{"id":"https://openalex.org/W2010142668","doi":"https://doi.org/10.1073/pnas.64.4.1300","title":"Escherichia coli MUTANTS DEFECTIVE IN CHEMOTAXIS TOWARD SPECIFIC CHEMICALS","display_name":"Escherichia coli MUTANTS DEFECTIVE IN CHEMOTAXIS TOWARD SPECIFIC CHEMICALS","publication_year":1969,"publication_date":"1969-12-01","ids":{"openalex":"https://openalex.org/W2010142668","doi":"https://doi.org/10.1073/pnas.64.4.1300","mag":"2010142668","pmid":"https://pubmed.ncbi.nlm.nih.gov/4916925","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/223283"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.64.4.1300","doi":"https://doi.org/10.1073/pnas.64.4.1300","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.64.4.1300","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC223283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051475312","display_name":"Gerald L. Hazelbauer","orcid":"https://orcid.org/0000-0003-2449-2663","observed_orcids":["https://orcid.org/0000-0003-2449-2663"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald L. Hazelbauer","raw_affiliation_strings":["DEPARTMENT OF BIOCHEMISTRY, UNIVERSITY OF WISCONSIN, MADISON","DEPARTMENT OF GENETICS, UNIVERSITY OF WISCONSIN, MADISON"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPARTMENT OF BIOCHEMISTRY, UNIVERSITY OF WISCONSIN, MADISON","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"DEPARTMENT OF GENETICS, UNIVERSITY OF WISCONSIN, MADISON","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077092038","display_name":"Robert Mesibov","orcid":"https://orcid.org/0000-0003-3466-5038","observed_orcids":["https://orcid.org/0000-0003-3466-5038"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Mesibov","raw_affiliation_strings":["DEPARTMENT OF BIOCHEMISTRY, UNIVERSITY OF WISCONSIN, MADISON","DEPARTMENT OF GENETICS, UNIVERSITY OF WISCONSIN, MADISON"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPARTMENT OF BIOCHEMISTRY, UNIVERSITY OF WISCONSIN, MADISON","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"DEPARTMENT OF GENETICS, UNIVERSITY OF WISCONSIN, MADISON","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021494728","display_name":"Julius Adler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julius Adler","raw_affiliation_strings":["DEPARTMENT OF BIOCHEMISTRY, UNIVERSITY OF WISCONSIN, MADISON","DEPARTMENT OF GENETICS, UNIVERSITY OF WISCONSIN, MADISON"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DEPARTMENT OF BIOCHEMISTRY, UNIVERSITY OF WISCONSIN, MADISON","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"DEPARTMENT OF GENETICS, UNIVERSITY OF WISCONSIN, MADISON","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":2.566,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.89508507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"64","issue":"4","first_page":"1300","last_page":"1307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/chemotaxis-mutants","display_name":"chemotaxis mutants","score":0.8920000195503235},{"id":"https://openalex.org/keywords/chemoreceptors","display_name":"chemoreceptors","score":0.8180000185966492},{"id":"https://openalex.org/keywords/l-serine","display_name":"L-serine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":0.9399999976158142},{"id":"https://openalex.org/keywords/galactose-uptake","display_name":"galactose uptake","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sugar-uptake","display_name":"sugar uptake","score":0.5130000114440918},{"id":"https://openalex.org/keywords/chemotaxis-model","display_name":"chemotaxis model","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.9580579996109009},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.8149929046630859},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.8005197048187256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5974358916282654},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.5325666069984436},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5222775936126709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4966438412666321},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4743194282054901},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.384341299533844},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2388874590396881},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06253045797348022},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05747002363204956}],"mesh":[{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005827","descriptor_name":"Genetics, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012266","descriptor_name":"Ribose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.64.4.1300","doi":"https://doi.org/10.1073/pnas.64.4.1300","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.64.4.1300","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:449455","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC223283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:223283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/223283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:4916925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4916925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:449455","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC223283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1531708193","https://openalex.org/W2013957981","https://openalex.org/W2105956063","https://openalex.org/W2145986958","https://openalex.org/W2339621323"],"related_works":["https://openalex.org/W2145986958","https://openalex.org/W2134864306","https://openalex.org/W2062775683","https://openalex.org/W1480143905","https://openalex.org/W2061597136","https://openalex.org/W2094617710","https://openalex.org/W4235785959","https://openalex.org/W1920238277","https://openalex.org/W2064891232","https://openalex.org/W2296456993"],"abstract_inverted_index":{"Mutants":[0],"of":[1,38,83],"Escherichia":[2],"coli":[3],"K12":[4],"have":[5],"been":[6],"found":[7],"which":[8,89],"fail":[9],"to":[10,46],"carry":[11],"out":[12],"chemotaxis":[13,23,59,73,87],"toward":[14,24],"certain":[15,49],"chemicals":[16],"only.":[17],"One":[18],"mutant":[19,42],"exhibits":[20],"greatly":[21],"reduced":[22],"L-serine":[25],"but":[26],"has":[27],"no":[28],"detectable":[29],"defect":[30,60,63],"either":[31],"in":[32,35,64,81,88],"uptake":[33,75],"or":[34],"oxidative":[36],"metabolism":[37],"that":[39],"compound.":[40],"Another":[41],"is":[43,53],"not":[44],"attracted":[45],"D-galactose":[47],"and":[48,61,74],"related":[50],"sugars.":[51],"There":[52],"a":[54,62,69,84],"correlation":[55],"between":[56],"the":[57],"galactose":[58,65],"uptake,":[66],"perhaps":[67],"indicating":[68],"common":[70],"component":[71],"for":[72,86],"systems.":[76],"The":[77],"results":[78],"are":[79,91],"discussed":[80],"terms":[82],"model":[85],"attractants":[90],"detected":[92],"by":[93],"specific":[94],"\"chemoreceptors.\"":[95]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}