{"id":"https://openalex.org/W2010160980","doi":"https://doi.org/10.1073/pnas.261381198","title":"A second iron-regulatory system in yeast independent of Aft1p","display_name":"A second iron-regulatory system in yeast independent of Aft1p","publication_year":2001,"publication_date":"2001-12-04","ids":{"openalex":"https://openalex.org/W2010160980","doi":"https://doi.org/10.1073/pnas.261381198","mag":"2010160980","pmid":"https://pubmed.ncbi.nlm.nih.gov/11734641","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/64680"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.261381198","doi":"https://doi.org/10.1073/pnas.261381198","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.261381198","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/64680","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085587138","display_name":"Julian C. Rutherford","orcid":"https://orcid.org/0000-0001-5503-2817","observed_orcids":["https://orcid.org/0000-0001-5503-2817"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julian C. Rutherford","raw_affiliation_strings":["University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019230819","display_name":"Shulamit Jaron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shulamit Jaron","raw_affiliation_strings":["University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065593005","display_name":"Esha Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esha Ray","raw_affiliation_strings":["University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065906655","display_name":"Patrick O. Brown","orcid":"https://orcid.org/0000-0002-9940-5993","observed_orcids":["https://orcid.org/0000-0002-9940-5993"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick O. Brown","raw_affiliation_strings":["University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165","https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052419395","display_name":"Dennis R. Winge","orcid":"https://orcid.org/0000-0003-1160-1189","observed_orcids":["https://orcid.org/0000-0003-1160-1189"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis R. Winge","raw_affiliation_strings":["University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428","HEMATOLOGY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Sciences Center, Departments of Medicine\r and Biochemistry, Salt Lake City, Utah 84132; and\r Department of Biochemistry, Stanford University School of\r Medicine, Howard Hughes Medical Institute, Stanford, CA 94305-5428","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"HEMATOLOGY","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4622,"has_fulltext":false,"cited_by_count":154,"citation_normalized_percentile":{"value":0.93702876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"98","issue":"25","first_page":"14322","last_page":"14327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.2506999969482422,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11418","display_name":"Plant Micronutrient Interactions and Effects","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/iron-regulon","display_name":"iron regulon","score":0.8209999799728394},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8949999809265137},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.609000027179718},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.45899999141693115},{"id":"https://openalex.org/keywords/iron-absorption","display_name":"iron absorption","score":0.5709999799728394},{"id":"https://openalex.org/keywords/transcription-factor-binding","display_name":"transcription factor binding","score":0.43799999356269836},{"id":"https://openalex.org/keywords/functional-redundancy","display_name":"functional redundancy","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.8141981363296509},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.7959573268890381},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7131714224815369},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7131103873252869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6412810683250427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5712418556213379},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4921264052391052},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.47975313663482666},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.43721094727516174},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.41111594438552856},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34049010276794434}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.261381198","doi":"https://doi.org/10.1073/pnas.261381198","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.261381198","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:64680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/64680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:11734641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11734641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34579332","doi":"https://doi.org/10.25405/ncl.34579332","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34579332","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34579332.v1","doi":"https://doi.org/10.25405/ncl.34579332.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34579332.