{"id":"https://openalex.org/W2010163603","doi":"https://doi.org/10.1198/sbr.2011.10013","title":"Time to All-Cause Treatment Discontinuation as the Primary Outcome in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Study","display_name":"Time to All-Cause Treatment Discontinuation as the Primary Outcome in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Study","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W2010163603","doi":"https://doi.org/10.1198/sbr.2011.10013","mag":"2010163603","pmid":"https://pubmed.ncbi.nlm.nih.gov/31031886","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6482974"},"language":"en","primary_location":{"id":"doi:10.1198/sbr.2011.10013","doi":"https://doi.org/10.1198/sbr.2011.10013","is_oa":false,"landing_page_url":"https://doi.org/10.1198/sbr.2011.10013","pdf_url":null,"source":{"id":"https://openalex.org/S104563881","display_name":"Statistics in Biopharmaceutical Research","issn_l":"1946-6315","issn":["1946-6315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Biopharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6482974","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041019143","display_name":"Sonia Thomas","orcid":"https://orcid.org/0000-0003-1362-5627","observed_orcids":["https://orcid.org/0000-0003-1362-5627"]},"institutions":[{"id":"https://openalex.org/I28927889","display_name":"IQVIA (United Kingdom)","ror":"https://ror.org/040g76k92","country_code":"GB","type":"company","lineage":["https://openalex.org/I28927889","https://openalex.org/I4210108991"]},{"id":"https://openalex.org/I4210096889","display_name":"IQVIA (India)","ror":"https://ror.org/00szk3r18","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210096889","https://openalex.org/I4210108991"]},{"id":"https://openalex.org/I4210108991","display_name":"IQVIA (United States)","ror":"https://ror.org/01mk44223","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108991"]}],"countries":["GB","IN","US"],"is_corresponding":false,"raw_author_name":"Sonia M. Davis","raw_affiliation_strings":["Quintiles, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quintiles, Inc","institution_ids":["https://openalex.org/I28927889","https://openalex.org/I4210096889","https://openalex.org/I4210108991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023756758","display_name":"T. Scott Stroup","orcid":"https://orcid.org/0000-0002-3123-0672","observed_orcids":["https://orcid.org/0000-0002-3123-0672"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Scott Stroup","raw_affiliation_strings":["Columbia University, Department of Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, Department of Psychiatry","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108081836","display_name":"Gary G. Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary G. Koch","raw_affiliation_strings":["University of North Carolina, Department of Biostatistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Department of Biostatistics","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109940472","display_name":"CLARENCE E. DAVIS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clarence E. Davis","raw_affiliation_strings":["University of North Carolina, Department of Biostatistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Department of Biostatistics","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027752754","display_name":"Robert Alan Rosenheck","orcid":"https://orcid.org/0000-0003-4314-4592","observed_orcids":["https://orcid.org/0000-0003-4314-4592"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Rosenheck","raw_affiliation_strings":["Yale Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Medical School","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075093461","display_name":"Jeffrey Alan Lieberman","orcid":"https://orcid.org/0000-0002-1899-1776","observed_orcids":["https://orcid.org/0000-0002-1899-1776"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Lieberman","raw_affiliation_strings":["Columbia University, Department of Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, Department of Psychiatry","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2107,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8817058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"3","issue":"2","first_page":"253","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6119999885559082},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8050000071525574},{"id":"https://openalex.org/keywords/catie-trial","display_name":"CATIE trial","score":0.8629999756813049},{"id":"https://openalex.org/keywords/primary-outcomes","display_name":"primary outcomes","score":0.5830000042915344},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.8230000138282776},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6740000247955322},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.6679999828338623},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6769999861717224},{"id":"https://openalex.org/keywords/clinical-trial-endpoints","display_name":"clinical trial