{"id":"https://openalex.org/W2010217031","doi":"https://doi.org/10.1002/pros.2990140103","title":"Semisynthetic anti\u2010lhrh vaccine causing atrophy of the prostate","display_name":"Semisynthetic anti\u2010lhrh vaccine causing atrophy of the prostate","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2010217031","doi":"https://doi.org/10.1002/pros.2990140103","mag":"2010217031","pmid":"https://pubmed.ncbi.nlm.nih.gov/2648346"},"language":"en","primary_location":{"id":"doi:10.1002/pros.2990140103","doi":"https://doi.org/10.1002/pros.2990140103","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.2990140103","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073598181","display_name":"Radhika Jayashankar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Radhika Jayashankar","raw_affiliation_strings":["National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072484994","display_name":"Manas K. Chaudhuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manas K. Chaudhuri","raw_affiliation_strings":["National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111644367","display_name":"Om Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Om Singh","raw_affiliation_strings":["National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111778442","display_name":"Anis Alam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anis Alam","raw_affiliation_strings":["National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110121073","display_name":"Gursaran Parshad Talwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G. P. Talwar","raw_affiliation_strings":["National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, Shaheed Jeet Singh Marg, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073598181"],"corresponding_institution_ids":["https://openalex.org/I4210156726"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":5.3474,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.95485412,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"1","first_page":"3","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luteinizing-hormone-releasing-hormone-analog","display_name":"luteinizing hormone-releasing hormone analogue","score":0.8980000019073486},{"id":"https://openalex.org/keywords/diphtheria-toxoid-conjugate","display_name":"diphtheria toxoid conjugate","score":0.9769999980926514},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/testosterone-decline","display_name":"testosterone decline","score":0.5099999904632568},{"id":"https://openalex.org/keywords/prostatic-atrophy","display_name":"prostate atrophy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/androgen-dependent-prostate-cancer","display_name":"androgen-dependent prostate cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6542303562164307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6527180075645447},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6430749893188477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6070140600204468},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5944243669509888},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5922666192054749},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5178861618041992},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.460593581199646},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4575788378715515},{"id":"https://openalex.org/C2777892665","wikidata":"https://www.wikidata.org/wiki/Q1622678","display_name":"Testicular atrophy","level":2,"score":0.444828063249588},{"id":"https://openalex.org/C2777351567","wikidata":"https://www.wikidata.org/wiki/Q908822","display_name":"Toxoid","level":4,"score":0.4110533893108368},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38201603293418884},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19878694415092468},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18526247143745422},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.14784666895866394}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pros.2990140103","doi":"https://doi.org/10.1002/pros.2990140103","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.2990140103","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:2648346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2648346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306149","display_name":"Rockefeller Foundation","ror":"https://ror.org/03sfkwk85"},{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W622502106","https://openalex.org/W1590058201","https://openalex.org/W1974448196","https://openalex.org/W1986422915","https://openalex.org/W1991618721","https://openalex.org/W1993509602","https://openalex.org/W1995142571","https://openalex.org/W1997662342","https://openalex.org/W1998104267","https://openalex.org/W2012274634","https://openalex.org/W2021314548","https://openalex.org/W2022690114","https://openalex.org/W2028505781","https://openalex.org/W2034271481","https://openalex.org/W2043845246","https://openalex.org/W2065270854","https://openalex.org/W2067101889","https://openalex.org/W2074493374","https://openalex.org/W2079205050","https://openalex.org/W2080580789","https://openalex.org/W2105108209","https://openalex.org/W2414664610","https://openalex.org/W2766914355","https://openalex.org/W4210774194"],"related_works":["https://openalex.org/W2009981796","https://openalex.org/W1974059035","https://openalex.org/W2053915683","https://openalex.org/W2066050494","https://openalex.org/W2032181808","https://openalex.org/W2002296763","https://openalex.org/W1977729471","https://openalex.org/W1500516440","https://openalex.org/W2024825039","https://openalex.org/W2028885969"],"abstract_inverted_index":{"A":[0,56],"modified":[1],"luteinizing":[2],"hormone":[3,5],"releasing":[4],"(LHRH)":[6],"analog":[7],"(D-lys)6":[8],"was":[9,27,86,91],"synthesized":[10],"and":[11,35,82],"linked":[12],"to":[13,31],"epsilon-amino":[14],"caproic":[15],"acid":[16],"at":[17],"the":[18,63,77,92,96,107,113],"6th":[19],"position.":[20],"The":[21],"free":[22],"amino":[23],"group":[24],"thus":[25],"generated":[26],"used":[28],"for":[29],"conjugation":[30],"diphtheria":[32],"toxoid.":[33],"Immunogenicity":[34],"bioefficacy":[36],"studies":[37],"of":[38,80,95,103,109,112],"this":[39,104],"conjugate":[40],"vaccine":[41,105],"were":[42],"carried":[43],"out":[44],"in":[45,59,65,76,106],"rodents.":[46],"All":[47],"immunized":[48],"animals":[49],"produced":[50],"antibodies":[51],"reactive":[52],"with":[53],"native":[54],"LHRH.":[55],"gradual":[57],"decline":[58],"testosterone":[60],"levels":[61],"accompanied":[62],"rise":[64],"anti-LHRH":[66],"titers.":[67],"On":[68],"necropsy,":[69],"after":[70],"10":[71],"weeks,":[72],"a":[73,99],"significant":[74],"reduction":[75],"relative":[78],"weights":[79],"testes":[81],"accessory":[83],"sex":[84],"organs":[85],"noticed.":[87],"Of":[88],"particular":[89],"significance":[90],"marked":[93],"atrophy":[94],"prostate,":[97],"indicating":[98],"possible":[100],"therapeutic":[101],"application":[102],"treatment":[108],"androgen-dependent":[110],"carcinoma":[111],"prostate.":[114]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}