{"id":"https://openalex.org/W2010223774","doi":"https://doi.org/10.1128/aac.00085-09","title":"Population Pharmacokinetics of Ganciclovir after Intravenous Ganciclovir and Oral Valganciclovir Administration in Solid Organ Transplant Patients Infected with Cytomegalovirus","display_name":"Population Pharmacokinetics of Ganciclovir after Intravenous Ganciclovir and Oral Valganciclovir Administration in Solid Organ Transplant Patients Infected with Cytomegalovirus","publication_year":2009,"publication_date":"2009-09-08","ids":{"openalex":"https://openalex.org/W2010223774","doi":"https://doi.org/10.1128/aac.00085-09","mag":"2010223774","pmid":"https://pubmed.ncbi.nlm.nih.gov/19738014","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772326"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00085-09","doi":"https://doi.org/10.1128/aac.00085-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00085-09","pdf_url":"https://aac.asm.org/content/aac/53/11/4816.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aac.asm.org/content/aac/53/11/4816.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A. Calde\u0301s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Calde\u0301s","raw_affiliation_strings":["Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015153813","display_name":"Helena Colom","orcid":"https://orcid.org/0000-0002-7259-0199","observed_orcids":["https://orcid.org/0000-0002-7259-0199"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"H. Colom","raw_affiliation_strings":["Department of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Armendariz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Y. Armendariz","raw_affiliation_strings":["Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039025396","display_name":"Mar\u0131\u0301a J. Garrido","orcid":"https://orcid.org/0000-0003-3559-4710","observed_orcids":["https://orcid.org/0000-0003-3559-4710"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. J. Garrido","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087528420","display_name":"I\u00f1aki F. Troc\u00f3niz","orcid":"https://orcid.org/0000-0003-3700-8658","observed_orcids":["https://orcid.org/0000-0003-3700-8658"]},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"I. F. Troconiz","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038602580","display_name":"Salvador Gil\u2010Vernet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S. Gil-Vernet","raw_affiliation_strings":["Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088500660","display_name":"N\u00faria Lloberas","orcid":"https://orcid.org/0000-0002-3387-5757","observed_orcids":["https://orcid.org/0000-0002-3387-5757"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N. Lloberas","raw_affiliation_strings":["Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113603967","display_name":"Leonor Pou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L. Pou","raw_affiliation_strings":["Biochemistry Service, Hospital Vall D'Hebron, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Service, Hospital Vall D'Hebron, Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111555998","display_name":"C. Peraire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C. Peraire","raw_affiliation_strings":["Department of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075848442","display_name":"Josep Maria Grinyo","orcid":"https://orcid.org/0000-0002-7435-3808","observed_orcids":["https://orcid.org/0000-0002-7435-3808"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. M. Grinyo\u0301","raw_affiliation_strings":["Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Universitari de Bellvitge, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015153813"],"corresponding_institution_ids":["https://openalex.org/I71999127"],"apc_list":null,"apc_paid":null,"fwci":1.4575,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.82577611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"53","issue":"11","first_page":"4816","last_page":"4824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ganciclovir","display_name":"ganciclovir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/valganciclovir","display_name":"valganciclovir","score":1.0},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cytomegalovirus-infection","display_name":"cytomegalovirus infection","score":0.9259999990463257},{"id":"https://openalex.org/keywords/solid-organ-transplant-recipients","display_name":"solid organ transplant recipients","score":0.9539999961853027},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6840000152587891},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7730000019073486},{"id":"https://openalex.org/keywords/absorption-rate-constant","display_name":"absorption rate constant","score":0.574999988079071},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2776317777","wikidata":"https://www.wikidata.org/wiki/Q423384","display_name":"Valganciclovir","level":5,"score":0.9635802507400513},{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.9225553274154663},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7204696536064148},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.6559274792671204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5702640414237976},{"id":"https://openalex.org/C3020755252","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Population