{"id":"https://openalex.org/W2010131007","doi":"https://doi.org/10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","title":"Correction: A Systematic Proteomic Study of Irradiated DNA Repair Deficient Nbn-Mice","display_name":"Correction: A Systematic Proteomic Study of Irradiated DNA Repair Deficient Nbn-Mice","publication_year":2009,"publication_date":"2009-05-15","ids":{"openalex":"https://openalex.org/W2010131007","doi":"https://doi.org/10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","mag":"2010131007"},"language":"en","primary_location":{"id":"doi:10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","doi":"https://doi.org/10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","is_oa":true,"landing_page_url":"https://doi.org/10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","pdf_url":"https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0005423","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"erratum","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0005423","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016713012","display_name":"Anna Melchers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Melchers","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003415149","display_name":"Lars St\u00f6ckl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars St\u00f6ckl","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067390256","display_name":"Janina Radszewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janina Radszewski","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023612514","display_name":"Marco Anders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marco Anders","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086608452","display_name":"Harald Krenzlin","orcid":"https://orcid.org/0000-0002-9001-8006","observed_orcids":["https://orcid.org/0000-0002-9001-8006"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Harald Krenzlin","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071965817","display_name":"Candy Kalischke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Candy Kalischke","raw_affiliation_strings":["Medizinische Klinik mit Schwerpunkt Ha \u00a8matologie/Onkologie, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik mit Schwerpunkt Ha \u00a8matologie/Onkologie, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104061740","display_name":"Regina Scholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Regina Scholz","raw_affiliation_strings":["Klinik fu \u00a8r Strahlenheilkunde, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik fu \u00a8r Strahlenheilkunde, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110018647","display_name":"Andreas Jordan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Jordan","raw_affiliation_strings":["Klinik fu \u00a8r Strahlenheilkunde, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik fu \u00a8r Strahlenheilkunde, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024144929","display_name":"Grit Nebrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Grit Nebrich","raw_affiliation_strings":["Buck Institute for Age Research , United States of America","Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Age Research , United States of America","institution_ids":["https://openalex.org/I1337826666"]},{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111413739","display_name":"Joachim Klose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Klose","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062257202","display_name":"Karl Sperling","orcid":"https://orcid.org/0000-0003-2305-4370","observed_orcids":["https://orcid.org/0000-0003-2305-4370"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Sperling","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060871912","display_name":"Martin Digweed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Digweed","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074668286","display_name":"Ilja Demuth","orcid":"https://orcid.org/0000-0002-4340-2523","observed_orcids":["https://orcid.org/0000-0002-4340-2523"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ilja Demuth","raw_affiliation_strings":["Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu \u00a8r Humangenetik, Center for Biomedical Nanotechnology, Charite \u00b4-Universita \u00a8tsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074668286"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.1282999962568283,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niobium-nitride","display_name":"niobium nitride","score":0.628000020980835},{"id":"https://openalex.org/keywords/nbs1","display_name":"NBS1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nijmegen-breakage-syndrome","display_name":"Nijmegen breakage syndrome","score":0.8619999885559082},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.902999997138977},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9129999876022339},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9710000157356262},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.6179999709129333},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5285666584968567},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4921974241733551},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.43664079904556274},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3959493339061737},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3767487406730652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36088094115257263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24750149250030518},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19895103573799133},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.07048225402832031}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","doi":"https://doi.org/10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","is_oa":true,"landing_page_url":"https://doi.org/10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","pdf_url":"https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0005423","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2685747","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2685747","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5df7dccac4014df0b88e369fc0baec07","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5df7dccac4014df0b88e369fc0baec07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 