{"id":"https://openalex.org/W2010221809","doi":"https://doi.org/10.1126/science.6402818","title":"Salt-Induced Conversion of B-DNA to Z-DNA Inhibited by Aflatoxin B1","display_name":"Salt-Induced Conversion of B-DNA to Z-DNA Inhibited by Aflatoxin B1","publication_year":1983,"publication_date":"1983-03-25","ids":{"openalex":"https://openalex.org/W2010221809","doi":"https://doi.org/10.1126/science.6402818","mag":"2010221809","pmid":"https://pubmed.ncbi.nlm.nih.gov/6402818"},"language":"en","primary_location":{"id":"doi:10.1126/science.6402818","doi":"https://doi.org/10.1126/science.6402818","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.6402818","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068872608","display_name":"Alfred Nordheim","orcid":"https://orcid.org/0000-0003-4680-0778","observed_orcids":["https://orcid.org/0000-0003-4680-0778"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred Nordheim","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Min Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Min Hao","raw_affiliation_strings":["Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034401273","display_name":"Gerald N. Wogan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald N. Wogan","raw_affiliation_strings":["Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103066840","display_name":"Alexander Rich","orcid":"https://orcid.org/0000-0002-1951-1180","observed_orcids":["https://orcid.org/0000-0002-1951-1180"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Rich","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":2.542,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90067668,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"219","issue":"4591","first_page":"1434","last_page":"1436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aflatoxin-b1","display_name":"aflatoxin B1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/z-dna","display_name":"Z-DNA","score":0.9570000171661377},{"id":"https://openalex.org/keywords/b-dna","display_name":"B-DNA","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dna-conformational-change","display_name":"DNA conformational change","score":0.746999979019165},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.6669999957084656},{"id":"https://openalex.org/keywords/carcinogen-dna-adducts","display_name":"carcinogen-DNA adducts","score":0.6269999742507935},{"id":"https://openalex.org/keywords/dna-binding-inhibition","display_name":"DNA binding inhibition","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C40758303","wikidata":"https://www.wikidata.org/wiki/Q212936","display_name":"Aflatoxin","level":2,"score":0.8813486099243164},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.8316662311553955},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.7408126592636108},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7145466804504395},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.7064561247825623},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6245898604393005},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.587337851524353},{"id":"https://openalex.org/C77122620","wikidata":"https://www.wikidata.org/wiki/Q135758","display_name":"Z-DNA","level":3,"score":0.49155673384666443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4215160012245178},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37463587522506714},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24616503715515137},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.20108374953269958}],"mesh":[{"descriptor_ui":"D000348","descriptor_name":"Aflatoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.6402818","doi":"https://doi.org/10.1126/science.6402818","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.6402818","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:6402818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6402818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1574269421","https://openalex.org/W1964606787","https://openalex.org/W1971481046","https://openalex.org/W1973503110","https://openalex.org/W1990933742","https://openalex.org/W1996201492","https://openalex.org/W2031926845","https://openalex.org/W2036947564","https://openalex.org/W2064478917","https://openalex.org/W2064752311","https://openalex.org/W2075001062","https://openalex.org/W2089351342","https://openalex.org/W2091489838","https://openalex.org/W2096829553","https://openalex.org/W2119526433","https://openalex.org/W2148308569","https://openalex.org/W2168312010"],"related_works":["https://openalex.org/W2007667302","https://openalex.org/W2018869043","https://openalex.org/W2069870792","https://openalex.org/W115074200","https://openalex.org/W2003646772","https://openalex.org/W1964134090","https://openalex.org/W7118946685","https://openalex.org/W2081083186","https://openalex.org/W2334059359","https://openalex.org/W2153249262"],"abstract_inverted_index":{"The":[0],"carcinogen":[1],"aflatoxin":[2,51],"B1":[3],"was":[4],"reacted":[5],"with":[6,50],"a":[7],"polymer":[8,28,59],"of":[9,26,57],"alternating":[10],"deoxyguanine":[11],"and":[12],"deoxycytosine":[13],"residues":[14],"to":[15,39,62],"determine":[16],"the":[17,24,30,40,54],"effect":[18],"that":[19],"adduct":[20],"formation":[21],"has":[22],"on":[23],"conversion":[25,56],"this":[27,58],"from":[29,60],"right-handed":[31],"B-DNA":[32,61],"form":[33,43],"found":[34,44],"at":[35,45,70],"low":[36,72],"salt":[37,47],"concentrations":[38],"left-handed":[41],"Z-DNA":[42],"high":[46],"concentrations.":[48],"Reaction":[49],"strongly":[52],"inhibited":[53],"salt-induced":[55],"Z-DNA.":[63],"This":[64],"inhibition":[65],"could":[66],"be":[67],"detected":[68],"even":[69],"relatively":[71],"binding":[73],"levels.":[74]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}