{"id":"https://openalex.org/W2010187130","doi":"https://doi.org/10.1159/000085559","title":"Molecular Classification and Pathogenesis of Eosinophilic Disorders: 2005 Update","display_name":"Molecular Classification and Pathogenesis of Eosinophilic Disorders: 2005 Update","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2010187130","doi":"https://doi.org/10.1159/000085559","mag":"2010187130","pmid":"https://pubmed.ncbi.nlm.nih.gov/15995322"},"language":"en","primary_location":{"id":"doi:10.1159/000085559","doi":"https://doi.org/10.1159/000085559","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000085559","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065621786","display_name":"Jason R. Gotlib","orcid":"https://orcid.org/0000-0001-8253-6156","observed_orcids":["https://orcid.org/0000-0001-8253-6156"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason Gotlib","raw_affiliation_strings":["Stanford Cancer Center, 875 Blake Wilbur Drive, Rm. 2327B, Stanford, CA 94305-5821, USA. jason.gotlib@stanford.edu","Stanford Cancer Center, 875 Blake Wilbur Drive, Rm. 2327B, Stanford, CA 94305-5821, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cancer Center, 875 Blake Wilbur Drive, Rm. 2327B, Stanford, CA 94305-5821, USA. jason.gotlib@stanford.edu","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Cancer Center, 875 Blake Wilbur Drive, Rm. 2327B, Stanford, CA 94305-5821, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065621786"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":2.3454,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.9,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"114","issue":"1","first_page":"7","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eosinophilic-disorders","display_name":"eosinophilic disorders","score":0.9020000100135803},{"id":"https://openalex.org/keywords/idiopathic-hypereosinophilic-syndrome","display_name":"idiopathic hypereosinophilic syndrome","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hypereosinophilia","display_name":"hypereosinophilia","score":0.7979999780654907},{"id":"https://openalex.org/keywords/molecular-classification","display_name":"molecular classification","score":0.722000002861023},{"id":"https://openalex.org/keywords/pdgfra-rearrangement","display_name":"PDGFRA rearrangement","score":0.7720000147819519},{"id":"https://openalex.org/keywords/pdgfrb-rearrangement","display_name":"PDGFRB rearrangement","score":0.7919999957084656},{"id":"https://openalex.org/keywords/fip1l1-pdgfra-fusion","display_name":"FIP1L1-PDGFRA fusion","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chronic-myelomonocytic-leukemia","display_name":"chronic myelomonocytic leukemia","score":0.781000018119812},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.8140000104904175},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.800000011920929},{"id":"https://openalex.org/keywords/systemic-mast-cell-disease","display_name":"systemic mast cell disease","score":0.9190000295639038},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.7940000295639038},{"id":"https://openalex.org/keywords/clonal-eosinophilia","display_name":"clonal eosinophilia","score":0.7599999904632568},{"id":"https://openalex.org/keywords/8p11-myeloproliferative-syndrome","display_name":"8p11 myeloproliferative syndrome","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2777621362","wikidata":"https://www.wikidata.org/wiki/Q2551272","display_name":"Hypereosinophilic syndrome","level":3,"score":0.7858494520187378},{"id":"https://openalex.org/C2779084869","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Hypereosinophilia","level":3,"score":0.7350190877914429},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.6391634941101074},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5557406544685364},{"id":"https://openalex.org/C2910274570","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative Disorders","level":2,"score":0.5270481705665588},{"id":"https://openalex.org/C2777832160","wikidata":"https://www.wikidata.org/wiki/Q3306175","display_name":"Mepolizumab","level":4,"score":0.5139951109886169},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.5091401934623718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43171170353889465},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.4282684326171875},{"id":"https://openalex.org/C74092355","wikidata":"https://www.wikidata.org/wiki/Q1056943","display_name":"Molecular pathology","level":3,"score":0.41794389486312866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38798195123672485},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3270845413208008},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2945218086242676},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1395222544670105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09334757924079895},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015477","descriptor_name":"Leukemia, Myelomonocytic, Chronic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D015477","descriptor_name":"Leukemia, Myelomonocytic, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015477","descriptor_name":"Leukemia, Myelomonocytic, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020797","descriptor_name":"Receptor, Platelet-Derived Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034721","descriptor_name":"Mastocytosis, Systemic","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D034721","descriptor_name":"Mastocytosis, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034721","descriptor_name":"Mastocytosis, Systemic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D039221","descriptor_name":"mRNA Cleavage and Polyadenylation Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000085559","doi":"https://doi.org/10.1159/000085559","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000085559","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:15995322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15995322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":206,"referenced_works":["https://openalex.org/W11727989","https://openalex.org/W15222133","https://openalex.org/W27937304","https://openalex.org/W39467412","https://openalex.org/W60396789","https://openalex.org/W108038632","https://openalex.org/W135722041","https://openalex.org/W168510332","https://openalex.org/W194107821","https://openalex.org/W1483090589","https://openalex.org/W1523217489","https://openalex.org/W1527623537","https://openalex.org/W1554558913","https://openalex.org/W1559197668","https://openalex.org/W1571014830","https://openalex.org/W1575487317","https://openalex.org/W1663457857","https://openalex.org/W1731209109","https://openalex.org/W1765926397","https://openalex.org/W1963557114","https://openalex.org/W1963846089","https://openalex.org/W1964822816","https://openalex.org/W1967330066","https://openalex.org/W1967818209","https://openalex.org/W1967869337","https://openalex.org/W1967871761","https://openalex.org/W1968147012","https://openalex.org/W1968602572","https://openalex.org/W1969171633","https://openalex.org/W1971855003","https://openalex.org/W1972044244","https://openalex.org/W1972144397","https://openalex.org/W1973378655","https://openalex.org/W1975646137","https://openalex.org/W1977394892","https://openalex.org/W1977479933","https://openalex.org/W1978330466","https://openalex.org/W1980746107","https://openalex.org/W1982659189","https://openalex.org/W1985479729","https://openalex.org/W1986232164","https://openalex.org/W1987610476","https://openalex.org/W1987937570","https://openalex.org/W1991632332","https://openalex.org/W1991763093","https://openalex.org/W1991883616","https://openalex.org/W1992089349","https://openalex.org/W1994171871","https://openalex.org/W1995038616","https://openalex.org/W1996188067","https://openalex.org/W1998598760","https://openalex.org/W2000893535","https://openalex.org/W2001426718","https://openalex.org/W2001737705","https://openalex.org/W2002209196","https://openalex.org/W2002286694","https://openalex.org/W2002994095","https://openalex.org/W2003269232","https://openalex.org/W2004258424","https://openalex.org/W2006432362","https://openalex.org/W2006882007","https://openalex.org/W2007021244","https://openalex.org/W2007035402","https://openalex.org/W2008109029","https://openalex.org/W2009075932","https://openalex.org/W2009668570","