5 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","doi":"https://doi.org/10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","is_oa":true,"landing_page_url":"https://doi.org/10.1371/annotation/06306df9-1db3-4e7b-a7ce-18338b655967","pdf_url":"https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0005423","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3621752323","display_name":null,"funder_award_id":"DE 842-2-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G671292396","display_name":null,"funder_award_id":"SFB 577","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010131007.pdf","grobid_xml":"https://content.openalex.org/works/W2010131007.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W182342000","https://openalex.org/W1511602705","https://openalex.org/W1558103766","https://openalex.org/W1963513209","https://openalex.org/W1964140277","https://openalex.org/W1969638751","https://openalex.org/W1975627280","https://openalex.org/W1976108918","https://openalex.org/W1978438460","https://openalex.org/W1980660634","https://openalex.org/W1981123464","https://openalex.org/W1984889393","https://openalex.org/W1988951520","https://openalex.org/W1989446240","https://openalex.org/W1995002748","https://openalex.org/W2008743975","https://openalex.org/W2023716699","https://openalex.org/W2036395605","https://openalex.org/W2038970416","https://openalex.org/W2039627804","https://openalex.org/W2041079773","https://openalex.org/W2045526190","https://openalex.org/W2053658205","https://openalex.org/W2056913009","https://openalex.org/W2062029746","https://openalex.org/W2078932864","https://openalex.org/W2082981258","https://openalex.org/W2084089807","https://openalex.org/W2089721587","https://openalex.org/W2099461488","https://openalex.org/W2106410227","https://openalex.org/W2110394056","https://openalex.org/W2111760763","https://openalex.org/W2114467922","https://openalex.org/W2115157125","https://openalex.org/W2120365943","https://openalex.org/W2128249118","https://openalex.org/W2140647923","https://openalex.org/W2143634333","https://openalex.org/W2152054208","https://openalex.org/W2155836063","https://openalex.org/W2163968456","https://openalex.org/W2165081418","https://openalex.org/W2166663643","https://openalex.org/W2170122994","https://openalex.org/W4253495864"],"related_works":["https://openalex.org/W1966150463","https://openalex.org/W2011920712","https://openalex.org/W6943845068","https://openalex.org/W1792718914","https://openalex.org/W2111760763","https://openalex.org/W2050062246","https://openalex.org/W2127118677","https://openalex.org/W2155836063","https://openalex.org/W2165762767","https://openalex.org/W2152054208"],"abstract_inverted_index":{"Background:":[0],"The":[1],"NBN":[2,23,128],"gene":[3,24],"codes":[4],"for":[5],"the":[6,13,56,166],"protein":[7],"nibrin,":[8],"which":[9],"is":[10,25],"involved":[11,91],"in":[12,27,39,55,60,70,75,85,92,127,160],"detection":[14],"and":[15,95,149,174],"repair":[16,172],"of":[17,58,81,101,105,114,120,154,169],"DNA":[18],"double":[19],"strand":[20],"breaks":[21],"(DSBs).The":[22],"essential":[26],"mammals.":[28],"Methodology/Principal":[29],"Findings:We":[30],"have":[31],"used":[32],"a":[33,40,150,170],"conditional":[34],"null":[35,72,86,107],"mutant":[36,73,87,108],"mouse":[37],"model":[38],"proteomics":[41],"approach":[42],"to":[43,77,130,165],"identify":[44],"proteins":[45,82],"with":[46,145],"modified":[47],"expression":[48],"levels":[49],"after":[50],"4":[51],"Gy":[52],"ionizing":[53],"irradiation":[54],"absence":[57],"nibrin":[59],"vivo.Altogether,":[61],"amongst":[62],",8,000":[63],"resolved":[64],"proteins,":[65],"209":[66],"were":[67,89],"differentially":[68],"expressed":[69],"homozygous":[71],"mice":[74,88],"comparison":[76],"control":[78],"animals.One":[79],"group":[80],"significantly":[83],"altered":[84],"those":[90],"oxidative":[93,175],"stress":[94],"cellular":[96],"redox":[97],"homeostasis":[98],"(p,0.0001).In":[99],"substantiation":[100],"this":[102],"finding,":[103],"analysis":[104],"Nbn":[106],"fibroblasts":[109],"indicated":[110],"an":[111,135],"increased":[112],"production":[113],"reactive":[115],"oxygen":[116],"species":[117],"following":[118],"induction":[119],"DSBs.Conclusions/Significance:":[121],"In":[122],"humans,":[123],"biallelic":[124],"hypomorphic":[125],"mutations":[126],"lead":[129],"Nijmegen":[131],"breakage":[132],"syndrome":[133],"(NBS),":[134],"autosomal":[136],"recessive":[137],"genetic":[138],"disease":[139],"characterised":[140],"by":[141],"extreme":[142],"radiosensitivity":[143],"coupled":[144],"growth":[146],"retardation,":[147],"immunoinsufficiency":[148],"very":[151],"high":[152,157],"risk":[153,159],"malignancy.This":[155],"particularly":[156],"cancer":[158],"NBS":[161],"may":[162],"be":[163],"attributable":[164],"compound":[167],"effect":[168],"DSB":[171],"defect":[173],"stress.":[176]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
