{"id":"https://openalex.org/W2010105020","doi":"https://doi.org/10.3390/molecules14010068","title":"Enaminones as Building Blocks in Heterocyclic Syntheses: Reinvestigating the Product Structures of Enaminones with Malononitrile. A Novel Route to 6-Substituted-3-Oxo-2,3-Dihydropyridazine-4-Carboxylic Acids","display_name":"Enaminones as Building Blocks in Heterocyclic Syntheses: Reinvestigating the Product Structures of Enaminones with Malononitrile. A Novel Route to 6-Substituted-3-Oxo-2,3-Dihydropyridazine-4-Carboxylic Acids","publication_year":2008,"publication_date":"2008-12-29","ids":{"openalex":"https://openalex.org/W2010105020","doi":"https://doi.org/10.3390/molecules14010068","mag":"2010105020","pmid":"https://pubmed.ncbi.nlm.nih.gov/19127238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6254057"},"language":"en","primary_location":{"id":"doi:10.3390/molecules14010068","doi":"https://doi.org/10.3390/molecules14010068","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules14010068","pdf_url":"https://www.mdpi.com/1420-3049/14/1/68/pdf?version=1403112530","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/14/1/68/pdf?version=1403112530","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109989782","display_name":"Abdulaziz Alnajjar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143601524","display_name":"Public Authority for Applied Education and Training","ror":"https://ror.org/024242h31","country_code":"KW","type":"education","lineage":["https://openalex.org/I143601524"]},{"id":"https://openalex.org/I4400573285","display_name":"College of Technological Studies","ror":"https://ror.org/00hwfn059","country_code":"KW","type":"education","lineage":["https://openalex.org/I4400573285"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Abdul-Aziz Alnajjar","raw_affiliation_strings":["Applied Science Department, College of Technological Studies, Public Authority for Applied Education and Training, P. O. Box 42325 Safat, 70654, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Science Department, College of Technological Studies, Public Authority for Applied Education and Training, P. O. Box 42325 Safat, 70654, Kuwait","institution_ids":["https://openalex.org/I143601524","https://openalex.org/I4400573285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087304953","display_name":"Mervat Mohammed Abdelkhalik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143601524","display_name":"Public Authority for Applied Education and Training","ror":"https://ror.org/024242h31","country_code":"KW","type":"education","lineage":["https://openalex.org/I143601524"]},{"id":"https://openalex.org/I4400573285","display_name":"College of Technological Studies","ror":"https://ror.org/00hwfn059","country_code":"KW","type":"education","lineage":["https://openalex.org/I4400573285"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Mervat Mohammed Abdelkhalik","raw_affiliation_strings":["Applied Science Department, College of Technological Studies, Public Authority for Applied Education and Training, P. O. Box 42325 Safat, 70654, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Science Department, College of Technological Studies, Public Authority for Applied Education and Training, P. O. Box 42325 Safat, 70654, Kuwait","institution_ids":["https://openalex.org/I143601524","https://openalex.org/I4400573285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110606717","display_name":"Amal Al\u2010Enezi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143601524","display_name":"Public Authority for Applied Education and Training","ror":"https://ror.org/024242h31","country_code":"KW","type":"education","lineage":["https://openalex.org/I143601524"]},{"id":"https://openalex.org/I4400573285","display_name":"College of Technological Studies","ror":"https://ror.org/00hwfn059","country_code":"KW","type":"education","lineage":["https://openalex.org/I4400573285"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Amal Al-Enezi","raw_affiliation_strings":["Applied Science Department, College of Technological Studies, Public Authority for Applied Education and Training, P. O. Box 42325 Safat, 70654, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Science Department, College of Technological Studies, Public Authority for Applied Education and Training, P. O. Box 42325 Safat, 70654, Kuwait","institution_ids":["https://openalex.org/I143601524","https://openalex.org/I4400573285"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087854243","display_name":"Mohamed Hilmy Elnagdi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Mohamed Hilmy Elnagdi","raw_affiliation_strings":["Chemistry Department, Kuwait University, P.O. Box 5969 Safat, 13060, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Kuwait University, P.O. Box 5969 Safat, 13060, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087304953"],"corresponding_institution_ids":["https://openalex.org/I143601524","https://openalex.org/I4400573285"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":1.1026,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.7318593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"68","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enaminones","display_name":"enaminones","score":0.9980000257492065},{"id":"https://openalex.org/keywords/malononitrile","display_name":"malononitrile","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nitrous-acid","display_name":"nitrous