{"id":"https://openalex.org/W2010201750","doi":"https://doi.org/10.3402/mehd.v26.26555","title":"Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients","display_name":"Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients","publication_year":2015,"publication_date":"2015-03-09","ids":{"openalex":"https://openalex.org/W2010201750","doi":"https://doi.org/10.3402/mehd.v26.26555","mag":"2010201750","pmid":"https://pubmed.ncbi.nlm.nih.gov/25758371","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4355505"},"language":"en","primary_location":{"id":"doi:10.3402/mehd.v26.26555","doi":"https://doi.org/10.3402/mehd.v26.26555","is_oa":false,"landing_page_url":"https://doi.org/10.3402/mehd.v26.26555","pdf_url":null,"source":{"id":"https://openalex.org/S60092779","display_name":"Microbial Ecology in Health and Disease","issn_l":"0891-060X","issn":["0891-060X","1234-987X","1651-2235"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Ecology in Health & Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4355505","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022461817","display_name":"Daniel T. McDonald","orcid":"https://orcid.org/0000-0003-0876-9060","observed_orcids":["https://orcid.org/0000-0003-0876-9060"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I2802236040","display_name":"University of Colorado System","ror":"https://ror.org/00jc20583","country_code":"US","type":"education","lineage":["https://openalex.org/I2802236040"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel McDonald","raw_affiliation_strings":["BioFrontiers Institute, University of Colorado, Boulder, CO, USA","Department of Computer Science, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioFrontiers Institute, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660","https://openalex.org/I2802236040"]},{"raw_affiliation_string":"Department of Computer Science, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058548310","display_name":"Mady Hornig","orcid":"https://orcid.org/0000-0001-7572-3092","observed_orcids":["https://orcid.org/0000-0001-7572-3092"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mady Hornig","raw_affiliation_strings":["Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, USA","Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086938254","display_name":"Catherine Lozupone","orcid":"https://orcid.org/0000-0003-4786-7202","observed_orcids":["https://orcid.org/0000-0003-4786-7202"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Lozupone","raw_affiliation_strings":["Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087710431","display_name":"Justine W. Debelius","orcid":"https://orcid.org/0000-0002-8605-3546","observed_orcids":["https://orcid.org/0000-0002-8605-3546"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justine Debelius","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO, USA","Department of Computer Science, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Computer Science, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057060580","display_name":"Jack A. Gilbert","orcid":"https://orcid.org/0000-0001-7920-7001","observed_orcids":["https://orcid.org/0000-0001-7920-7001"]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Jack A. Gilbert","raw_affiliation_strings":["College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China; gilbertjack@anl.gov","Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA","Institute for Genomic and Systems Biology, Argonne National Laboratory, Argonne, IL, USA","Marine Biological Laboratory, Woods Hole, MA, USA","University-of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China; gilbertjack@anl.gov","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomic and Systems Biology, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]},{"raw_affiliation_string":"Marine Biological Laboratory, Woods Hole, MA, USA","institution_ids":["https://openalex.org/I1338920048"]},{"raw_affiliation_string":"University-of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033881627","display_name":"Rob D. Knight","orcid":"https://orcid.org/0000-0002-0975-9019","observed_orcids":["https://orcid.org/0000-0002-0975-9019","https://orcid.org/0000-0001-7531-0087"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rob Knight","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO, USA","Department of Computer Science, University of Colorado, Boulder, CO, USA","Howard Hughes Medical Institute, Boulder, CO, USA","Department of Computer Science University of Colorado, Boulder, CO, USA; Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO, USA; Howard Hughes Medical Institute Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Computer Science, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boulder, CO, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Department of Computer Science University of Colorado, Boulder, CO, USA; Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO, USA; Howard Hughes Medical Institute Boulder, CO, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5057060580"],"corresponding_institution_ids":["https://openalex.org/I1282105669","https://openalex.org/I1338920048","https://openalex.org/I40347166","https://openalex.org/I76130692"],"apc_list":{"value":1600,"currency":"EUR","value_usd":1725},"apc_paid":null,"fwci":1.3147,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78930902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"26","issue":"0","first_page":"26555","last_page":"26555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.984000027179718},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9769999980926514},{"id":"https://openalex.org/keywords/microbiome","display_name":"microbiome","score":0.5540000200271606},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.6060000061988831},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.843999981880188},{"id":"https://openalex.org/keywords/longitudinal-study","display_name":"longitudinal