https://openalex.org/W2009685139","https://openalex.org/W2012460154","https://openalex.org/W2012952884","https://openalex.org/W2013435298","https://openalex.org/W2016126727","https://openalex.org/W2016396075","https://openalex.org/W2016560442","https://openalex.org/W2016826417","https://openalex.org/W2017095962","https://openalex.org/W2018162530","https://openalex.org/W2018633679","https://openalex.org/W2019070364","https://openalex.org/W2019186253","https://openalex.org/W2019275979","https://openalex.org/W2019410619","https://openalex.org/W2019952415","https://openalex.org/W2020341107","https://openalex.org/W2020673819","https://openalex.org/W2024250445","https://openalex.org/W2025690484","https://openalex.org/W2027684265","https://openalex.org/W2027973770","https://openalex.org/W2028440681","https://openalex.org/W2028953182","https://openalex.org/W2031423508","https://openalex.org/W2032742505","https://openalex.org/W2033853336","https://openalex.org/W2034486606","https://openalex.org/W2034571663","https://openalex.org/W2035008903","https://openalex.org/W2036047439","https://openalex.org/W2036180570","https://openalex.org/W2036369565","https://openalex.org/W2037558459","https://openalex.org/W2043314696","https://openalex.org/W2043691024","https://openalex.org/W2044742054","https://openalex.org/W2044820954","https://openalex.org/W2046665593","https://openalex.org/W2046779758","https://openalex.org/W2048785084","https://openalex.org/W2050363606","https://openalex.org/W2054823284","https://openalex.org/W2057383356","https://openalex.org/W2058240442","https://openalex.org/W2060633842","https://openalex.org/W2061736216","https://openalex.org/W2064244980","https://openalex.org/W2064698668","https://openalex.org/W2065112197","https://openalex.org/W2065267909","https://openalex.org/W2066913808","https://openalex.org/W2067684423","https://openalex.org/W2069578188","https://openalex.org/W2071040646","https://openalex.org/W2074644169","https://openalex.org/W2075428599","https://openalex.org/W2076569573","https://openalex.org/W2077187679","https://openalex.org/W2078398386","https://openalex.org/W2079165540","https://openalex.org/W2079704410","https://openalex.org/W2080686114","https://openalex.org/W2081206447","https://openalex.org/W2082291978","https://openalex.org/W2083186952","https://openalex.org/W2083373602","https://openalex.org/W2085573901","https://openalex.org/W2085801059","https://openalex.org/W2089289269","https://openalex.org/W2090045594","https://openalex.org/W2090173484","https://openalex.org/W2090239473","https://openalex.org/W2096180091","https://openalex.org/W2101035491","https://openalex.org/W2110121929","https://openalex.org/W2111914345","https://openalex.org/W2112571856","https://openalex.org/W2121379779","https://openalex.org/W2126524003","https://openalex.org/W2134085362","https://openalex.org/W2134391743","https://openalex.org/W2140626630","https://openalex.org/W2141949848","https://openalex.org/W2142161829","https://openalex.org/W2144541148","https://openalex.org/W2144997552","https://openalex.org/W2145057311","https://openalex.org/W2148775668","https://openalex.org/W2149442576","https://openalex.org/W2151222524","https://openalex.org/W2154317310","https://openalex.org/W2158674200","https://openalex.org/W2161037099","https://openalex.org/W2161167886","https://openalex.org/W2167008792","https://openalex.org/W2169084046","https://openalex.org/W2171620774","https://openalex.org/W2172112558","https://openalex.org/W2184526824","https://openalex.org/W2210873565","https://openalex.org/W2242673443","https://openalex.org/W2253291642","https://openalex.org/W2259285281","https://openalex.org/W2268842808","https://openalex.org/W2280063724","https://openalex.org/W2281850830","https://openalex.org/W2286734053","https://openalex.org/W2289335918","https://openalex.org/W2306041162","https://openalex.org/W2317274197","https://openalex.org/W2328556759","https://openalex.org/W2330754503","https://openalex.org/W2332884773","https://openalex.org/W2335061116","https://openalex.org/W2342251757","https://openalex.org/W2378389557","https://openalex.org/W2401245772","https://openalex.org/W2408425666","https://openalex.org/W2411