{"id":"https://openalex.org/W2010229759","doi":"https://doi.org/10.1111/j.1471-4159.1981.tb01635.x","title":"Uptake of Amino Acids by Brain Microvessels Isolated from Rats after Portacaval Anastomosis","display_name":"Uptake of Amino Acids by Brain Microvessels Isolated from Rats after Portacaval Anastomosis","publication_year":1981,"publication_date":"1981-02-01","ids":{"openalex":"https://openalex.org/W2010229759","doi":"https://doi.org/10.1111/j.1471-4159.1981.tb01635.x","mag":"2010229759","pmid":"https://pubmed.ncbi.nlm.nih.gov/7463080"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1981.tb01635.x","doi":"https://doi.org/10.1111/j.1471-4159.1981.tb01635.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1981.tb01635.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079174277","display_name":"Patrizia Cardelli\u2010Cangiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrizia Cardelli\u2010Cangiano","raw_affiliation_strings":["Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012995127","display_name":"C. Cangiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo Cangiano","raw_affiliation_strings":["Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113828489","display_name":"J. Howard James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Howard James","raw_affiliation_strings":["Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067646984","display_name":"Bengt W. Jeppsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bengt Jeppsson","raw_affiliation_strings":["Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Brenner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Brenner","raw_affiliation_strings":["Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073095140","display_name":"Josef E. Fischer","orcid":"https://orcid.org/0000-0001-7299-898X","observed_orcids":["https://orcid.org/0000-0001-7299-898X"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josef E. Fischer","raw_affiliation_strings":["Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Cincinnati General Hospital Division, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079174277"],"corresponding_institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":10.825,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.99320568,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"36","issue":"2","first_page":"627","last_page":"632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.049400001764297485,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amino-acid-absorption","display_name":"amino acid uptake","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cerebral-microvasculature","display_name":"cerebral microvasculature","score":0.9860000014305115},{"id":"https://openalex.org/keywords/portacaval-shunt","display_name":"portacaval shunt","score":0.9610000252723694},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neutral-amino-acids","display_name":"neutral amino acids","score":0.8759999871253967},{"id":"https://openalex.org/keywords/phenylalanine","display_name":"phenylalanine","score":0.8360000252723694},{"id":"https://openalex.org/keywords/leucine","display_name":"leucine","score":1.0},{"id":"https://openalex.org/keywords/lysine","display_name":"lysine","score":0.996999979019165},{"id":"https://openalex.org/keywords/uptake-kinetics","display_name":"uptake kinetics","score":0.621999979019165},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/portal-hypertension","display_name":"portal hypertension","score":0.4970000088214874},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2779342495","wikidata":"https://www.wikidata.org/wiki/Q7231383","display_name":"Portacaval shunt","level":4,"score":0.8657246232032776},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.7115033268928528},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7082663774490356},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.5567156672477722},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.5237781405448914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5009675025939941},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4743591547012329},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.4647376537322998},{"id":"https://openalex.org/C2780992748","wikidata":"https://www.wikidata.org/wiki/Q7231384","display_name":"Portacaval anastomosis","level":4,"score":0.4643350839614868},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.4573492407798767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4503619968891144},{"id":"https://openalex.org/C2778740566","wikidata":"https://www.wikidata.org/wiki/Q181136","display_name":"Glutamic acid","level":3,"score":0.44018206000328064},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41808032989501953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40486425161361694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24749243259429932},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22194015979766846},{"id":"https://openalex.org/C2778808290","wikidata":"https://www.wikidata.org/wiki/Q124604","display_name":"Portal hypertension","level":3,"score":0.0780717134475708},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.07550618052482605},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011167","descriptor_name":"Portacaval Shunt, Surgical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1981.tb01635.x","doi":"https://doi.org/10.1111/j.1471-4159.1981.tb01635.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1981.tb01635.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:7463080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7463080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","score":0.6000000238418579,"display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1737765280","https://openalex.org/W1775749144","https://openalex.org/W1968187794","https://openalex.org/W1994991276","https://openalex.org/W1997530163","https://openalex.org/W2012426220","https://openalex.org/W2015823682","https://openalex.org/W2019213597","https://openalex.org/W2024814607","https://openalex.org/W2034230809","https://openalex.org/W2047920129","https://openalex.org/W2062633588","https://openalex.org/W2068857017","https://openalex.org/W2073850907","https://openalex.org/W2097753578","https://openalex.org/W2121349600","https://openalex.org/W2132477897","https://openalex.org/W2141880403","https://openalex.org/W2149717535","https://openalex.org/W2151350796","https://openalex.org/W2166997341","https://openalex.org/W2183452160","https://openalex.org/W2346441059","https://openalex.org/W2401036727","https://openalex.org/W2404087985","https://openalex.org/W2470266932","https://openalex.org/W4252420159"],"related_works":["https://openalex.org/W2019213597","https://openalex.org/W2033899974","https://openalex.org/W7026625742","https://openalex.org/W4252420159","https://openalex.org/W2105811627","https://openalex.org/W2311492124","https://openalex.org/W2329873468","https://openalex.org/W2417843702","https://openalex.org/W3036795394","https://openalex.org/W2295130330"],"abstract_inverted_index":{"The":[0,129],"uptake":[1,92,102,109,123],"of":[2,10,71,78,91,122],"amino":[3,21,74,144],"acids":[4],"by":[5],"microvessels":[6,46,58,86,111],"isolated":[7,48,160],"from":[8,49,59,87,112],"brains":[9],"rats":[11,51,60,114],"was":[12],"studied.":[13],"Previous":[14],"studies":[15],"have":[16],"demonstrated":[17],"alterations":[18],"in":[19,27,36,42,110,126,134,157,159],"blood-brain":[20,38],"acid":[22,84,145],"transport":[23,137],"after":[24,63,147],"portacaval":[25,53,148],"shunt":[26,54,64,149],"rats.":[28],"In":[29],"order":[30],"to":[31],"elucidate":[32],"whether":[33],"such":[34,152],"changes":[35,133,153],"the":[37,43,119],"barrier":[39],"were":[40,47,124],"located":[41],"microvessels,":[44],"brain":[45,135,142],"both":[50,127],"with":[52,116],"and":[55,100,103,150],"controls.":[56,89],"Brain":[57],"2":[61],"weeks":[62],"operations":[65],"took":[66],"up":[67],"significantly":[68],"greater":[69],"amounts":[70],"14C-labeled":[72],"neutral":[73,143],"acids,":[75],"but":[76],"not":[77],"glutamic":[79],"acid,":[80],"lysine,":[81],"or":[82],"alpha-methylaminoisobutyric":[83],"than":[85],"sham-operated":[88],"Measurement":[90],"kinetics":[93],"showed":[94],"a":[95,104],"higher":[96],"Vmax":[97,106],"for":[98,107,140],"phenylalanine":[99],"leucine":[101],"lower":[105],"lysine":[108],"shunted":[113],"compared":[115],"control,":[117],"whereas":[118],"respective":[120],"Km's":[121],"similar":[125],"preparations.":[128],"results":[130],"suggest":[131],"that":[132,151],"microvessel":[136],"activity":[138],"account":[139],"altered":[141],"concentrations":[146],"can":[154],"be":[155],"studied":[156],"vitro":[158],"microvessels.":[161]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}