study","score":0.6660000085830688},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.7260000109672546},{"id":"https://openalex.org/keywords/microbiome-transfer","display_name":"microbiome transfer","score":0.6959999799728394},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.49799999594688416},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.5490000247955322},{"id":"https://openalex.org/keywords/citizen-science","display_name":"citizen science","score":0.6990000009536743},{"id":"https://openalex.org/keywords/american-gut-project","display_name":"American Gut Project","score":0.9440000057220459},{"id":"https://openalex.org/keywords/large-cohort-studies","display_name":"large cohort studies","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6344798803329468},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.5945963263511658},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.5690588355064392},{"id":"https://openalex.org/C2778391849","wikidata":"https://www.wikidata.org/wiki/Q1079090","display_name":"Neurotypical","level":4,"score":0.5489748120307922},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.5395374298095703},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.5230263471603394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4246193468570709},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4240434765815735},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4173981249332428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3505121171474457},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32464760541915894},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29966169595718384},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.24806252121925354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20041567087173462},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08986806869506836},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3402/mehd.v26.26555","doi":"https://doi.org/10.3402/mehd.v26.26555","is_oa":false,"landing_page_url":"https://doi.org/10.3402/mehd.v26.26555","pdf_url":null,"source":{"id":"https://openalex.org/S60092779","display_name":"Microbial Ecology in Health and Disease","issn_l":"0891-060X","issn":["0891-060X","1234-987X","1651-2235"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Ecology in Health & Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3333625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4355505","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4355505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4355505","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microb Ecol Health Dis","raw_type":"Text"},{"id":"pmid:25758371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25758371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial ecology in health and disease","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1209267","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1209267","pdf_url":"https://www.osti.gov/servlets/purl/1209267","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:f5da68fefa2e416ebf345fef2115b2a8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f5da68fefa2e416ebf345fef2115b2a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Ecology in Health and Disease, Vol 26, Iss 0, Pp 1-9 (2015)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt3c17v41m","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3c17v41m","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial ecology in health and disease, vol 26, iss 0","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3c17v41m","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3c17v41m","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Ecology in Health and Disease, vol 26, iss 0","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3333625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4355505","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G102163711","display_name":null,"funder_award_id":"DE\u2010 AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G262962599","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3751068359","display_name":null,"funder_award_id":"R56 NS086122","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G414170283","display_name":"IGERT:  Interdisciplinary Quantitative Biology Program","funder_award_id":"1144807","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4773474409","display_name":"Infection, fever and immune signatures in an autism birth cohort","funder_award_id":"1r56ns086122-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G513797252","display_name":null,"funder_award_id":"DE-AC02\u201306CH11357","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5607048534","display_name":null,"funder_award_id":"DE-AC02\u201306CH11357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6848031779","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8215692708","display_name":"The Role of Syntrophic Bacteria in Methanogenic Metabolism in the Human Gut","funder_award_id":"K01DK090285","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320310347","display_name":"Emch Foundation","ror":"https://ror.org/035dcj063"},{"id":"https://openalex.org/F4320315019","display_name":"Simons Foundation Autism Research Initiative","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010201750.pdf","grobid_xml":"https://content.openalex.org/works/W2010201750.