{"id":"https://openalex.org/W2010216792","doi":"https://doi.org/10.1038/nrg2159","title":"Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins","display_name":"Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins","publication_year":2007,"publication_date":"2007-09-04","ids":{"openalex":"https://openalex.org/W2010216792","doi":"https://doi.org/10.1038/nrg2159","mag":"2010216792","pmid":"https://pubmed.ncbi.nlm.nih.gov/17768402"},"language":"en","primary_location":{"id":"doi:10.1038/nrg2159","doi":"https://doi.org/10.1038/nrg2159","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrg2159","pdf_url":null,"source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006226657","display_name":"Weidong Wang","orcid":"https://orcid.org/0000-0002-0658-7928","observed_orcids":["https://orcid.org/0000-0002-0658-7928"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weidong Wang","raw_affiliation_strings":["Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell drive, Baltimore, Maryland 21093, USA. wangw@grc.nia.nih.gov","Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell drive, Baltimore, Maryland 21093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell drive, Baltimore, Maryland 21093, USA. wangw@grc.nia.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell drive, Baltimore, Maryland 21093, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006226657"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":null,"apc_paid":null,"fwci":6.8753,"has_fulltext":false,"cited_by_count":675,"citation_normalized_percentile":{"value":0.9901632,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"8","issue":"10","first_page":"735","last_page":"748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":0.8429999947547913},{"id":"https://openalex.org/keywords/brca-genes","display_name":"BRCA genes","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.925000011920929},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.8880000114440918},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fancj","display_name":"FANCJ","score":0.996999979019165},{"id":"https://openalex.org/keywords/fanci","display_name":"FANCI","score":0.9810000061988831},{"id":"https://openalex.org/keywords/palb2","display_name":"PALB2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brip1","display_name":"BRIP1","score":1.0},{"id":"https://openalex.org/keywords/attenuated-total-reflectance","display_name":"ATR","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bloom-syndrome-protein","display_name":"Bloom syndrome protein","score":0.9300000071525574},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5640000104904175},{"id":"https://openalex.org/keywords/breast-cancer-susceptibility","display_name":"breast cancer susceptibility","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7869362831115723},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6464591026306152},{"id":"https://openalex.org/C2779013463","wikidata":"https://www.wikidata.org/wiki/Q1469646","display_name":"Bloom syndrome","level":5,"score":0.6370102763175964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.631681501865387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6137417554855347},{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.6034426689147949},{"id":"https://openalex.org/C2778993383","wikidata":"https://www.wikidata.org/wiki/Q17927056","display_name":"FANCA","level":5,"score":0.5458858013153076},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.5358290672302246},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.532481849193573},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45743682980537415},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.10392102599143982},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.06781497597694397},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000076164","descriptor_name":"Fanconi Anemia Complementation Group N Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020365","descriptor_name":"RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020365","descriptor_name":"RNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051856","descriptor_name":"Fanconi Anemia Complementation Group Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrg2159","doi":"https://doi.org/10.1038/nrg2159","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrg2159","pdf_url":null,"source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},{"id":"pmid:17768402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17768402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W1495571943","https://openalex.org/W1507694958","https://openalex.org/W1523531555","https://openalex.org/W1593424453","https://openalex.org/W1594730027","https://openalex.org/W1840855988","https://openalex.org/W1961774825","https://openalex.org/W1968943627","https://openalex.org/W1977317997","https://openalex.org/W1978411020","https://openalex.org/W1989800108","https://openalex.org/W1991591616","https://openalex.org/W1991841649","https://openalex.org/W1995625759","https://openalex.org/W1996198025","https://openalex.org/W1997104526","https://openalex.org/W2000017794","https://openalex.org/W2002150942","https://openalex.org/W2003058744","https://openalex.org/W2004769477","https://openalex.org/W2006538713","https://openalex.org/W2008396969","https://openalex.org/W2016061380","https://openalex.org/W2016341210","https://openalex.org/W2020382936","https://openalex.org/W2020983840","https://openalex.org/W2024667285","https://openalex.org/W2025840928","https://openalex.org/W2028311411","https://openalex.org/W2028637581","https://openalex.org/W2029026115","https://openalex.org/W2029164849","https://openalex.org/W2033271892","https://openalex.org/W2034702779","https://openalex.org/W2036295786","https://openalex.org/W2036503229","https://openalex.org/W2037350726","https://openalex.org/W2038936226","https://openalex.org/W2040881136","https://openalex.org/W2042056279","https://openalex.org/W2043411667","https://openalex.org/W2048292104","https://openalex.org/W2051087342","https://openalex.org/W2052483270","https://openalex.org/W2056068841","https://openalex.org/W2057637765","https://openalex.org/W2063860903","https://openalex.org/W2064577894","https://openalex.org/W2065417936","https://openalex.org/W2071782656","https://openalex.org/W2074911481","https://openalex.org/W2077504895","https://openalex.org/W2084310601","https://openalex.org/W2085909080","https://openalex.org/W2087505934","https://openalex.org/W2087967916","https://openalex.org/W2091350790","https://openalex.org/W2092113847","https://openalex.org/W2093398724","https://openalex.org/W2095922028","https://openalex.org/W2096048754","https://openalex.org/W2096815117","https://openalex.org/W2098585738","https://openalex.org/W2098697121","https://openalex.org/W2101161126","https://openalex.org/W2101372024","https://openalex.org/W2102358336","https://openalex.org/W2107610354","https://openalex.org/W2109630092","https://openalex.org/W2110542977","https://openalex.org/W2110817748","https://openalex.org/W2110911775","https://openalex.org/W2112791911","https://openalex.org/W2114907977","https://openalex.org/W2117511932","https://openalex.org/W2118726620","https://openalex.org/W2122003098","https://openalex.org/W2122259228","https://openalex.org/W2127808743","https://openalex.org/W2128700722","https://openalex.org/W2128717251","https://openalex.org/W2130151956","https://openalex.org/W2132641227","https://openalex.org/W2133664283","https://openalex.org/W2134536765","https://openalex.org/W2135077391","https://openalex.org/W2136111611","https://openalex.org/W2137674767","https://openalex.org/W2140036600","https://openalex.org/W2142112049","https://openalex.org/W2142544392","https://openalex.org/W2150152073","https://openalex.org/W2153314251","https://openalex.org/W2154421320","https://openalex.org/W2154856948","https://openalex.org/W2157866186","https://openalex.org/W2159979213","https://openalex.org/W2161854614","https://openalex.org/W2162385336","https://openalex.org/W2163313836","https://openalex.org/W2163599181","https://openalex.org/W2164458581","https://openalex.org/W2166483233","https://openalex.org/W2281048538","https://openalex.org/W2478888756","https://openalex.org/W4302183079"],"related_works":["https://openalex.org/W3173659771","https://openalex.org/W1986096893","https://openalex.org/W2166267427","https://openalex.org/W7096403610","https://openalex.org/W2014623218","https://openalex.org/W2092950132","https://openalex.org/W2478199023","https://openalex.org/W1991841649","https://openalex.org/W2163773782","https://openalex.org/W2169114548"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":42},{"year":2013,"cited_by_count":52},{"year":2012,"cited_by_count":53}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
