{"id":"https://openalex.org/W2010281083","doi":"https://doi.org/10.1089/aid.1998.14.151","title":"Short Communication : Immunogenicity of DNA Vaccines Expressing Human Immunodeficiency Virus Type 1 Envelope Glycoprotein with and without Deletions in the V1/2 and V3 Regions","display_name":"Short Communication : Immunogenicity of DNA Vaccines Expressing Human Immunodeficiency Virus Type 1 Envelope Glycoprotein with and without Deletions in the V1/2 and V3 Regions","publication_year":1998,"publication_date":"1998-01-20","ids":{"openalex":"https://openalex.org/W2010281083","doi":"https://doi.org/10.1089/aid.1998.14.151","mag":"2010281083","pmid":"https://pubmed.ncbi.nlm.nih.gov/9462925"},"language":"en","primary_location":{"id":"doi:10.1089/aid.1998.14.151","doi":"https://doi.org/10.1089/aid.1998.14.151","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.1998.14.151","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101424241","display_name":"Shan L\u00fc","orcid":"https://orcid.org/0000-0001-8582-3206","observed_orcids":["https://orcid.org/0000-0001-8582-3206"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SHAN LU","raw_affiliation_strings":["Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037123473","display_name":"Richard T. Wyatt","orcid":"https://orcid.org/0000-0001-7085-1351","observed_orcids":["https://orcid.org/0000-0001-7085-1351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RICHARD WYATT","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014661224","display_name":"Joan F. L. Richmond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOAN F.L. RICHMOND","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083606632","display_name":"Farah Mustafa","orcid":"https://orcid.org/0000-0002-1081-3756","observed_orcids":["https://orcid.org/0000-0002-1081-3756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FARAH MUSTAFA","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059709620","display_name":"S. Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SHIXIA WANG","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044620346","display_name":"Jiayu Weng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JIAYU WENG","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004036928","display_name":"David C. Montefiori","orcid":"https://orcid.org/0000-0003-0856-6319","observed_orcids":["https://orcid.org/0000-0003-0856-6319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DAVID C. MONTEFIORI","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071476197","display_name":"Joseph Sodroski","orcid":"https://orcid.org/0000-0002-9750-1615","observed_orcids":["https://orcid.org/0000-0002-9750-1615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOSEPH SODROSKI","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038292231","display_name":"Harriet L. Robinson","orcid":"https://orcid.org/0000-0001-6380-3458","observed_orcids":["https://orcid.org/0000-0001-6380-3458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HARRIET L. ROBINSON","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.99,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.72883295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"2","first_page":"151","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hiv-1-envelope-glycoprotein","display_name":"HIV-1 envelope glycoprotein","score":0.9800000190734863},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gp140","display_name":"gp140","score":0.968999981880188},{"id":"https://openalex.org/keywords/gp160","display_name":"gp160","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cd4-binding-site","display_name":"CD4 binding site","score":0.9710000157356262},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8661837577819824},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7373777627944946},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6270671486854553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5891054272651672},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.5691540241241455},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4961799085140228},{"id":"https://openalex.org/C65155139","wikidata":"https://www.wikidata.org/wiki/Q5380912","display_name":"Envelope (radar)","level":3,"score":0.49605879187583923},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.47454819083213806},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.45847561955451965},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4356222450733185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.382008820772171},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.27132749557495117},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08971822261810303},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.08575519919395447},{"id":"https://openalex.org/C554190296","wikidata":"https://www.wikidata.org/wiki/Q47528","display_name":"Radar","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015686","descriptor_name":"Gene