endpoints","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.9543960690498352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7165098190307617},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.5323999524116516},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5039271712303162},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44500142335891724},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.42599767446517944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42114678025245667},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.3943255543708801},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35841864347457886},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3000733554363251},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1198/sbr.2011.10013","doi":"https://doi.org/10.1198/sbr.2011.10013","is_oa":false,"landing_page_url":"https://doi.org/10.1198/sbr.2011.10013","pdf_url":null,"source":{"id":"https://openalex.org/S104563881","display_name":"Statistics in Biopharmaceutical Research","issn_l":"1946-6315","issn":["1946-6315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Biopharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:31031886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31031886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in biopharmaceutical research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5464069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6482974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6482974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6482974","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stat Biopharm Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5464069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6482974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G445903376","display_name":null,"funder_award_id":"N01 MH090001","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G827372995","display_name":"CLINICAL ANTIPSYCHOTIC TRIALS OF INTERVENTION EFFECTIVES","funder_award_id":"n01mh90001-21-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1571132164","https://openalex.org/W1580788756","https://openalex.org/W1912935324","https://openalex.org/W1973545544","https://openalex.org/W1974345349","https://openalex.org/W1989972396","https://openalex.org/W2014912086","https://openalex.org/W2028837391","https://openalex.org/W2034945547","https://openalex.org/W2070427088","https://openalex.org/W2105575181","https://openalex.org/W2116225616","https://openalex.org/W2129152730","https://openalex.org/W2149639459","https://openalex.org/W2151622084","https://openalex.org/W2159155203","https://openalex.org/W2167116216","https://openalex.org/W2167707145","https://openalex.org/W2180693160","https://openalex.org/W3147894994"],"related_works":["https://openalex.org/W142636245","https://openalex.org/W2276353761","https://openalex.org/W1993389714","https://openalex.org/W4248655202","https://openalex.org/W2994451727","https://openalex.org/W1971255792","https://openalex.org/W1965931174","https://openalex.org/W4251718241","https://openalex.org/W2058396682","https://openalex.org/W7099181530"],"abstract_inverted_index":{"Time":[0],"until":[1,62],"all-cause":[2],"treatment":[3,63,172],"discontinuation":[4,54,106,151,184],"was":[5],"the":[6,10,15,35,128,160],"primary":[7],"outcome":[8,192],"of":[9,19,37,47,71,81,105,112,116],"CATIE":[11],"trial.":[12],"We":[13,33],"discuss":[14],"advantages":[16],"and":[17,22,118,190],"disadvantages":[18],"this":[20],"outcome,":[21,60],"evaluate":[23],"its":[24],"association":[25],"with":[26,88,176],"clinical":[27,197],"correlates":[28],"through":[29],"graphical":[30],"response":[31],"profiles.":[32],"investigate":[34],"characteristics":[36],"patients":[38,125],"who":[39,66,95],"discontinued":[40,67,96],"for":[41,79,91,97,107,148,169,193],"patient":[42,48,98,108,140,154],"decision,":[43],"including":[44],"a":[45,58,133,188],"reclassification":[46,104],"decision":[49,99,109,141,155],"into":[50],"other":[51,75,92],"reasons.":[52],"All-cause":[53,183],"is":[55,185],"compared":[56,87],"to":[57,150,153,171],"related":[59],"time":[61,149,170],"failure.":[64],"Patients":[65,77],"had":[68,83,100],"lower":[69,101],"quality":[70],"life":[72],"scores":[73,86],"than":[74,136],"patients.":[76,93],"discontinuing":[78],"lack":[80,115],"efficacy":[82,85,117],"worsened":[84],"an":[89],"improvement":[90],"Those":[94],"compliance.":[102],"Blinded":[103],"identified":[110],"5%":[111],"cases":[113],"as":[114,120,139,187],"21%":[119],"intolerable":[121],"side":[122],"effects.":[123],"Reclassified":[124],"participated":[126],"in":[127],"next":[129],"study":[130],"phase":[131],"at":[132],"higher":[134],"rate":[135],"those":[137],"remaining":[138],"(67%":[142],"vs.":[143],"10%).":[144],"Treatment":[145,167],"group":[146],"differences":[147],"due":[152],"were":[156,164,174],"attenuated":[157],"after":[158],"censoring":[159],"reclassified":[161],"patients,":[162],"but":[163],"still":[165],"suggestive.":[166],"comparisons":[168],"failure":[173],"consistent":[175],"all":[177],"cause":[178],"discontinuation,":[179],"although":[180],"somewhat":[181],"smaller.":[182],"recommended":[186],"simple":[189],"comprehensive":[191],"pharmaceutical":[194],"Phase":[195],"II-IV":[196],"trials.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}