{"id":"https://openalex.org/W2010120109","doi":"https://doi.org/10.1093/brain/99.3.459","title":"NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES","display_name":"NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W2010120109","doi":"https://doi.org/10.1093/brain/99.3.459","mag":"2010120109","pmid":"https://pubmed.ncbi.nlm.nih.gov/11871"},"language":"en","primary_location":{"id":"doi:10.1093/brain/99.3.459","doi":"https://doi.org/10.1093/brain/99.3.459","is_oa":false,"landing_page_url":"https://doi.org/10.1093/brain/99.3.459","pdf_url":null,"source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111070537","display_name":"David M. Bowen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"DAVID M. BOWEN","raw_affiliation_strings":["From the Miriam Marks Department of Neurochemistry, Institute of Neurology, The National Hospital Queen Square, London WCIN 3BG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Miriam Marks Department of Neurochemistry, Institute of Neurology, The National Hospital Queen Square, London WCIN 3BG","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000550919","display_name":"Carolyn Beebe Smith","orcid":"https://orcid.org/0000-0002-2722-0180","observed_orcids":["https://orcid.org/0000-0002-2722-0180"]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"CAROLYN B. SMITH","raw_affiliation_strings":["From the Miriam Marks Department of Neurochemistry, Institute of Neurology, The National Hospital Queen Square, London WCIN 3BG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Miriam Marks Department of Neurochemistry, Institute of Neurology, The National Hospital Queen Square, London WCIN 3BG","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018546588","display_name":"Pamela White","orcid":"https://orcid.org/0000-0001-6735-2770","observed_orcids":["https://orcid.org/0000-0001-6735-2770"]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"PAMELA WHITE","raw_affiliation_strings":["From the Miriam Marks Department of Neurochemistry, Institute of Neurology, The National Hospital Queen Square, London WCIN 3BG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Miriam Marks Department of Neurochemistry, Institute of Neurology, The National Hospital Queen Square, London WCIN 3BG","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111624546","display_name":"ALAN N. DAVISON","orcid":"https://orcid.org/0000-0002-3478-0231","observed_orcids":["https://orcid.org/0000-0002-3478-0231"]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"ALAN N. DAVISON","raw_affiliation_strings":["From the Miriam Marks Department of Neurochemistry, Institute of Neurology, The National Hospital Queen Square, London WCIN 3BG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Miriam Marks Department of Neurochemistry, Institute of Neurology, The National Hospital Queen Square, London WCIN 3BG","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4224,"currency":"GBP","value_usd":5570},"apc_paid":null,"fwci":28.3734,"has_fulltext":false,"cited_by_count":1313,"citation_normalized_percentile":{"value":0.99847627,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"99","issue":"3","first_page":"459","last_page":"496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.32010000944137573,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1907999962568283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senile-dementia","display_name":"senile dementia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cholinergic-neurons","display_name":"cholinergic neurons","score":0.7250000238418579},{"id":"https://openalex.org/keywords/choline-acetyltransferase","display_name":"choline acetyltransferase","score":0.746999979019165},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/aspartate-decarboxylase","display_name":"aspartate decarboxylase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cerebral-hypoxia","display_name":"cerebral hypoxia","score":0.7829999923706055},{"id":"https://openalex.org/keywords/postmortem-autolysis","display_name":"postmortem autolysis","score":0.6880000233650208},{"id":"https://openalex.org/keywords/agonal-state","display_name":"agonal state","score":0.7229999899864197},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.7799999713897705},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.5690000057220459},{"id":"https://openalex.org/keywords/neuronal-proteins","display_name":"neuronal proteins","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6871311664581299},{"id":"https://openalex.org/C2778868616","wikidata":"https://www.wikidata.org/wiki/Q1076421","display_name":"Chorea","level":3,"score":0.6648695468902588},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6255918145179749},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5759148597717285},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.5186583399772644},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.5087113976478577},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4919759929180145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4879903197288513},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.4523053467273712},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.4418075382709503},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4258020222187042},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4226021468639374},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.368797242641449},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34665945172309875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33707118034362793},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1773407757282257}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001996","descriptor_name":"Bronchopneumonia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002421","descriptor_name":"Caudate