{"id":"https://openalex.org/W2010170529","doi":"https://doi.org/10.1074/jbc.m800104200","title":"T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor \u03b3 Binding Properties","display_name":"T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor \u03b3 Binding Properties","publication_year":2008,"publication_date":"2008-02-09","ids":{"openalex":"https://openalex.org/W2010170529","doi":"https://doi.org/10.1074/jbc.m800104200","mag":"2010170529","pmid":"https://pubmed.ncbi.nlm.nih.gov/18263587"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m800104200","doi":"https://doi.org/10.1074/jbc.m800104200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m800104200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m800104200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100421612","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-7134-5685","observed_orcids":["https://orcid.org/0000-0002-7134-5685"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yang Li","raw_affiliation_strings":["Amgen Inc., South San Francisco, CA 94080, USA. yangl@amgen.com","Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, CA 94080, USA. yangl@amgen.com","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120390796","display_name":"Zhulun Wang","orcid":"https://orcid.org/0000-0002-1815-6391","observed_orcids":["https://orcid.org/0000-0002-1815-6391"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhulun Wang","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004326764","display_name":"Noboru Furukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108598","display_name":"Japan Tobacco (Japan)","ror":"https://ror.org/01xdq1k91","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210108598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru Furukawa","raw_affiliation_strings":["Japan Tobacco, Tokyo 105\u20138422, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Tobacco, Tokyo 105\u20138422, Japan","institution_ids":["https://openalex.org/I4210108598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048686008","display_name":"Patrick Escaron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Escaron","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008884508","display_name":"Jennifer Weiszmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Weiszmann","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gary Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Lee","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058782795","display_name":"Michelle Lindstr\u00f6m","orcid":"https://orcid.org/0000-0002-6526-7051","observed_orcids":["https://orcid.org/0000-0002-6526-7051"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Lindstrom","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611766","display_name":"Jinsong Liu","orcid":"https://orcid.org/0000-0003-2317-0558","observed_orcids":["https://orcid.org/0000-0003-2317-0558","https://orcid.org/0000-0002-8982-6719"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinsong Liu","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321212","display_name":"Xiaohong Liu","orcid":"https://orcid.org/0000-0003-4795-3039","observed_orcids":["https://orcid.org/0000-0003-4795-3039"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohong Liu","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000364641","display_name":"Haoda Xu","orcid":"https://orcid.org/0000-0002-5995-316X","observed_orcids":["https://orcid.org/0000-0002-5995-316X"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haoda Xu","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080468748","display_name":"Olga V. Plotnikova","orcid":"https://orcid.org/0000-0002-2513-7287","observed_orcids":["https://orcid.org/0000-0002-2513-7287"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Plotnikova","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vidya Prasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidya Prasad","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019210873","display_name":"Nigel P.C. Walker","orcid":"https://orcid.org/0009-0002-5838-8311","observed_orcids":["https://orcid.org/0009-0002-5838-8311"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigel Walker","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028525734","display_name":"R. Marc Learned","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Marc Learned","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100711013","display_name":"Jinlong Chen","orcid":"https://orcid.org/0000-0002-0742-651X","observed_orcids":["https://orcid.org/0000-0002-0742-651X"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin-Long Chen","raw_affiliation_strings":["Amgen Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I1320553840"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100421612"],"corresponding_institution_ids":["https://openalex.org/I1320553840"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.4656,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.88859976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"283","issue":"14","first_page":"9168","last_page":"9176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ppargamma-ligands","display_name":"PPAR\u03b3 ligands","score":0.6880000233650208},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.8629999756813049},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8579999804496765},{"id":"https://openalex.org/keywords/binding-pocket","display_name":"binding pocket","score":0.7200000286102295},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/kk-ay-mice","display_name":"KK-Ay mice","score":0.7950000166893005},{"id":"https://openalex.org/keywords/x-ray-crystallography","display_name":"X-ray