900611","https://openalex.org/W2412199362","https://openalex.org/W2467654857","https://openalex.org/W2473792341","https://openalex.org/W2549895610","https://openalex.org/W2553781629","https://openalex.org/W2554239635","https://openalex.org/W2557810549","https://openalex.org/W2562458087","https://openalex.org/W2564229618","https://openalex.org/W2564953413","https://openalex.org/W2568035378","https://openalex.org/W2580809237","https://openalex.org/W2586939958","https://openalex.org/W2606488622","https://openalex.org/W2735106437","https://openalex.org/W2980000188","https://openalex.org/W2981221186","https://openalex.org/W3023846844","https://openalex.org/W3114112552","https://openalex.org/W4293245940"],"related_works":["https://openalex.org/W2009551392","https://openalex.org/W2051208219","https://openalex.org/W2063233817","https://openalex.org/W2094716680","https://openalex.org/W1995016923","https://openalex.org/W2003269232","https://openalex.org/W2085402944","https://openalex.org/W2960200384","https://openalex.org/W2021563625","https://openalex.org/W2072982356"],"abstract_inverted_index":{"Use":[0],"of":[1,13,15,19,30,47,67,82,109,124,142,172,229,232,249],"the":[2,16,24,28,45,64,143,184,197,201,210,220,226,239,241],"term":[3],"\"idiopathic":[4],"hypereosinophilic":[5,217],"syndrome":[6],"(HES)\"":[7],"has":[8,32,38,162,180,237],"highlighted":[9],"our":[10],"basic":[11],"lack":[12],"understanding":[14],"molecular":[17,50,85,202,227],"pathophysiology":[18],"eosinophilic":[20,77,127,250],"disorders.":[21,251],"However,":[22],"over":[23],"last":[25],"10":[26],"years,":[27],"study":[29],"hypereosinophilia":[31],"enjoyed":[33],"a":[34,121,230,245],"revival.":[35],"This":[36],"interest":[37],"been":[39],"rekindled":[40],"by":[41,192],"two":[42],"factors:":[43],"(1)":[44],"development":[46],"increasingly":[48],"sophisticated":[49],"biology":[51],"techniques":[52],"that":[53],"have":[54,87],"unmasked":[55],"recurrent":[56,84],"genetic":[57],"abnormalities":[58,86],"linked":[59],"to":[60,75,216],"eosinophilia,":[61],"and":[62,115,209,212],"(2)":[63],"successful":[65],"application":[66],"targeted":[68],"therapy":[69],"with":[70,126,152,157],"agents":[71],"such":[72],"as":[73,166],"imatinib":[74],"treat":[76],"diseases.":[78],"To":[79],"date,":[80],"most":[81],"these":[83,106,164,206],"resulted":[88],"in":[89,148,183,205,224],"constitutively":[90],"activated":[91],"fusion":[92,147,178],"tyrosine":[93],"kinases":[94],"whose":[95],"phenotypic":[96],"consequence":[97],"is":[98,199],"an":[99],"eosinophilia-associated":[100],"myeloid":[101],"disorder.":[102],"Most":[103],"notable":[104],"among":[105],"are":[107,189],"rearrangements":[108],"platelet-derived":[110],"growth":[111,174],"factor":[112,175],"receptors":[113],"alpha":[114],"beta":[116],"(PDGFRalpha,":[117],"PDGFRbeta),":[118],"which":[119,188],"define":[120],"small":[122],"subset":[123],"patients":[125,151],"chronic":[128,138],"myeloproliferative":[129,186],"disorders":[130],"(MPDs)":[131],"and/or":[132],"overlap":[133],"myelodysplastic":[134],"syndrome/MPD":[135],"syndromes,":[136,187,218],"including":[137,219],"myelomonocytic":[139],"leukemia.":[140],"Discovery":[141],"cryptic":[144],"FIP1L1-PDGFRA":[145],"gene":[146],"cytogenetically":[149],"normal":[150],"systemic":[153],"mast":[154],"cell":[155],"disease":[156],"eosinophilia":[158],"or":[159],"idiopathic":[160],"HES":[161],"redefined":[163],"diseases":[165,236],"clonal":[167],"eosinophilias.":[168],"A":[169],"growing":[170],"list":[171],"fibroblast":[173],"receptor":[176],"1":[177],"partners":[179],"similarly":[181],"emerged":[182],"8p11":[185],"often":[190],"characterized":[191],"elevated":[193],"eosinophil":[194],"counts.":[195],"Herein":[196],"focus":[198],"on":[200],"gains":[203],"made":[204],"MPD-type":[207],"eosinophilias,":[208],"classification":[211,247],"clinicopathological":[213],"issues":[214],"related":[215],"lymphocyte":[221],"variant.":[222],"Success":[223],"establishing":[225,244],"basis":[228],"group":[231],"once":[233],"seemingly":[234],"heterogeneous":[235],"now":[238],"laid":[240],"foundation":[242],"for":[243],"semi-molecular":[246],"scheme":[248]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}