{"id":"https://openalex.org/W2010255267","doi":"https://doi.org/10.1111/j.1365-2249.1994.tb06609.x","title":"Circulating proinflammatory cytokines (IL-1\u03b2, TNF-\u03b1, and IL-6) and IL-1 receptor antagonist (IL-1Ra) in fulminant hepatic failure and acute hepatitis","display_name":"Circulating proinflammatory cytokines (IL-1\u03b2, TNF-\u03b1, and IL-6) and IL-1 receptor antagonist (IL-1Ra) in fulminant hepatic failure and acute hepatitis","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2010255267","doi":"https://doi.org/10.1111/j.1365-2249.1994.tb06609.x","mag":"2010255267","pmid":"https://pubmed.ncbi.nlm.nih.gov/7923888","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534161"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.1994.tb06609.x","doi":"https://doi.org/10.1111/j.1365-2249.1994.tb06609.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.1994.tb06609.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052084750","display_name":"Kazuhiko Sekiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210156626","display_name":"SHOWA Medical University Fujigaoka Hospital","ror":"https://ror.org/0543mcr22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210156626"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"K D SEKIYAMA","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA","Division of Gastroenterology, Department of Medicine. Showa University Fujigaoka Hospital, Yokohama City, Japan","Pittsburgh Transplantation Institute, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine. Showa University Fujigaoka Hospital, Yokohama City, Japan","institution_ids":["https://openalex.org/I4210156626"]},{"raw_affiliation_string":"Pittsburgh Transplantation Institute, Pittsburgh, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109924547","display_name":"M Yoshiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156626","display_name":"SHOWA Medical University Fujigaoka Hospital","ror":"https://ror.org/0543mcr22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210156626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M YOSHIBA","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine. Showa University Fujigaoka Hospital, Yokohama City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine. Showa University Fujigaoka Hospital, Yokohama City, Japan","institution_ids":["https://openalex.org/I4210156626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069651723","display_name":"Angus W. Thomson","orcid":"https://orcid.org/0000-0001-6731-8871","observed_orcids":["https://orcid.org/0000-0001-6731-8871"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A W THOMSON","raw_affiliation_strings":["Department of Molecular Genetics & Biochemistry, University of Pittsburgh Medical Center, Pittsburgh, USA","Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA","Pittsburgh Transplantation Institute, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics & Biochemistry, University of Pittsburgh Medical Center, Pittsburgh, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Pittsburgh Transplantation Institute, Pittsburgh, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069651723"],"corresponding_institution_ids":["https://openalex.org/I4210134769"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":1.1028,"has_fulltext":false,"cited_by_count":181,"citation_normalized_percentile":{"value":0.77770801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"98","issue":"1","first_page":"71","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.18520000576972961,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-hepatitis","display_name":"acute hepatitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hepatocyte-regeneration","display_name":"hepatocyte regeneration","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cytokine-cascade","display_name":"cytokine cascade","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5720000267028809},{"id":"https://openalex.org/keywords/cytokine-antagonists","display_name":"cytokine antagonists","score":0.8539999723434448},{"id":"https://openalex.org/keywords/liver-necroinflammation","display_name":"liver necroinflammation","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2911118192","wikidata":"https://www.wikidata.org/wiki/Q1192530","display_name":"Fulminant hepatic failure","level":4,"score":0.7506966590881348},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7355839014053345},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6572099924087524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5751585960388184},{"id":"https://openalex.org/C2781107259","wikidata":"https://www.wikidata.org/wiki/Q5508364","display_name":"Fulminant","level":2,"score":0.5666590929031372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5611398816108704},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.53956139087677},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.5298884510993958},{"id":"https://openalex.org/C149892131","wikidata":"https://www.wikidata.org/wiki/Q14914156","display_name":"Interleukin 1 receptor antagonist","level":5,"score":0.5093994736671448},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45740440487861633},{"id":"https://openalex.org/C2994395758","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Fulminant hepatitis","level":3,"score":0.4490184187889099},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.42878013849258423},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4183264970779419},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41339343786239624},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.29235196113586426},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2862134575843811},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2762969732284546},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.2292931079864502},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.1578681766986847}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006525","descriptor_name":"Hepatitis, Viral, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2249.1994.tb06609.x","doi":"https://doi.org/10.1111/j.1365-2249.1994.tb06609.