"https://www.wikidata.org/wiki/Q1893126","display_name":"Inbred strain","level":3,"score":0.44765010476112366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39606544375419617},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34863734245300293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11964830756187439},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001189","descriptor_name":"Aryl Hydrocarbon Hydroxylases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001551","descriptor_name":"Benz(a)Anthracenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001579","descriptor_name":"Benzopyrene Hydroxylase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-4835(76)90200-1","doi":"https://doi.org/10.1016/0014-4835(76)90200-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-4835(76)90200-1","pdf_url":null,"source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},{"id":"pmid:976366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/976366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental eye research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W29653919","https://openalex.org/W58511869","https://openalex.org/W169036099","https://openalex.org/W172739833","https://openalex.org/W1229641526","https://openalex.org/W1511019684","https://openalex.org/W1538270730","https://openalex.org/W1575532099","https://openalex.org/W1580479508","https://openalex.org/W1715091863","https://openalex.org/W1775749144","https://openalex.org/W1875291053","https://openalex.org/W1940747546","https://openalex.org/W1982137790","https://openalex.org/W1982386536","https://openalex.org/W1984713897","https://openalex.org/W2001488073","https://openalex.org/W2002301710","https://openalex.org/W2010358741","https://openalex.org/W2011820509","https://openalex.org/W2020824027","https://openalex.org/W2039433262","https://openalex.org/W2041896131","https://openalex.org/W2067381415","https://openalex.org/W2086922132","https://openalex.org/W2136660295","https://openalex.org/W2154228327","https://openalex.org/W2188702955","https://openalex.org/W2210210991","https://openalex.org/W2211924732","https://openalex.org/W2282054059","https://openalex.org/W2397217777","https://openalex.org/W2398806689","https://openalex.org/W2419852269","https://openalex.org/W2433347163","https://openalex.org/W2585669458","https://openalex.org/W2763164948","https://openalex.org/W6601218660","https://openalex.org/W6712409287","https://openalex.org/W6745534095","https://openalex.org/W7019466281"],"related_works":["https://openalex.org/W2020824027","https://openalex.org/W1580479508","https://openalex.org/W1674048610","https://openalex.org/W1570847980","https://openalex.org/W2016942754","https://openalex.org/W2002719254","https://openalex.org/W1575532099","https://openalex.org/W1537281682","https://openalex.org/W2585669458","https://openalex.org/W1571691915"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}