{"id":"https://openalex.org/W2010235267","doi":"https://doi.org/10.1016/0022-3956(86)90021-x","title":"Familial aggregation in Alzheimer dementia\u2014I. A model for the age-dependent expression of an autosomal dominant gene","display_name":"Familial aggregation in Alzheimer dementia\u2014I. A model for the age-dependent expression of an autosomal dominant gene","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2010235267","doi":"https://doi.org/10.1016/0022-3956(86)90021-x","mag":"2010235267","pmid":"https://pubmed.ncbi.nlm.nih.gov/3712289"},"language":"en","primary_location":{"id":"doi:10.1016/0022-3956(86)90021-x","doi":"https://doi.org/10.1016/0022-3956(86)90021-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-3956(86)90021-x","pdf_url":null,"source":{"id":"https://openalex.org/S160879026","display_name":"Journal of Psychiatric Research","issn_l":"0022-3956","issn":["0022-3956","1879-1379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057796570","display_name":"John C.S. Breitner","orcid":"https://orcid.org/0000-0003-4229-4687","observed_orcids":["https://orcid.org/0000-0003-4229-4687"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John C.S. Breitner","raw_affiliation_strings":["Department of Psychiatry, Bronx VA Medical Center, and The Mount Sinai School of Medicine, The Johns Hopkins Medical Institutions, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Bronx VA Medical Center, and The Mount Sinai School of Medicine, The Johns Hopkins Medical Institutions, USA","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111919977","display_name":"Marshal F. Folstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marshal F. Folstein","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, The Johns Hopkins Medical Institutions, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, The Johns Hopkins Medical Institutions, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112787150","display_name":"Edmond A. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmond A. Murphy","raw_affiliation_strings":["Division of Medical Genetics, Department of Medicine, The Johns Hopkins Medical Institutions, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Medicine, The Johns Hopkins Medical Institutions, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057796570"],"corresponding_institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I98704320"],"apc_list":{"value":3320,"currency":"USD","value_usd":3320},"apc_paid":null,"fwci":13.6977,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.99166595,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"31","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.800000011920929},{"id":"https://openalex.org/keywords/familial-aggregation","display_name":"familial aggregation","score":0.984000027179718},{"id":"https://openalex.org/keywords/autosomal-dominant-inheritance","display_name":"autosomal dominant inheritance","score":0.984000027179718},{"id":"https://openalex.org/keywords/age-related-gene-expression","display_name":"age-related gene expression","score":0.9150000214576721},{"id":"https://openalex.org/keywords/genetic-transmission","display_name":"genetic transmission","score":0.5740000009536743},{"id":"https://openalex.org/keywords/familial-risk","display_name":"familial risk","score":0.6309999823570251},{"id":"https://openalex.org/keywords/phenocopy","display_name":"phenocopy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/late-onset-disease","display_name":"late-onset disease","score":0.6809999942779541},{"id":"https://openalex.org/keywords/age-specific-incidence","display_name":"age-specific incidence","score":0.5929999947547913},{"id":"https://openalex.org/keywords/relatives","display_name":"relatives","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C12387725","wikidata":"https://www.wikidata.org/wiki/Q937024","display_name":"Phenocopy","level":4,"score":0.8619194030761719},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.7551483511924744},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.6577756404876709},{"id":"https://openalex.org/C203083617","wikidata":"https://www.wikidata.org/wiki/Q5433302","display_name":"Family aggregation","level":3,"score":0.6314325332641602},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5997836589813232},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5872675776481628},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.5215327739715576},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4907556474208832},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.45025765895843506},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.423380970954895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3868095874786377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3499389588832855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34856438636779785},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2525451183319092},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16573795676231384},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.07216259837150574}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001037","descriptor_name":"Aphasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001072","descriptor_name":"Apraxias","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-3956(86)90021-x","doi":"https://doi.org/10.1016/0022-3956(86)90021-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-3956(86)90021-x","pdf_url":null,"source":{"id":"https://openalex.org/S160879026","display_name":"Journal of Psychiatric Research","issn_l":"0022-3956","issn":["0022-3956","1879-1379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychiatric Research","raw_type":"journal-article"},{"id":"pmid:3712289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3712289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatric research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1556967679","display_name":null,"funder_award_id":"NSPO-1-16375-03","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W630809587","https://openalex.org/W1924305245","https://openalex.org/W1975085041","https://openalex.org/W1984542334","https://openalex.org/W1990338514","https://openalex.org/W2016537454","https://openalex.org/W2025616315","https://openalex.org/W2032768837","https://openalex.org/W2034008058","https://openalex.org/W2041231034","https://openalex.org/W2055323770","https://openalex.org/W2067152525","https://openalex.org/W2083225032","https://openalex.org/W2094008246","https://openalex.org/W2099357463","https://openalex.org/W2102715685","https://openalex.org/W2114184378","https://openalex.org/W2126886481","https://openalex.org/W2156220037","https://openalex.org/W2293169181","https://openalex.org/W2323918049","https://openalex.org/W2324918355","https://openalex.org/W2410310409","https://openalex.org/W2466721750","https://openalex.org/W4232441794","https://openalex.org/W4235923981","https://openalex.org/W4251750451"],"related_works":["https://openalex.org/W2099357463","https://openalex.org/W1980740348","https://openalex.org/W2304592296","https://openalex.org/W7038010303","https://openalex.org/W1973139134","https://openalex.org/W1970890361","https://openalex.org/W4238170555","https://openalex.org/W2031895045","https://openalex.org/W2024737628","https://openalex.org/W2006623537"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
