{"id":"https://openalex.org/W2010263174","doi":"https://doi.org/10.1172/jci109669","title":"Enterohepatic physiology of 1,25-dihydroxyvitamin D3.","display_name":"Enterohepatic physiology of 1,25-dihydroxyvitamin D3.","publication_year":1980,"publication_date":"1980-02-01","ids":{"openalex":"https://openalex.org/W2010263174","doi":"https://doi.org/10.1172/jci109669","mag":"2010263174","pmid":"https://pubmed.ncbi.nlm.nih.gov/7356679","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/371364"},"language":"en","primary_location":{"id":"doi:10.1172/jci109669","doi":"https://doi.org/10.1172/jci109669","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109669","pdf_url":"http://www.jci.org/articles/view/109669/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/109669/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100605270","display_name":"Rajiv Kumar","orcid":"https://orcid.org/0000-0003-3497-3057","observed_orcids":["https://orcid.org/0000-0003-3497-3057"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Kumar","raw_affiliation_strings":["Research Uniit , Departfpeetmt of Mledicinie ,","anid Department of Molecular Medicine , Mayo Clintic and Founidationi , Rochester , Minnesota 55901","Nephrology and Hypertension"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Uniit , Departfpeetmt of Mledicinie ,","institution_ids":[]},{"raw_affiliation_string":"anid Department of Molecular Medicine , Mayo Clintic and Founidationi , Rochester , Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Nephrology and Hypertension","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037388302","display_name":"Sreeramulu Nagubandi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Nagubandi","raw_affiliation_strings":["Research Uniit , Departfpeetmt of Mledicinie ,","anid Department of Molecular Medicine , Mayo Clintic and Founidationi , Rochester , Minnesota 55901","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Uniit , Departfpeetmt of Mledicinie ,","institution_ids":[]},{"raw_affiliation_string":"anid Department of Molecular Medicine , Mayo Clintic and Founidationi , Rochester , Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114007463","display_name":"Vernon R. Mattox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V R Mattox","raw_affiliation_strings":["Research Uniit , Departfpeetmt of Mledicinie ,","anid Department of Molecular Medicine , Mayo Clintic and Founidationi , Rochester , Minnesota 55901","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Uniit , Departfpeetmt of Mledicinie ,","institution_ids":[]},{"raw_affiliation_string":"anid Department of Molecular Medicine , Mayo Clintic and Founidationi , Rochester , Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021098700","display_name":"James M. Londowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Londowski","raw_affiliation_strings":["Research Uniit , Departfpeetmt of Mledicinie ,","anid Department of Molecular Medicine , Mayo Clintic and Founidationi , Rochester , Minnesota 55901","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Uniit , Departfpeetmt of Mledicinie ,","institution_ids":[]},{"raw_affiliation_string":"anid Department of Molecular Medicine , Mayo Clintic and Founidationi , Rochester , Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":11.4624,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.98949737,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"65","issue":"2","first_page":"277","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vitamin-d-metabolites","display_name":"vitamin D metabolites","score":0.7490000128746033},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/polar-metabolites","display_name":"polar metabolites","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2778620825","wikidata":"https://www.wikidata.org/wiki/Q1344633","display_name":"Enterohepatic circulation","level":3,"score":0.8020809292793274},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7223497629165649},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5084515810012817},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4736700654029846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.398357093334198}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004100","descriptor_name":"Dihydroxycholecalciferols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004764","descriptor_name":"Enterohepatic Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006887","descriptor_name":"Hydroxycholecalciferols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci109669","doi":"https://doi.org/10.1172/jci109669","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109669","pdf_url":"http://www.jci.org/articles/view/109669/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:371364","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/371364","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:7356679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7356679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci109669","doi":"https://doi.org/10.1172/jci109669","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109669","pdf_url":"http://www.jci.org/articles/view/109669/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8583273390","display_name":"THE PHYSIOLOGY AND METABOLISM OF VITAMIN D","funder_award_id":"R01DK025409","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306146","display_name":"Andrew W. Mellon Foundation","ror":"https://ror.org/04jsh2530"},{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010263174.pdf","grobid_xml":"https://content.openalex.org/works/W2010263174.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W49403671","https://openalex.org/W1602537057","https://openalex.org/W1966321362","https://openalex.org/W1988341396","https://openalex.org/W2007615354","https://openalex.org/W2035460548","https://openalex.org/W2040693132","https://openalex.org/W2091079066","https://openalex.org/W2093827598","https://openalex.org/W2098760172","https://openalex.org/W2148708314","https://openalex.org/W2334609195","https://openalex.org/W2403760180"],"related_works":["https://openalex.org/W245588570","https://openalex.org/W1029628222","https://openalex.org/W2073307552","https://openalex.org/W2462089281","https://openalex.org/W2040695645","https://openalex.org/W2118990936","https://openalex.org/W2014236754","https://openalex.org/W2522823346","https://openalex.org/W1979338694","https://openalex.org/W2334609195"],"abstract_inverted_index":{"After":[0],"intravenous":[1],"administration":[2],"of":[3,11,23,30,37,39,54,73,101,154,161,164,182,201,204],"radiolabeled":[4,134,165],"1,25-dihydroxyvitamin":[5,55,74,87,158,166,205],"D3":[6,56,75,88,167,206],"to":[7,81],"rats,":[8],"approximately":[9],"25%":[10],"the":[12,17,24,28,40,65,102,112,119,133,152,162,183,202,208],"administered":[13],"radioactivity":[14,26,41,103,155],"appeared":[15],"in":[16,42,59,64,77,105,151,168,207],"bile":[18,45,60,78,106,131,169],"within":[19,46],"24":[20,47],"h.":[21,48],"Instillation":[22],"biliary":[25],"into":[27,92,177,185],"duodena":[29],"other":[31],"rats":[32],"was":[33,61,107,136,148],"followed":[34],"by":[35,51,110],"recovery":[36],"15%":[38],"newly":[43],"secreted":[44],"The":[49,71],"process":[50],"which":[52,174],"products":[53,163,203],"were":[57,79,90],"excreted":[58],"not":[62],"saturable":[63],"dose":[66],"range":[67],"tested":[68],"(0.275-650":[69],"ng).":[70],"metabolites":[72,135,184],"present":[76,104],"found":[80],"be":[82,116],"much":[83],"more":[84],"polar":[85,188],"than":[86],"and":[89,142],"resolved":[91],"three":[93],"fractions":[94],"on":[95],"high":[96,127],"performance":[97],"liquid":[98],"chromatography.":[99],"60%":[100],"retained":[108],"selectively":[109],"DEAE-cellulose;":[111],"radioactive":[113],"material":[114],"could":[115],"eluted":[117],"from":[118],"gel":[120],"at":[121,126,138],"a":[122,186,196],"low":[123],"pH":[124,143],"or":[125],"salt":[128],"concentrations.":[129],"When":[130],"containing":[132],"incubated":[137],"37":[139],"degrees":[140],"C":[141],"5":[144],"with":[145,157,170],"beta-glucuronidase,":[146],"there":[147,194],"an":[149,172],"increase":[150],"amount":[153],"comigrating":[156],"D3.":[159],"Treatment":[160],"diazomethane,":[171],"agent":[173],"converts":[175],"acids":[176],"methyl":[178],"esters,":[179],"transformed":[180],"one":[181],"less":[187],"compound.":[189],"These":[190],"results":[191],"demonstrate":[192],"that":[193],"is":[195],"quantitatively":[197],"important":[198],"enterophepatic":[199],"circulation":[200],"rat.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
