{"id":"https://openalex.org/W2010220050","doi":"https://doi.org/10.1210/endo-109-3-768","title":"The Fate of [125I]Iodoepidermal Growth Factor in Isolated Hepatocytes: A Quantitative Electron Microscopic Autoradiographic Study*","display_name":"The Fate of [125I]Iodoepidermal Growth Factor in Isolated Hepatocytes: A Quantitative Electron Microscopic Autoradiographic Study*","publication_year":1981,"publication_date":"1981-09-01","ids":{"openalex":"https://openalex.org/W2010220050","doi":"https://doi.org/10.1210/endo-109-3-768","mag":"2010220050","pmid":"https://pubmed.ncbi.nlm.nih.gov/6973464"},"language":"en","primary_location":{"id":"doi:10.1210/endo-109-3-768","doi":"https://doi.org/10.1210/endo-109-3-768","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-109-3-768","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113671278","display_name":"Jean\u2010Louis Carpentier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"JEAN-LOUIS CARPENTIER","raw_affiliation_strings":["Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070064147","display_name":"Phillip G\u00f6rden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"PHILLIP GORDEN","raw_affiliation_strings":["Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062448878","display_name":"Pierre Freychet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"PIERRE FREYCHET","raw_affiliation_strings":["Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000612957","display_name":"Bertrand Canivet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"BERTRAND CANIVET","raw_affiliation_strings":["Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034171652","display_name":"Lelio Orci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"LELIO ORCI","raw_affiliation_strings":["Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland; INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I114457229","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U145 Department of Experimental Medicine (P.F., B.C.) Nice, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institute of Histology and Embryology, University of Geneva School of Medicine (J.L.C., P.G., L.O.) Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.089,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.87085962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"109","issue":"3","first_page":"768","last_page":"775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9070000052452087},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.8889999985694885},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.5249999761581421},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.9198682308197021},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.800082802772522},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6890835762023926},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6282867193222046},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5728580951690674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5512319207191467},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5390260815620422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5302735567092896},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.5180264115333557},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.46692559123039246},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46117863059043884},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4568932056427002},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.44633305072784424},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.42703408002853394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3499964475631714},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3372640609741211},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2868199944496155},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.24245426058769226},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0769391655921936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-109-3-768","doi":"https://doi.org/10.1210/endo-109-3-768","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-109-3-768","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:6973464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6973464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1490154674","https://openalex.org/W1595351294","https://openalex.org/W1606395080","https://openalex.org/W1979075448","https://openalex.org/W1979170193","https://openalex.org/W1982379148","https://openalex.org/W2019382042","https://openalex.org/W2023506714","https://openalex.org/W2029287429","https://openalex.org/W2031380431","https://openalex.org/W2032149507","https://openalex.org/W2037412892","https://openalex.org/W2047671656","https://openalex.org/W2051479937","https://openalex.org/W2058811899","https://openalex.org/W2076907924","https://openalex.org/W2085570743","https://openalex.org/W2093479997","https://openalex.org/W2094635321","https://openalex.org/W2099335992","https://openalex.org/W2100075764","https://openalex.org/W2125648721","https://openalex.org/W2156542247","https://openalex.org/W2164188238","https://openalex.org/W2415130634","https://openalex.org/W2883239271"],"related_works":["https://openalex.org/W2019382042","https://openalex.org/W1979170193","https://openalex.org/W1979075448","https://openalex.org/W2029287429","https://openalex.org/W1980632335","https://openalex.org/W7096672777","https://openalex.org/W2072208718","https://openalex.org/W2155299121","https://openalex.org/W4236817951","https://openalex.org/W2152421249"],"abstract_inverted_index":{"When":[0,32],"[125I]iodoepidermal":[1],"growth":[2,98],"factor":[3,99],"is":[4,38,59,100,118],"incubated":[5],"with":[6,54,72,84],"freshly":[7],"isolated":[8],"rat":[9],"hepatocytes,":[10],"cell-associated":[11,36],"radioactivity":[12,37],"reaches":[13],"apparent":[14],"steady":[15],"state":[16],"by":[17,24,45],"60":[18],"min":[19,26],"at":[20,29,40],"20":[21],"C":[22],"and":[23,58,87],"30":[25],"of":[27,35,43,65,96,122,125],"incubation":[28,44],"37":[30],"C.":[31],"the":[33,50,55,94,107,115,119,123],"distribution":[34],"studied":[39],"different":[41],"times":[42],"quantitative":[46],"electron":[47],"microscopic":[48],"autoradiography,":[49],"ligand":[51,69,108],"initially":[52],"associates":[53,71],"plasma":[56],"membrane":[57],"progressively":[60],"internalized":[61,68],"as":[62],"a":[63],"function":[64],"time.":[66],"The":[67,103],"preferentially":[70],"lysosome-like":[73],"structures.":[74],"Qualitatively,":[75],"these":[76],"events":[77],"are":[78],"similar":[79],"to":[80],"those":[81],"previously":[82],"obtained":[83],"labeled":[85],"insulin":[86],"glucagon":[88],"in":[89],"this":[90],"cell,":[91],"but":[92],"quantitatively,":[93],"internalization":[95],"epidermal":[97],"much":[101],"greater.":[102],"data":[104],"suggest":[105],"that":[106],"or":[109],"its":[110],"specific":[111],"receptor":[112],"rather":[113],"than":[114],"cell":[116],"type":[117],"major":[120],"determinant":[121],"rate":[124],"internalization.":[126]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}