crystallography","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.9344149827957153},{"id":"https://openalex.org/C2776923340","wikidata":"https://www.wikidata.org/wiki/Q1393556","display_name":"Thiazolidinedione","level":4,"score":0.8266372084617615},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6988591551780701},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6152673363685608},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5810997486114502},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5760396718978882},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.5439758896827698},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5389540791511536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5226337909698486},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5022666454315186},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4636133313179016},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4500633776187897},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.42623552680015564},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3920553922653198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3806415796279907},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36554181575775146},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36507439613342285},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36329054832458496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3567131757736206},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3001290559768677},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.19722118973731995},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1876460313796997},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.16653966903686523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06531494855880737},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06082305312156677}],"mesh":[{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096926","descriptor_name":"Benzenesulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m800104200","doi":"https://doi.org/10.1074/jbc.m800104200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m800104200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:18263587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18263587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m800104200","doi":"https://doi.org/10.1074/jbc.m800104200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m800104200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1488559297","https://openalex.org/W1527649416","https://openalex.org/W1527827101","https://openalex.org/W1531166004","https://openalex.org/W1539796472","https://openalex.org/W1936322262","https://openalex.org/W1969437387","https://openalex.org/W1995017064","https://openalex.org/W2001419494","https://openalex.org/W2001641653","https://openalex.org/W2005674716","https://openalex.org/W2013425055","https://openalex.org/W2020175961","https://openalex.org/W2029177106","https://openalex.org/W2046833545","https://openalex.org/W2047591801","https://openalex.org/W2058406367","https://openalex.org/W2061357909","https://openalex.org/W2100265114","https://openalex.org/W2101460040","https://openalex.org/W2103487819","https://openalex.org/W2107117895","https://openalex.org/W2113456624","https://openalex.org/W2115414014","https://openalex.org/W2143808884","https://openalex.org/W2147596285","https://openalex.org/W2156805509","https://openalex.org/W2159083249","https://openalex.org/W2163810943","https://openalex.org/W2169224393","https://openalex.org/W2178920245","https://openalex.org/W2605614532","https://openalex.org/W2916271329"],"related_works":["https://openalex.org/W1811830477","https://openalex.org/W2381159291","https://openalex.org/W2009733869","https://openalex.org/W2299772080","https://openalex.org/W90468220","https://openalex.org/W2581595079","https://openalex.org/W2023375634","https://openalex.org/W2055409225","https://openalex.org/W2159083249","https://openalex.org/W2064326876"],"abstract_inverted_index":{"The":[0,110],"nuclear":[1],"hormone":[2],"receptor":[3,6,71,131,230],"peroxisome":[4],"proliferator-activated":[5],"gamma":[7],"(PPARgamma)":[8],"plays":[9],"central":[10],"roles":[11],"in":[12,126,133,152,156,173],"adipogenesis":[13],"and":[14,17,91,128,143,180,225],"glucose":[15,212],"homeostasis":[16],"is":[18,40],"the":[19,23,43,61,70,95,150,174,199,219,229,244,259],"molecular":[20],"target":[21],"for":[22,149,269,288],"thiazolidinedione":[24],"(TZD)":[25],"class":[26,272],"of":[27,31,45,69,98,120,176,183,228,238,246,258,273,282,290],"antidiabetic":[28],"drugs.":[29],"Activation":[30],"PPARgamma":[32,56,99,125,274],"by":[33,42,115,203],"TZDs":[34],"improves":[35],"insulin":[36,171,247],"sensitivity;":[37],"however,":[38],"this":[39],"accompanied":[41],"induction":[44],"several":[46],"undesirable":[47],"side":[48,200],"effects.":[49],"We":[50,137,261],"have":[51,88],"identified":[52],"a":[53,236,267,270],"novel":[54,151,271],"synthetic":[55],"ligand,":[57],"T2384,":[58],"to":[59,164,197,243],"explore":[60],"biological":[62,240],"activities":[63,145],"associated":[64,254],"with":[65,94,124,160,185,192,218,255],"occupying":[66],"different":[67,111],"regions":[68,227],"ligand-binding":[72,96,231],"pocket.":[73],"X-ray":[74],"crystallography":[75],"studies":[76],"revealed":[77],"that":[78,104,139,221,263,278],"T2384":[79,116,168,194,264],"can":[80],"adopt":[81],"two":[82],"distinct":[83,106,118],"binding":[84,112],"modes,":[85],"which":[86],"we":[87],"termed":[89],"\"U\"":[90],"\"S\",":[92],"interacting":[93],"pocket":[97,232],"primarily":[100],"via":[101],"hydrophobic":[102],"contacts":[103],"are":[105,216],"from":[107],"full":[108,256],"agonists.":[109],"modes":[113],"occupied":[114],"induced":[117,202],"patterns":[119],"coregulatory":[121],"protein":[122],"interaction":[123],"vitro":[127],"displayed":[129],"unique":[130,141],"function":[132],"cell-based":[134],"activity":[135],"assays.":[136],"speculate":[138],"these":[140,283],"biochemical":[142],"cellular":[144],"may":[146,265],"be":[147,286],"responsible":[148],"vivo":[153],"profile":[154],"observed":[155],"animals":[157],"treated":[158],"systemically":[159],"T2384.":[161],"When":[162],"administered":[163],"diabetic":[165],"KKAy":[166],"mice,":[167],"rapidly":[169],"improved":[170],"sensitivity":[172],"absence":[175],"weight":[177],"gain,":[178],"hemodilution,":[179],"anemia":[181],"characteristics":[182],"treatment":[184,205,289],"rosiglitazone":[186,204],"(a":[187],"TZD).":[188],"Moreover,":[189],"upon":[190],"coadministration":[191],"rosiglitazone,":[193],"was":[195],"able":[196],"antagonize":[198],"effects":[201,210],"alone":[206],"while":[207],"retaining":[208],"robust":[209],"on":[211],"disposal.":[213],"These":[214],"results":[215],"consistent":[217],"hypothesis":[220],"interactions":[222],"between":[223],"ligands":[224],"specific":[226],"might":[233],"selectively":[234],"trigger":[235],"subset":[237],"receptor-mediated":[239],"responses":[241,253],"leading":[242],"improvement":[245],"sensitivity,":[248],"without":[249],"eliciting":[250],"less":[251],"desirable":[252],"activation":[257],"receptor.":[260],"suggest":[262],"represent":[266],"prototype":[268],"ligand":[275],"and,":[276],"furthermore,":[277],"molecules":[279],"sharing":[280],"some":[281],"properties":[284],"would":[285],"useful":[287],"type":[291],"2":[292],"diabetes.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}