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W60922589","https://openalex.org/W1576160777","https://openalex.org/W1612925887","https://openalex.org/W1965027165","https://openalex.org/W1966584131","https://openalex.org/W1968105193","https://openalex.org/W1969564659","https://openalex.org/W1970284196","https://openalex.org/W1970406018","https://openalex.org/W1971415551","https://openalex.org/W1972237932","https://openalex.org/W1979091134","https://openalex.org/W1983719006","https://openalex.org/W1986767459","https://openalex.org/W1989401022","https://openalex.org/W1990590570","https://openalex.org/W1993399595","https://openalex.org/W1996014117","https://openalex.org/W1996441448","https://openalex.org/W1999906527","https://openalex.org/W2001938165","https://openalex.org/W2003193619","https://openalex.org/W2005365566","https://openalex.org/W2011447176","https://openalex.org/W2012953866","https://openalex.org/W2013700693","https://openalex.org/W2021408544","https://openalex.org/W2023506796","https://openalex.org/W2025487699","https://openalex.org/W2025589766","https://openalex.org/W2033571021","https://openalex.org/W2043442946","https://openalex.org/W2044149977","https://openalex.org/W2047798386","https://openalex.org/W2048359070","https://openalex.org/W2051567523","https://openalex.org/W2053039168","https://openalex.org/W2054927285","https://openalex.org/W2063856799","https://openalex.org/W2064196550","https://openalex.org/W2064522355","https://openalex.org/W2065443051","https://openalex.org/W2068809175","https://openalex.org/W2069098110","https://openalex.org/W2072909309","https://openalex.org/W2073810410","https://openalex.org/W2076889101","https://openalex.org/W2080528636","https://openalex.org/W2085284704","https://openalex.org/W2087373760","https://openalex.org/W2093715975","https://openalex.org/W2094708275","https://openalex.org/W2094792989","https://openalex.org/W2096139589","https://openalex.org/W2097478615","https://openalex.org/W2098747186","https://openalex.org/W2099957728","https://openalex.org/W2103088074","https://openalex.org/W2103294794","https://openalex.org/W2106399600","https://openalex.org/W2110300022","https://openalex.org/W2117029190","https://openalex.org/W2122707054","https://openalex.org/W2124555526","https://openalex.org/W2125531274","https://openalex.org/W2126218947","https://openalex.org/W2128117277","https://openalex.org/W2128769815","https://openalex.org/W2129917444","https://openalex.org/W2132929849","https://openalex.org/W2136552678","https://openalex.org/W2139884694","https://openalex.org/W2143102114","https://openalex.org/W2143777796","https://openalex.org/W2149174165","https://openalex.org/W2149785057","https://openalex.org/W2151670857","https://openalex.org/W2153537282","https://openalex.org/W2154679373","https://openalex.org/W2155825126","https://openalex.org/W2156962544","https://openalex.org/W2157159562","https://openalex.org/W2158877339","https://openalex.org/W2162088497","https://openalex.org/W2164685446","https://openalex.org/W2166171121","https://openalex.org/W2166562121","https://openalex.org/W2167123129","https://openalex.org/W2168887663","https://openalex.org/W2168900565","https://openalex.org/W3107560836","https://openalex.org/W3133889722","https://openalex.org/W4247708434"],"related_works":["https://openalex.org/W4304196162","https://openalex.org/W3001022066","https://openalex.org/W2915174336","https://openalex.org/W4406135435","https://openalex.org/W4416271118","https://openalex.org/W2952173081","https://openalex.org/W3161168818","https://openalex.org/W4382918636","https://openalex.org/W6991325325","https://openalex.org/W2009724429"],"abstract_inverted_index":{"Differences":[0],"in":[1,23,48,78,86,144,169,175],"the":[2,24,73,79,102,132,170,176],"gut":[3],"microbiota":[4],"have":[5,108,136],"been":[6,31,137],"reported":[7],"between":[8],"individuals":[9],"with":[10,126,148],"autism":[11],"spectrum":[12],"disorders":[13],"(ASD)":[14],"and":[15,88,147,151,154,166],"neurotypical":[16],"controls,":[17],"although":[18],"direct":[19],"evidence":[20],"that":[21,43,57,69],"changes":[22],"microbiome":[25,80,142],"contribute":[26],"to":[27,33,111,160],"causing":[28],"ASD":[29],"has":[30],"scarce":[32],"date.":[34],"Here":[35],"we":[36],"summarize":[37],"some":[38,71],"considerations":[39],"of":[40,72,75,104,128,163,172],"experimental":[41],"design":[42],"can":[44,58],"help":[45],"untangle":[46],"causality":[47],"this":[49],"complex":[50],"system.":[51],"In":[52],"particular,":[53],"large":[54],"cross-sectional":[55],"studies":[56,68,89,125,168],"factor":[59],"out":[60],"important":[61],"variables":[62],"such":[63,130],"as":[64,131],"diet,":[65],"prospective":[66],"longitudinal":[67],"remove":[70],"influence":[74],"interpersonal":[76],"variation":[77],"(which":[81],"is":[82,115],"generally":[83],"high,":[84],"especially":[85,98,174],"children),":[87],"transferring":[90],"microbial":[91],"communities":[92],"into":[93],"germ-free":[94],"mice":[95],"may":[96,155],"be":[97],"useful.":[99],"Controlling":[100],"for":[101],"effects":[103,143],"technical":[105],"variables,":[106],"which":[107],"complicated":[109],"efforts":[110],"combine":[112],"existing":[113],"studies,":[114],"critical":[116],"when":[117],"biological":[118],"effect":[119],"sizes":[120],"are":[121],"small.":[122],"Large":[123],"citizen-science":[124],"thousands":[127],"participants":[129],"American":[133],"Gut":[134],"Project":[135],"effective":[138],"at":[139],"uncovering":[140],"subtle":[141],"self-collected":[145],"samples":[146],"self-reported":[149],"diet":[150],"behavior":[152],"data,":[153],"provide":[156],"a":[157],"useful":[158],"complement":[159],"other":[161],"types":[162],"traditionally":[164],"funded":[165],"conducted":[167],"case":[171],"ASD,":[173],"hypothesis":[177],"generation":[178],"phase.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}