{"id":"https://openalex.org/W2010201839","doi":"https://doi.org/10.1016/s1566-2772(00)00006-2","title":"Physiologic roles for the heme oxygenase products carbon monoxide, bilirubin and iron: links to neuroprotection in stroke and Alzheimer's disease","display_name":"Physiologic roles for the heme oxygenase products carbon monoxide, bilirubin and iron: links to neuroprotection in stroke and Alzheimer's disease","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2010201839","doi":"https://doi.org/10.1016/s1566-2772(00)00006-2","mag":"2010201839"},"language":"en","primary_location":{"id":"doi:10.1016/s1566-2772(00)00006-2","doi":"https://doi.org/10.1016/s1566-2772(00)00006-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1566-2772(00)00006-2","pdf_url":null,"source":{"id":"https://openalex.org/S155668084","display_name":"Clinical Neuroscience Research","issn_l":"1566-2772","issn":["1566-2772","1873-779X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030220981","display_name":"David E. Bara\u00f1ano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E Bara\u00f1ano","raw_affiliation_strings":["Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe street, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001458728","display_name":"Sylvain Dor\u00e9","orcid":"https://orcid.org/0000-0003-3771-5109","observed_orcids":["https://orcid.org/0000-0003-3771-5109"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvain Dor\u00e9","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, The John Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA","Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, The John Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113810767","display_name":"Christopher D. Ferris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D Ferris","raw_affiliation_strings":["Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020208893","display_name":"Solomon H. Snyder","orcid":"https://orcid.org/0000-0002-6818-7022","observed_orcids":["https://orcid.org/0000-0002-6818-7022"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Solomon H Snyder","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8093,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68670788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"1-2","first_page":"46","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase","display_name":"heme oxygenase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.8500000238418579},{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.6570000052452087},{"id":"https://openalex.org/keywords/heme-oxygenase-2","display_name":"heme oxygenase-2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7850000262260437},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9340000152587891},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.7760000228881836},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/non-adrenergic-non-cholinergic-neurotransmission","display_name":"non-adrenergic non-cholinergic neurotransmission","score":0.8799999952316284},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7390000224113464},{"id":"https://openalex.org/keywords/endothelial-vasodilation","display_name":"endothelial vasodilation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/iron-efflux","display_name":"iron efflux","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.6629999876022339},{"id":"https://openalex.org/keywords/biliverdin-reductase","display_name":"biliverdin reductase","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8707064390182495},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.7011502385139465},{"id":"https://openalex.org/C2776253728","wikidata":"https://www.wikidata.org/wiki/Q422964","display_name":"Biliverdin","level":5,"score":0.6451083421707153},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.5429484844207764},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5199255347251892},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5130316019058228},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5041114091873169},{"id":"https://openalex.org/C512735826","wikidata":"https://www.wikidata.org/wiki/Q2025","display_name":"Carbon monoxide","level":3,"score":0.49991416931152344},{"id":"https://openalex.org/C2781119925","wikidata":"https://www.wikidata.org/wiki/Q125367","display_name":"Carbon monoxide poisoning","level":3,"score":0.44676434993743896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3895685374736786},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.3732600808143616},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32213813066482544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.267299085855484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19327062368392944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1393345296382904},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.06597769260406494},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.048868387937545776},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1566-2772(00)00006-2","doi":"https://doi.org/10.1016/s1566-2772(00)00006-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1566-2772(00)00006-2","pdf_url":null,"source":{"id":"https://openalex.org/S155668084","display_name":"Clinical Neuroscience Research","issn_l":"1566-2772","issn":["1566-2772","1873-779X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuroscience Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.5799999833106995}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W176337846","https://openalex.org/W1501532586","https://openalex.org/W1538826970","https://openalex.org/W1551093971","https://openalex.org/W1903443535","https://openalex.org/W1966582616","https://openalex.org/W1973482230","https://openalex.org/W1978765308","https://openalex.org/W1979521526","https://openalex.org/W1981165639","https://openalex.org/W1981860537","https://openalex.org/W1988200443","https://openalex.org/W1991723017","https://openalex.org/W2009013636","https://openalex.org/W2030365747","https://openalex.org/W2036725419","https://openalex.org/W2038978204","https://openalex.org/W2056523101","https://openalex.org/W2056584805","https://openalex.org/W2059379142","https://openalex.org/W2060119066","https://openalex.org/W2067714284","https://openalex.org/W2091193879","https://openalex.org/W2093057466","https://openalex.org/W2106097207","https://openalex.org/W2108999152","https://openalex.org/W2131173683","https://openalex.org/W2136262964","https://openalex.org/W2403669450"],"related_works":["https://openalex.org/W176337846","https://openalex.org/W2112107066","https://openalex.org/W1981860537","https://openalex.org/W2145286687","https://openalex.org/W2360649289","https://openalex.org/W2088237849","https://openalex.org/W2030365747","https://openalex.org/W2178860574","https://openalex.org/W1986874510","https://openalex.org/W12057765"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