Products, env","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015686","descriptor_name":"Gene Products, env","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019302","descriptor_name":"HIV Envelope Protein gp160","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019302","descriptor_name":"HIV Envelope Protein gp160","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054299","descriptor_name":"env Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/aid.1998.14.151","doi":"https://doi.org/10.1089/aid.1998.14.151","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.1998.14.151","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},{"id":"pmid:9462925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9462925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS research and human retroviruses","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:gsbs_sp-1788","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gsbs_sp/789","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Morningside Graduate School of Biomedical Sciences Student Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1848338996","display_name":null,"funder_award_id":"5-T32 AI 07272-12","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3635714355","display_name":"Virus Infections: Pathogenesis and Host Immune Responses","funder_award_id":"T32AI007272","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4410682947","display_name":null,"funder_award_id":"R01 AI34241","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G527373959","display_name":null,"funder_award_id":"NCI-6S-1649","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"},{"id":"https://openalex.org/G8431329000","display_name":"SERIAL PATIENT ENVS AS TARGETS &STIMULATORS OF ANTIBODY","funder_award_id":"7r01ai034241-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1656939007","https://openalex.org/W1762774688","https://openalex.org/W1778074134","https://openalex.org/W1981347164","https://openalex.org/W1991933020","https://openalex.org/W1994537350","https://openalex.org/W2008493977","https://openalex.org/W2014922422","https://openalex.org/W2015404088","https://openalex.org/W2028215634","https://openalex.org/W2047472099","https://openalex.org/W2051005349","https://openalex.org/W2057344118","https://openalex.org/W2069851285","https://openalex.org/W2072516660","https://openalex.org/W2078809586","https://openalex.org/W2103765613","https://openalex.org/W2124195126"],"related_works":["https://openalex.org/W2023162377","https://openalex.org/W2049873788","https://openalex.org/W2033223557","https://openalex.org/W2157631793","https://openalex.org/W2122061948","https://openalex.org/W2160056486","https://openalex.org/W2085662163","https://openalex.org/W7097676405","https://openalex.org/W2046325186","https://openalex.org/W2124195126"],"abstract_inverted_index":{"DNA":[0,84,94],"vaccines":[1],"that":[2,124,161,170],"express":[3],"the":[4,19,29,49,54,60,68,74,79,82,90,97,104,107,114,129,134,138,142,150,163,172,180],"human":[5],"immunodeficiency":[6],"virus":[7],"type":[8],"1":[9],"HXB-2":[10],"envelope":[11],"glycoprotein":[12],"(Env)":[13],"with":[14],"or":[15,92],"without":[16],"deletions":[17],"of":[18,48,64,71,76,106,113,131,152,165,168,182],"major":[20],"variable":[21,80,101,115,135],"regions":[22,102,116],"V1/V2":[23,143],"and":[24,37,66,99,109,144],"V3":[25,100,145],"were":[26,51,125],"tested":[27],"for":[28],"ability":[30,151],"to":[31,154],"raise":[32,155],"enzyme-linked":[33],"immunosorbent":[34],"assay":[35],"(ELISA)":[36],"neutralizing":[38,156,184],"antibody":[39,120],"in":[40,119,179],"New":[41],"Zealand":[42],"White":[43],"(NZW)":[44],"rabbits.":[45],"Three":[46],"forms":[47,75,130],"Envs":[50],"examined:":[52],"gp120,":[53],"surface":[55],"(SU)":[56],"receptor-binding":[57],"domain;":[58],"gp140,":[59],"entire":[61],"extracellular":[62],"domain":[63],"Env;":[65],"gp160,":[67],"complete":[69],"form":[70],"Env.":[72],"For":[73],"Env":[77,132,153,169],"containing":[78,133],"regions,":[81],"gp120-expressing":[83],"plasmid":[85],"was":[86],"more":[87],"immunogenic":[88],"than":[89],"gp140-":[91,108],"gp160-expressing":[93,110],"plasmids.":[95],"Removing":[96],"V1/2":[98],"increased":[103],"immunogenicity":[105],"DNAs.":[111],"Deletion":[112],"also":[117],"resulted":[118],"responses":[121],"against":[122],"determinants":[123],"not":[126,148,176],"presented":[127],"by":[128],"regions.":[136],"Despite":[137],"improved":[139],"immunogenicity,":[140],"removing":[141],"domains":[146],"did":[147],"improve":[149],"antibodies.":[157],"These":[158],"results":[159],"suggest":[160],"increasing":[162],"exposure":[164],"internal":[166],"structures":[167],"include":[171],"CD4-binding":[173],"site":[174],"does":[175],"necessarily":[177],"result":[178],"generation":[181],"better":[183],"antibody.":[185]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}