pharmacokinetics","level":3,"score":0.4889928102493286},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.43927866220474243},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42863601446151733},{"id":"https://openalex.org/C2910866203","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus infections","level":4,"score":0.4257742762565613},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3075793981552124},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.2766336500644684},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.26747843623161316},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.17165270447731018},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.1628875732421875},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077562","descriptor_name":"Valganciclovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D016377","descriptor_name":"Organ Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.00085-09","doi":"https://doi.org/10.1128/aac.00085-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00085-09","pdf_url":"https://aac.asm.org/content/aac/53/11/4816.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2772326","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772326","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:19738014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19738014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Clinical Trial"},{"id":"pmh:oai:dadun.unav.edu:10171/21704","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10171/21704","pdf_url":null,"source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1128/aac.00085-09","doi":"https://doi.org/10.1128/aac.00085-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00085-09","pdf_url":"https://aac.asm.org/content/aac/53/11/4816.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010223774.pdf","grobid_xml":"https://content.openalex.org/works/W2010223774.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W182370232","https://openalex.org/W1535918788","https://openalex.org/W1537857643","https://openalex.org/W1550111394","https://openalex.org/W1964594353","https://openalex.org/W1985591067","https://openalex.org/W1997456241","https://openalex.org/W2003303285","https://openalex.org/W2005815716","https://openalex.org/W2006583270","https://openalex.org/W2047636084","https://openalex.org/W2058734479","https://openalex.org/W2059185356","https://openalex.org/W2061219392","https://openalex.org/W2061974719","https://openalex.org/W2066464642","https://openalex.org/W2071991687","https://openalex.org/W2072491976","https://openalex.org/W2076864549","https://openalex.org/W2083668821","https://openalex.org/W2085476296","https://openalex.org/W2103016320","https://openalex.org/W2117897510","https://openalex.org/W2127763131","https://openalex.org/W2169496253","https://openalex.org/W2246750959","https://openalex.org/W2547115861","https://openalex.org/W2980345380","https://openalex.org/W4231692149","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2133714268","https://openalex.org/W1847510258","https://openalex.org/W2001016226","https://openalex.org/W1981693925","https://openalex.org/W2944884411","https://openalex.org/W2071991687","https://openalex.org/W2989649849","https://openalex.org/W2471634880","https://openalex.org/W4368358165","https://openalex.org/W3117926950"],"abstract_inverted_index":{"A":[0,47],"population":[1,94],"pharmacokinetics":[2],"analysis":[3],"was":[4,70,87,91,113,121,125,130,135],"performed":[5],"after":[6],"intravenous":[7],"ganciclovir":[8,21,84,153],"and":[9,30,56,100,107,127],"oral":[10],"valganciclovir":[11,35],"in":[12,75],"solid":[13],"organ":[14],"transplant":[15],"patients":[16],"with":[17,41,60],"cytomegalovirus.":[18],"Patients":[19],"received":[20],"at":[22],"5":[23,55],"mg/kg":[24],"of":[25,34,49,96,139],"body":[26],"weight":[27],"(5":[28],"days)":[29],"then":[31],"900":[32],"mg":[33],"(16":[36],"days),":[37],"both":[38],"twice":[39],"daily":[40],"dose":[42,142],"adjustment":[43,143],"for":[44],"renal":[45],"function.":[46],"total":[48],"382":[50],"serum":[51],"concentrations":[52],"from":[53],"days":[54],"15":[57],"were":[58,81,104],"analyzed":[59],"NONMEM":[61],"VI.":[62],"Renal":[63],"function":[64],"given":[65],"by":[66,144],"creatinine":[67],"clearance":[68,85,112],"(CL(CR))":[69],"the":[71,92,98,116,136,150],"most":[72,151],"influential":[73],"covariate":[74,146],"CL.":[76],"The":[77,133],"final":[78],"pharmacokinetic":[79],"parameters":[80],"as":[82],"follows:":[83],"(CL)":[86],"7.49.(CL(CR)/57)":[88],"liter/h":[89],"(57":[90],"mean":[93],"value":[95],"CL(CR));":[97],"central":[99],"peripheral":[101],"distribution":[102],"volumes":[103],"31.9":[105],"liters":[106],"32.0":[108],"liters,":[109],"respectively;":[110],"intercompartmental":[111],"10.2":[114],"liter/h;":[115],"first-order":[117],"absorption":[118],"rate":[119],"constant":[120],"0.895":[122],"h(-1);":[123],"bioavailability":[124],"0.825;":[126],"lag":[128],"time":[129],"0.382":[131],"h.":[132],"CL(CR)":[134],"best":[137],"predictor":[138],"CL,":[140],"making":[141],"this":[145],"important":[147],"to":[148],"achieve":[149],"efficacious":[152],"exposure.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}