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.1994.tb06609.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1534161","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534161","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:7923888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7923888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1534161","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534161","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G126774863","display_name":null,"funder_award_id":"DK 29961-09","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1489845893","https://openalex.org/W1497298414","https://openalex.org/W1544353554","https://openalex.org/W1574330564","https://openalex.org/W1855316965","https://openalex.org/W1964349627","https://openalex.org/W1965322074","https://openalex.org/W1971911112","https://openalex.org/W1972689256","https://openalex.org/W1974652824","https://openalex.org/W1978745104","https://openalex.org/W1989658278","https://openalex.org/W1995438622","https://openalex.org/W1999921831","https://openalex.org/W2016531336","https://openalex.org/W2025489827","https://openalex.org/W2025517694","https://openalex.org/W2026555524","https://openalex.org/W2035274613","https://openalex.org/W2036332752","https://openalex.org/W2040930510","https://openalex.org/W2046196550","https://openalex.org/W2048656662","https://openalex.org/W2061554884","https://openalex.org/W2062908277","https://openalex.org/W2070737639","https://openalex.org/W2073598149","https://openalex.org/W2093751409","https://openalex.org/W2106012039","https://openalex.org/W2119790306","https://openalex.org/W2119997031","https://openalex.org/W2123601573","https://openalex.org/W2126726439","https://openalex.org/W2140911983","https://openalex.org/W2207000773","https://openalex.org/W2242850553","https://openalex.org/W2332739634","https://openalex.org/W2336081198","https://openalex.org/W2404122132","https://openalex.org/W2415856156","https://openalex.org/W2417501314","https://openalex.org/W2608256706","https://openalex.org/W6713406490","https://openalex.org/W6716422408"],"related_works":["https://openalex.org/W2283629365","https://openalex.org/W2108138347","https://openalex.org/W2053021755","https://openalex.org/W2021579652","https://openalex.org/W2052136116","https://openalex.org/W7017684902","https://openalex.org/W2605730475","https://openalex.org/W2071268435","https://openalex.org/W2757195376","https://openalex.org/W2058836044"],"abstract_inverted_index":{"Fulminant":[0],"hepatic":[1],"failure":[2,167],"(FHF)":[3],"is":[4,14,144],"characterized":[5],"by":[6],"massive":[7],"necroinflammation":[8],"of":[9,21,51,59,84,92,120,128,161,213,219],"the":[10,78,147,159,191,209,217],"liver":[11],"tissue":[12],"and":[13,29,41,53,87,113,165,190],"associated":[15],"with":[16,39,45,69,108,118,203],"high":[17,183],"mortality.":[18],"Serum":[19],"concentrations":[20,115],"IL-1":[22,30,85,95],"beta,":[23],"tumour":[24],"necrosis":[25],"factor-alpha":[26],"(TNF-alpha),":[27],"IL-6":[28,114],"receptor":[31],"antagonist":[32],"(IL-1Ra)":[33],"were":[34,63,74,99,116],"measured":[35],"in":[36,42,54,66,71,77,101,150,154,187,197],"30":[37],"patients":[38,44,103,138,189,199],"FHF":[40,67,102,155,198],"23":[43,55],"acute":[46],"hepatitis":[47,162],"(AH)":[48],"before":[49],"start":[50],"treatment":[52],"healthy":[56,79],"controls.":[57,80],"Levels":[58],"all":[60],"four":[61],"molecules":[62],"increased":[64],"significantly":[65,89,192],"compared":[68,107,202],"AH,":[70],"which":[72],"values":[73],"higher":[75],"than":[76,180],"High":[81],"serum":[82,132],"levels":[83,119,134,153,185],"beta":[86,96,195],"a":[88,166,170],"reduced":[90],"ratio":[91,196],"IL-1Ra":[93],"to":[94,168,175],"(IL-1Ra/IL-1":[97],"beta)":[98],"observed":[100,186],"who":[104,110,200,205],"subsequently":[105],"died":[106],"subjects":[109],"survived.":[111],"TNF-alpha":[112],"correlated":[117],"human":[121],"hepatocyte":[122,129,177],"growth":[123],"factor":[124],"(hHGF),":[125],"an":[126],"index":[127],"regeneration.":[130,181],"Although":[131],"cytokine":[133,152,172,184,214],"varied":[135],"considerably":[136],"between":[137],"within":[139],"each":[140],"group":[141],"studied,":[142],"it":[143],"suggested":[145],"that":[146],"striking":[148],"elevation":[149],"proinflammatory":[151],"may":[156],"reflect":[157],"both":[158],"insufficiency":[160],"virus":[163],"elimination":[164],"control":[169,218],"vicious":[171],"cascade":[173],"leading":[174],"overwhelming":[176],"destruction":[178],"rather":[179],"The":[182],"these":[188],"elevated":[193],"IL-1Ra/IL-1":[194],"survived":[201],"those":[204],"did":[206],"not":[207],"suggest":[208],"possible":[210],"therapeutic":[211],"use":[212],"antagonists":[215],"for":[216],"this":[220],"life-threatening":[221],"disease.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