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:64680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/64680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2481016289","display_name":"FUNCTIONAL MAP OF THE YEAST GENOME","funder_award_id":"R01HG000983","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2669903963","display_name":"Assembly of Redox Metal Centers in Cytochrome Oxidase","funder_award_id":"R01ES003817","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2884375496","display_name":null,"funder_award_id":"61286","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3256372205","display_name":"Metal Homeostatic Mechanisms in Yeast","funder_award_id":"R01CA061286","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4466249638","display_name":null,"funder_award_id":"ES03817","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8180040734","display_name":"METAL CHELATION IN PROTEINS WITH POLYMETALLIC CLUSTERS","funder_award_id":"R37ES003817","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000297069","display_name":null,"funder_award_id":"ES03817","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000895596","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA042014","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320310050","display_name":"University of Utah","ror":"https://ror.org/03r0ha626"},{"id":"https://openalex.org/F4320312217","display_name":"Huntsman Cancer Foundation","ror":"https://ror.org/03v7tx966"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1534809362","https://openalex.org/W1588727306","https://openalex.org/W1641544182","https://openalex.org/W1963142741","https://openalex.org/W1967432418","https://openalex.org/W1968898079","https://openalex.org/W1969836426","https://openalex.org/W1974015253","https://openalex.org/W1980041175","https://openalex.org/W2039524523","https://openalex.org/W2046440396","https://openalex.org/W2047906206","https://openalex.org/W2053388782","https://openalex.org/W2062435249","https://openalex.org/W2073461422","https://openalex.org/W2074700700","https://openalex.org/W2077667351","https://openalex.org/W2080390432","https://openalex.org/W2111379154","https://openalex.org/W2118567506","https://openalex.org/W2137683543","https://openalex.org/W2157177321","https://openalex.org/W2165011536","https://openalex.org/W2169333620"],"related_works":["https://openalex.org/W2144070387","https://openalex.org/W1969836426","https://openalex.org/W7097570708","https://openalex.org/W1795197235","https://openalex.org/W1992758160","https://openalex.org/W3176113976","https://openalex.org/W7222430002","https://openalex.org/W2082152349","https://openalex.org/W7062757398","https://openalex.org/W2046440396"],"abstract_inverted_index":{"Iron":[0],"homeostasis":[1],"in":[2,23,122,193,202],"the":[3,10,17,63,72,84,97,106,110,118,138,164,189,221],"yeast":[4,29,214],"Saccharomyces":[5],"cerevisiae":[6],"is":[7],"regulated":[8,133,145],"at":[9],"transcriptional":[11,175],"level":[12],"by":[13,134,146,163],"Aft1p,":[14],"which":[15,36],"activates":[16],"expression":[18],"of":[19,34,91,96,105,109,120,137,153,157,159,179,198],"its":[20],"target":[21],"genes":[22,132,140,161],"response":[24,203],"to":[25,79,102,130,143,184,204],"low-iron":[26,80,207],"conditions.":[27,208],"The":[28,113,155,195],"genome":[30],"contains":[31],"a":[32,50,53,173,185,216],"paralog":[33],"AFT1,":[35],"has":[37,215],"been":[38],"designated":[39],"AFT2.":[40,135],"To":[41],"establish":[42],"whether":[43],"AFT1":[44,225],"and":[45,181,226],"AFT2":[46,92,99,199,227],"have":[47],"overlapping":[48],"functions,":[49],"mutant":[51,89],"containing":[52,188],"double":[54],"aft1Deltaaft2Delta":[55,74],"deletion":[56],"was":[57,76,151],"generated.":[58],"Growth":[59],"assays":[60],"established":[61],"that":[62,213],"single":[64],"aft2Delta":[65],"strain":[66,75],"exhibited":[67],"no":[68],"iron-dependent":[69],"phenotype.":[70],"However,":[71],"double-mutant":[73],"more":[77],"sensitive":[78],"growth":[81,205],"conditions":[82],"than":[83],"single-mutant":[85],"aft1Delta":[86,111,124],"strain.":[87,112,125],"A":[88],"allele":[90,115,166,197],"(AFT2-1(up)),":[93],"or":[94],"overexpression":[95],"wild-type":[98,196],"gene,":[100],"led":[101],"partial":[103],"complementation":[104],"respiratory-deficient":[107],"phenotype":[108],"AFT2-1(up)":[114,165],"also":[116],"increased":[117],"uptake":[119],"(59)Fe":[121],"an":[123],"DNA":[126,186],"microarrays":[127],"were":[128],"used":[129],"identify":[131],"Some":[136],"AFT2-regulated":[139],"are":[141,167],"known":[142],"be":[144],"Aft1p;":[147],"however,":[148],"AFT2-1(up)-dependent":[149],"activation":[150],"independent":[152],"Aft1p.":[154],"kinetics":[156],"induction":[158],"two":[160],"activated":[162,200],"consistent":[168],"with":[169,224],"Aft2p":[170,182],"acting":[171],"as":[172],"direct":[174],"factor.":[176],"Truncated":[177],"forms":[178],"Aft1p":[180,190],"bound":[183],"duplex":[187],"binding":[191],"site":[192],"vitro.":[194],"transcription":[201],"under":[206],"Together,":[209],"these":[210],"data":[211],"suggest":[212],"second":[217],"regulatory":[218],"pathway":[219],"for":[220],"iron":[222],"regulon,":[223],"playing":[228],"partially":[229],"redundant":[230],"roles.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}