acid","score":0.8320000171661377},{"id":"https://openalex.org/keywords/benzenediazonium-chloride","display_name":"benzenediazonium chloride","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2780513484","wikidata":"https://www.wikidata.org/wiki/Q419572","display_name":"Malononitrile","level":3,"score":0.9538635015487671},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8438384532928467},{"id":"https://openalex.org/C2781462491","wikidata":"https://www.wikidata.org/wiki/Q410234","display_name":"Piperidine","level":2,"score":0.7574677467346191},{"id":"https://openalex.org/C2779074116","wikidata":"https://www.wikidata.org/wiki/Q134856","display_name":"Carboxylic acid","level":2,"score":0.6920856237411499},{"id":"https://openalex.org/C2776942435","wikidata":"https://www.wikidata.org/wiki/Q409171","display_name":"Thionyl chloride","level":3,"score":0.6118782758712769},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.5026438236236572},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.4612428545951843},{"id":"https://openalex.org/C2776419827","wikidata":"https://www.wikidata.org/wiki/Q211891","display_name":"Nitrous acid","level":2,"score":0.4325537383556366},{"id":"https://openalex.org/C2781212610","wikidata":"https://www.wikidata.org/wiki/Q39094","display_name":"Dihydropyridine","level":3,"score":0.41281700134277344},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.36656010150909424},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3545762300491333},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1554061472415924},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.05921578407287598}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/molecules14010068","doi":"https://doi.org/10.3390/molecules14010068","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules14010068","pdf_url":"https://www.mdpi.com/1420-3049/14/1/68/pdf?version=1403112530","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5238538","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6254057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6254057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6254057","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:19127238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19127238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dcdad2727be740a6a2bc55e9e827fae6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dcdad2727be740a6a2bc55e9e827fae6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 14, Iss 1, Pp 68-77 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules14010068","doi":"https://doi.org/10.3390/molecules14010068","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules14010068","pdf_url":"https://www.mdpi.com/1420-3049/14/1/68/pdf?version=1403112530","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327955","display_name":"Public Authority for Applied Education and Training","ror":"https://ror.org/024242h31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010105020.pdf","grobid_xml":"https://content.openalex.org/works/W2010105020.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1970547340","https://openalex.org/W1979547872","https://openalex.org/W2014902216","https://openalex.org/W2018095341","https://openalex.org/W2031780387","https://openalex.org/W2038852775","https://openalex.org/W2059911260","https://openalex.org/W2086936606","https://openalex.org/W2095103100","https://openalex.org/W2135676641","https://openalex.org/W2949564464","https://openalex.org/W2949805206","https://openalex.org/W2950247446","https://openalex.org/W2950404034","https://openalex.org/W2950626137","https://openalex.org/W2950679373","https://openalex.org/W2951769102","https://openalex.org/W2951960684","https://openalex.org/W2952730809","https://openalex.org/W6764514986"],"related_works":["https://openalex.org/W2110619332","https://openalex.org/W2111852401","https://openalex.org/W2951644288","https://openalex.org/W2951960684","https://openalex.org/W2049491025","https://openalex.org/W2147756358","https://openalex.org/W1966120089","https://openalex.org/W2274532917","https://openalex.org/W1979873390","https://openalex.org/W2952409696"],"abstract_inverted_index":{"The":[0],"reported":[1],"structures":[2],"of":[3,6,24],"reaction":[4],"products":[5],"enaminones":[7],"with":[8,27,31],"malononitrile":[9],"in":[10,48,52],"ethanolic":[11],"piperidine":[12],"are":[13,38],"revised.":[14],"A":[15],"novel":[16],"route":[17],"to":[18,40],"2,3-dihydropyridazine-4-carboxylic":[19],"acids":[20],"4a-c":[21],"via":[22],"reactions":[23],"2-cyano-5-(dimethylamino)-5-arylpenta-2,4-dienamides":[25],"8a-c":[26,37],"nitrous":[28],"acid":[29,42],"or":[30],"benzenediazonium":[32],"chloride":[33],"is":[34],"reported.":[35],"Compounds":[36],"converted":[39],"1,2-dihydropyridine-3-carboxylic":[41],"and":[43,51],"1,2-dihydropyridine-3-carbonitrile":[44],"derivatives":[45],"upon":[46],"reflux":[47],"EtOH/":[49],"HCl":[50],"AcOH.":[53]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
