{"id":"https://openalex.org/W2010123882","doi":"https://doi.org/10.1083/jcb.63.1.125","title":"ENZYME LOCALIZATION IN THE ANAEROBIC MITOCHONDRIA OF ASCARIS LUMBRICOIDES","display_name":"ENZYME LOCALIZATION IN THE ANAEROBIC MITOCHONDRIA OF ASCARIS LUMBRICOIDES","publication_year":1974,"publication_date":"1974-10-01","ids":{"openalex":"https://openalex.org/W2010123882","doi":"https://doi.org/10.1083/jcb.63.1.125","mag":"2010123882","pmid":"https://pubmed.ncbi.nlm.nih.gov/4153873","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2109336"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.63.1.125","doi":"https://doi.org/10.1083/jcb.63.1.125","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.63.1.125","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2109336/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086768019","display_name":"Robert S. Rew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Rew","raw_affiliation_strings":["From the Department of Biology, University of Notre Dame, Notre Dame, Indiana 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013097300","display_name":"Howard J. Saz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard J. Saz","raw_affiliation_strings":["From the Department of Biology, University of Notre Dame, Notre Dame, Indiana 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107639228"],"apc_list":null,"apc_paid":null,"fwci":1.4567,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.78829622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"63","issue":"1","first_page":"125","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascaris-lumbricoides","display_name":"Ascaris lumbricoides","score":0.9639999866485596},{"id":"https://openalex.org/keywords/succinate-dehydrogenase","display_name":"succinate dehydrogenase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nadh-oxidase","display_name":"NADH oxidase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mg2-dependent-atpase","display_name":"Mg2+-dependent ATPase","score":0.8339999914169312},{"id":"https://openalex.org/keywords/adenylate-kinase","display_name":"adenylate kinase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/citrate-synthase","display_name":"citrate synthase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cytochrome-c-reductase","display_name":"cytochrome c reductase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fumarase","display_name":"fumarase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/malic-enzyme","display_name":"malic enzyme","score":0.8379999995231628},{"id":"https://openalex.org/keywords/intermembrane-space","display_name":"intermembrane space","score":0.9760000109672546},{"id":"https://openalex.org/keywords/proton-pumping","display_name":"proton translocation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mitochondrial-matrix","display_name":"mitochondrial matrix","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C186850619","wikidata":"https://www.wikidata.org/wiki/Q1425206","display_name":"Intermembrane space","level":5,"score":0.8927942514419556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7953678369522095},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6953307390213013},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6438322067260742},{"id":"https://openalex.org/C2777364306","wikidata":"https://www.wikidata.org/wiki/Q468771","display_name":"Ascaris lumbricoides","level":3,"score":0.6251096129417419},{"id":"https://openalex.org/C2779845534","wikidata":"https://www.wikidata.org/wiki/Q2062253","display_name":"Ascaris suum","level":3,"score":0.48846378922462463},{"id":"https://openalex.org/C111133373","wikidata":"https://www.wikidata.org/wiki/Q21132608","display_name":"Citrate synthase","level":3,"score":0.4713285267353058},{"id":"https://openalex.org/C106302636","wikidata":"https://www.wikidata.org/wiki/Q21107515","display_name":"Fumarase","level":3,"score":0.4529414176940918},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.4482088088989258},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.4241888225078583},{"id":"https://openalex.org/C3075310","wikidata":"https://www.wikidata.org/wiki/Q356718","display_name":"Energy charge","level":4,"score":0.4192917048931122},{"id":"https://openalex.org/C2780492224","wikidata":"https://www.wikidata.org/wiki/Q310838","display_name":"Ascaris","level":3,"score":0.41720864176750183},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4092346429824829},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3409680724143982},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.1667863130569458},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.0},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001200","descriptor_name":"Ascaris","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001200","descriptor_name":"Ascaris","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001200","descriptor_name":"Ascaris","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002950","descriptor_name":"Citrate (si)-Synthase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003579","descriptor_name":"Cytochrome Reductases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008291","descriptor_name":"Malate Dehydrogenase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008931","descriptor_name":"Mitochondria, Muscle","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008931","descriptor_name":"Mitochondria, Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008931","descriptor_name":"Mitochondria, Muscle","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009247","descriptor_name":"NADH, NADPH Oxidoreductases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011768","descriptor_name":"Pyruvate Dehydrogenase Complex","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.63.1.125","doi":"https://doi.org/10.1083/jcb.63.1.125","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.63.1.125","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2109336","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2109336/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2109336/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:914129","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2109336","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:4153873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4153873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.281.5188","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.281.5188","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/fa/0c/J_Cell_Biol_1974_Oct_1_63(1)_125-135.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2109336","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2109336/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2109336/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010123882.pdf","grobid_xml":"https://content.openalex.org/works/W2010123882.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W30038258","https://openalex.org/W57536650","https://openalex.org/W1204726008","https://openalex.org/W1482959078","https://openalex.org/W1754830538","https://openalex.org/W1775749144","https://openalex.org/W1964041346","https://openalex.org/W1964242540","https://openalex.org/W1965019427","https://openalex.org/W1969805452","https://openalex.org/W1974496651","https://openalex.org/W1982218078","https://openalex.org/W1994910433","https://openalex.org/W2002490824","https://openalex.org/W2034905306","https://openalex.org/W2036974877","https://openalex.org/W2057886309","https://openalex.org/W2062381871","https://openalex.org/W2063638273","https://openalex.org/W2073028730","https://openalex.org/W2076672199","https://openalex.org/W2086657981","https://openalex.org/W2093225727","https://openalex.org/W2109401564","https://openalex.org/W2125562918","https://openalex.org/W2127911529","https://openalex.org/W2130344015","https://openalex.org/W2285348475","https://openalex.org/W2313402945","https://openalex.org/W2412816959"],"related_works":["https://openalex.org/W2059697952","https://openalex.org/W1603402945","https://openalex.org/W1867633062","https://openalex.org/W2035362772","https://openalex.org/W1485106019","https://openalex.org/W2073028730","https://openalex.org/W2010098058","https://openalex.org/W2081878393","https://openalex.org/W2151530024","https://openalex.org/W119431989"],"abstract_inverted_index":{"Mitochondria":[0],"from":[1,95],"the":[2,5,84,96,101,109,125],"muscle":[3],"of":[4,39,100,134],"parasitic":[6],"nematode":[7],"Ascaris":[8,114],"lumbricoides":[9],"var.":[10],"suum":[11],"function":[12],"anaerobically":[13],"in":[14,50,78,113,124],"electron":[15],"transport-associated":[16],"phosphorylations":[17],"under":[18],"physiological":[19],"conditions.":[20],"These":[21,104],"helminth":[22],"organelles":[23],"have":[24],"been":[25],"fractionated":[26],"into":[27],"inner":[28],"and":[29,33,44,54,68,88,115,131],"outer":[30],"membrane,":[31],"matrix,":[32],"intermembrane":[34,97,126],"space":[35,98],"fractions.":[36],"The":[37,128],"distributions":[38,48],"enzyme":[40,91],"systems":[41],"were":[42,72,92],"determined":[43,73],"compared":[45],"with":[46,83],"corresponding":[47],"reported":[49],"mammalian":[51,79,85],"mitochondria.":[52,80,103],"Succinate":[53],"pyruvate":[55],"dehydrogenases":[56],"as":[57,59,77],"well":[58],"NADH":[60,123],"oxidase,":[61],"Mg(++)-dependent":[62],"ATPase,":[63],"adenylate":[64],"kinase,":[65],"citrate":[66],"synthase,":[67],"cytochrome":[69],"c":[70],"reductases":[71],"to":[74,119,122,139],"be":[75,117],"distributed":[76],"In":[81],"contrast":[82],"systems,":[86],"fumarase":[87],"NAD-linked":[89],"\"malic\"":[90],"isolated":[93],"primarily":[94],"fraction":[99],"worm":[102],"enzymes":[105],"are":[106],"required":[107],"for":[108,130],"anaerobic":[110],"energy-generating":[111],"system":[112,138],"would":[116],"expected":[118],"give":[120],"rise":[121],"space.":[127],"need":[129],"possible":[132],"mechanism":[133],"a":[135],"proton":[136],"translocation":[137],"obtain":[140],"energy":[141],"generation":[142],"is":[143],"suggested.":[144]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}