{"id":"https://openalex.org/W2010238913","doi":"https://doi.org/10.1097/00007890-199103000-00007","title":"SIGNIFICANCE OF BIOCHEMICAL MARKERS IN EARLY DETECTION OF CANINE LUNG ALLOGRAFT REJECTION","display_name":"SIGNIFICANCE OF BIOCHEMICAL MARKERS IN EARLY DETECTION OF CANINE LUNG ALLOGRAFT REJECTION","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W2010238913","doi":"https://doi.org/10.1097/00007890-199103000-00007","mag":"2010238913","pmid":"https://pubmed.ncbi.nlm.nih.gov/1900961"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199103000-00007","doi":"https://doi.org/10.1097/00007890-199103000-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199103000-00007","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TRANSPLANTATION","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102110958","display_name":"Shi-Chuan Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"SHI-CHUAN CHANG","raw_affiliation_strings":["Department of Chest, Veterans General Hospital-Taipei, VACRS, Taiwan, Republic of China","Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest, Veterans General Hospital-Taipei, VACRS, Taiwan, Republic of China","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035097612","display_name":"Hon-Ki Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"HON-KI HSU","raw_affiliation_strings":["Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","and Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"and Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004217843","display_name":"Reury-Perng Perng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"REURY-PERNG PERNG","raw_affiliation_strings":["Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","and Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"and Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110132689","display_name":"Guang-Ming Shiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"GUANG-MING SHIAO","raw_affiliation_strings":["Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","and Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"and Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066929308","display_name":"Ching\u2010Yuang Lin","orcid":"https://orcid.org/0000-0003-4820-5200","observed_orcids":["https://orcid.org/0000-0003-4820-5200"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"CHING-YUANG LIN","raw_affiliation_strings":["Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","and Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chest, Medical Research and Pediatrics, and Section of Thoracic Surgery, Veterans General Hospital-Taipei, VACRS","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"and Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2803004286"],"apc_list":null,"apc_paid":null,"fwci":2.5372,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88388735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"51","issue":"3","first_page":"579","last_page":"583"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rejection","display_name":"rejection","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-fluid","display_name":"bronchoalveolar lavage fluid","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.878000020980835},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/soluble-il-2-receptor","display_name":"soluble interleukin-2 receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9399999976158142},{"id":"https://openalex.org/keywords/early-detection-of-rejection","display_name":"early rejection detection","score":0.7429999709129333},{"id":"https://openalex.org/keywords/immunosuppression-monitoring","display_name":"immunosuppression monitoring","score":0.6119999885559082},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.38199999928474426},{"id":"https://openalex.org/keywords/chest-x-ray-abnormalities","display_name":"chest X-ray abnormalities","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.8835931420326233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7596724629402161},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.7369555830955505},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7194290161132812},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6456934809684753},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.4822419583797455},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4653848707675934},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4438965618610382},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3952335715293884},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3946658968925476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3459513187408447}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016040","descriptor_name":"Lung Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016040","descriptor_name":"Lung Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199103000-00007","doi":"https://doi.org/10.1097/00007890-199103000-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199103000-00007","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TRANSPLANTATION","raw_type":"journal-article"},{"id":"pmid:1900961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1900961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031581417","https://openalex.org/W2132711268","https://openalex.org/W1993661249","https://openalex.org/W2410453448","https://openalex.org/W1999929872","https://openalex.org/W6998913993","https://openalex.org/W2014781659","https://openalex.org/W2494950277","https://openalex.org/W1991752403","https://openalex.org/W1941717751"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,136,158,176,193,201,209,213,228,254,264,270,301,305,336,345],"significance":[3],"of":[4,9,24,55,84,109,116,126,148,167,221,230,233,250,263,272,283,288,296,307,322,339,348,354],"bronchoalveolar":[5,29],"lavage":[6],"fluid,":[7],"levels":[8,147,220,249,287,295,321],"tumor":[10],"necrosis":[11],"factor-alpha":[12],"(TNF),":[13],"gamma-interferon,":[14],"interleukin":[15],"2,":[16],"and":[17,38,130,142,224,266,326,343],"soluble":[18],"IL-2":[19],"receptor":[20],"in":[21,34,57,132,139,170,175,189,227,235,334,344,357],"early":[22,346],"detection":[23,347],"canine":[25,340],"lung":[26,41,93,341,349,359],"allograft":[27,350,360],"rejection,":[28],"lavages":[30],"were":[31,45,64,75,100,151,197,203,217,257],"performed":[32],"serially":[33,318],"mongrel":[35],"dogs":[36,44,63,234],"before":[37],"after":[39,119,182,275,281],"single":[40,82,92,107],"transplantation.":[42,94,121,184,277],"The":[43,146,352],"divided":[46],"into":[47],"three":[48,168],"groups.":[49],"Group":[50],"1":[51,141,237],"(control":[52],"group)":[53,72],"consisted":[54],"one":[56],"which":[58],"neither":[59],"donor":[60],"nor":[61],"recipient":[62],"treated":[65,76,101],"with":[66,77,102],"cyclosporine.":[67],"In":[68,95,245],"group":[69,96,140,143,171,236,239,246],"2":[70,144,172,240],"(CsA-pretreated":[71],"only":[73,98],"donors":[74],"CsA":[78,103,273,284],"orally":[79,104],"at":[80,105,212],"a":[81,106,113,331],"dose":[83,108],"20":[85,110],"mg/kg/day":[86,111],"for":[87,112],"3":[88,97],"days":[89,118,280],"prior":[90],"to":[91,292],"recipients":[99,169],"short":[114],"period":[115,271],"9":[117],"single-lung":[120,183,276],"Marked":[122],"elevation":[123],"was":[124],"found":[125],"TNF,":[127,222,323],"IFN-gamma,":[128,324],"IL-2,":[129,223,325],"IL-2R":[131,225,327],"BALF":[133,190,229,248,286,297,320,355],"obtained":[134,156,191,207,299],"from":[135,157,192,208,253,261,300,362],"grafted":[137,210,231,255,302],"lungs":[138,161,178,196,211,232,256,268,303],"dogs.":[145],"these":[149,251],"markers":[150,186,252,290,298],"significantly":[152,218,259],"higher":[153,219],"than":[154,164,205,238,243],"those":[155,206,262],"normal,":[159],"native":[160,177,195,267],"(P":[162,241],"less":[163,204,242],"0.05).":[165,244],"Two":[166],"had":[173],"pneumonia":[174],"on":[179],"day":[180],"10":[181],"All":[185],"except":[187],"IFN-gamma":[188,356],"infected":[194],"also":[198],"increased,":[199],"but":[200],"titers":[202],"same":[214],"time.":[215],"There":[216],"present":[226],"3,":[247],"not":[258],"different":[260],"normal":[265],"during":[269],"treatment":[274],"On":[278],"various":[279],"discontinuation":[282],"treatment,":[285],"all":[289],"began":[291],"rise.":[293],"Abnormal":[294],"heralded":[304],"appearance":[306],"abnormalities":[308],"detected":[309],"by":[310],"chest":[311],"x-ray":[312],"films.":[313],"Our":[314],"study":[315],"suggests":[316],"that":[317],"measuring":[319],"may":[328],"serve":[329],"as":[330],"useful":[332],"means":[333],"monitoring":[335],"immunologic":[337],"status":[338],"allografts":[342],"rejection.":[351],"role":[353],"distinguishing":[358],"rejection":[361],"pulmonary":[363],"infection":[364],"needs":[365],"further":[366],"studies.":[367]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