Nucleus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002421","descriptor_name":"Caudate Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002534","descriptor_name":"Hypoxia, Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002795","descriptor_name":"Choline O-Acetyltransferase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011180","descriptor_name":"Postmortem Changes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011655","descriptor_name":"Pulmonary Embolism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/brain/99.3.459","doi":"https://doi.org/10.1093/brain/99.3.459","is_oa":false,"landing_page_url":"https://doi.org/10.1093/brain/99.3.459","pdf_url":null,"source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmid:11871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1606587171","https://openalex.org/W267438363","https://openalex.org/W2043604149","https://openalex.org/W2151300745","https://openalex.org/W2124540184","https://openalex.org/W2086226132","https://openalex.org/W2253998591","https://openalex.org/W2035873511","https://openalex.org/W2032546053","https://openalex.org/W138376471"],"abstract_inverted_index":{"Fifty-six":[0],"brains":[1,52],"from":[2],"middle-aged":[3],"and":[4,12,21,63,92,96,99,167,210,228,231,235,264,266,314],"elderly":[5],"normal":[6],"as":[7,9],"well":[8],"demented":[10],"subjects":[11],"patients":[13,348,413,416],"with":[14,129,366,417],"provisional":[15],"clinical":[16],"diagnosis":[17],"of":[18,40,43,61,89,102,121,134,138,143,249,260,269,306,331,351,355,369,373,403],"other":[19,220,418],"neurological":[20],"psychiatric":[22],"diseases":[23],"were":[24,32,109,124,252],"assessed":[25,83],"histologically.":[26],"On":[27],"this":[28,391],"basis":[29],"the":[30,77,86,90,100,116,132,136,151,171,184,199,219,243,267,282,304,307,312,318,329,353,356,367,370,374,380,386,401,404],"specimens":[31],"classified":[33],"into":[34],"14":[35],"diagnostic":[36],"groups.":[37],"A":[38],"survey":[39],"potential":[41,59,141],"indices":[42],"specific":[44,64],"neurons":[45,214],"has":[46,80],"been":[47,67,81],"carried":[48],"out":[49],"on":[50,193,397],"these":[51,332,412],"in":[53,69,150,176,183,205,218,239,255,291,342,361,411,415,427],"which":[54,310,358],"neurotransmitter-related":[55],"enzymes,":[56],"gamma-GTP":[57,97,234],"(a":[58],"index":[60,142],"capillaries)":[62],"proteins":[65],"have":[66],"determined":[68],"up":[70],"to":[71,111,126,131,147,196,242,278,317,338,376,395],"20":[72],"brain":[73,261,273,319,333],"regions.":[74],"In":[75,346],"addition,":[76],"agonal":[78,117,283],"state":[79,305,382],"tentatively":[82],"by":[84,115,281,298,303,423],"examining":[85],"post-mortem":[87,299],"states":[88],"circulatory":[91],"respiratory":[93],"systems.":[94],"CAT":[95,139,165],"activities":[98,259],"concentration":[101,268],"a":[103,156,160,424],"soluble":[104,244,271],"neuronal-type":[105],"protein":[106,247,274],"(neuronin":[107,275],"S-5)":[108],"found":[110],"be":[112,148,203,216,279,339,421],"relatively":[113,296],"unaffected":[114,297],"state.":[118,284],"When":[119],"cases":[120],"senile":[122,232,256,398],"dementia":[123],"compared":[125],"controls":[127],"(matched":[128],"respect":[130],"cause":[133],"death)":[135],"activity":[137,166,172],"(the":[140],"cholinergic":[144,200],"neurons)":[145],"appears":[146,195,321,337],"reduced":[149,175,254],"cerebral":[152,428],"cortex.":[153],"This":[154,285,335],"is":[155,286,326,392],"preliminary":[157],"finding,":[158],"although":[159],"correlation":[161],"was":[162,173],"indicated":[163],"between":[164],"'senile'":[168],"morphological":[169],"changes,":[170],"markedly":[174],"only":[177],"3":[178],"brains.":[179],"However,":[180],"despite":[181],"inconsistencies":[182],"literature":[185],"(Karczmar,":[186],"1975)":[187],"at":[188],"least":[189],"one":[190],"pharmacological":[191],"study":[192],"humans":[194],"show":[197],"that":[198,322,349,379,407],"system":[201],"may":[202,215,420],"involved":[204],"age-related":[206],"memory":[207],"degeneration":[208],"(Drachman":[209],"Leavitt,":[211],"1974).":[212],"Cholinergic":[213],"abnormal":[217],"abiotrophies":[221],"examined":[222],"(Huntington's":[223],"chorea,":[224],"motor":[225],"neuron":[226],"disease":[227],"mixed":[229],"vascular":[230],"dementia).":[233],"neuronin":[236,293,362],"S-5":[237],"(identical":[238],"most":[240],"respects":[241],"acidic":[245,272],"neuronal":[246],"14-3-2":[248],"antigen":[250],"alpha)":[251],"not":[253],"dementia.":[257],"The":[258],"decarboxylase":[262],"(GAD":[263],"AAD)":[265],"another":[270],"S-6)":[276],"appear":[277],"affected":[280],"remarkable":[287],"because":[288],"GAD":[289],"and,":[290],"particular,":[292],"S6,":[294],"are":[295,359,364],"autolysis.":[300],"As":[301],"judged":[302],"extraneural":[308],"systems":[309],"regulated":[311],"blood":[313,429],"oxygen":[315],"supply":[316],"it":[320],"terminal":[323,381,405,425],"'cerebral":[324],"hypoxia'":[325],"responsible":[327],"for":[328,400],"depletion":[330],"constituents.":[334],"effect":[336,402],"particularly":[340,393],"marked":[341],"deep":[343],"grey":[344],"matter.":[345],"non-demented":[347],"die":[350],"bronchopneumonia,":[352],"areas":[354],"cortex":[357,375],"depleted":[360],"S-6":[363],"consistent":[365],"pattern":[368],"'selective":[371],"vulnerability'":[372],"hypoxia,":[377],"suggesting":[378],"can":[383],"also":[384],"affect":[385],"neocortex.":[387],"If":[388],"so,":[389],"then":[390],"relevant":[394],"studies":[396],"dementia,":[399],"bronchopneumonia":[406],"so":[408],"often":[409],"occurs":[410],"(and":[414],"abiotrophies)":[419],"exacerbated":[422],"reduction":[426],"flow...":[430]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}