{"id":"https://openalex.org/W2010097418","doi":"https://doi.org/10.1016/j.cdp.2003.07.002","title":"Induction of cell cycle arrest and apoptosis in human cervix carcinoma cells during therapy by cisplatin","display_name":"Induction of cell cycle arrest and apoptosis in human cervix carcinoma cells during therapy by cisplatin","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2010097418","doi":"https://doi.org/10.1016/j.cdp.2003.07.002","mag":"2010097418","pmid":"https://pubmed.ncbi.nlm.nih.gov/14642557"},"language":"en","primary_location":{"id":"doi:10.1016/j.cdp.2003.07.002","doi":"https://doi.org/10.1016/j.cdp.2003.07.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cdp.2003.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S197761248","display_name":"Cancer Detection and Prevention","issn_l":"0361-090X","issn":["0361-090X","1525-1500","1873-443X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Detection and Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017962270","display_name":"Daniela Schloffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Daniela Schloffer","raw_affiliation_strings":["Cell Cycle Regulation Group, Institute of Cancer Research, Faculty of Medicine, University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Cycle Regulation Group, Institute of Cancer Research, Faculty of Medicine, University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032595342","display_name":"Marcel Hork\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Marcel Horky","raw_affiliation_strings":["Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033162117","display_name":"Vladim\u00edr Kotala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Vladimir Kotala","raw_affiliation_strings":["Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108585219","display_name":"J\u00f3zefa W\u0119sierska\u2010G\u0105dek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"J\u00f3zefa W\u0229sierska-Ga\u0327dek","raw_affiliation_strings":["Cell Cycle Regulation Group, Institute of Cancer Research, Faculty of Medicine, University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Cycle Regulation Group, Institute of Cancer Research, Faculty of Medicine, University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108585219"],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":null,"apc_paid":null,"fwci":0.4714,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.54227548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"27","issue":"6","first_page":"481","last_page":"493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.06759999692440033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":1.0},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.953000009059906},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.8180000185966492},{"id":"https://openalex.org/keywords/chromatin-fragmentation","display_name":"chromatin fragmentation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8597785234451294},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7204232215881348},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.605857789516449},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5285626649856567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5276602506637573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5232245326042175},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.44962769746780396},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4458697438240051},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35437917709350586},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3308897614479065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19423553347587585},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.193450927734375},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11034536361694336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.045665442943573}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002466","descriptor_name":"Cell Nucleolus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cdp.2003.07.002","doi":"https://doi.org/10.1016/j.cdp.2003.07.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cdp.2003.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S197761248","display_name":"Cancer Detection and Prevention","issn_l":"0361-090X","issn":["0361-090X","1525-1500","1873-443X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Detection and Prevention","raw_type":"journal-article"},{"id":"pmid:14642557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14642557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer detection and prevention","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321960","display_name":"Herzfelder'sche Familienstiftung","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W262542879","https://openalex.org/W1509012393","https://openalex.org/W1530667298","https://openalex.org/W1589781741","https://openalex.org/W1741860215","https://openalex.org/W1920284083","https://openalex.org/W1965260678","https://openalex.org/W1969093459","https://openalex.org/W1976453250","https://openalex.org/W1977379434","https://openalex.org/W2004877384","https://openalex.org/W2018646351","https://openalex.org/W2022631460","https://openalex.org/W2025963365","https://openalex.org/W2041206676","https://openalex.org/W2043148454","https://openalex.org/W2054854596","https://openalex.org/W2059977695","https://openalex.org/W2067572608","https://openalex.org/W2070461153","https://openalex.org/W2077623099","https://openalex.org/W2080883315","https://openalex.org/W2082558713","https://openalex.org/W2102882456","https://openalex.org/W2133427241","https://openalex.org/W2144701362","https://openalex.org/W2150335546","https://openalex.org/W2159091225","https://openalex.org/W2165382714","https://openalex.org/W2402301512","https://openalex.org/W2470223656","https://openalex.org/W4230623441","https://openalex.org/W4230712136","https://openalex.org/W6631836244","https://openalex.org/W6635209757"],"related_works":["https://openalex.org/W2747339335","https://openalex.org/W2023053165","https://openalex.org/W2351196165","https://openalex.org/W1977860891","https://openalex.org/W2397873468","https://openalex.org/W7100471158","https://openalex.org/W2388658149","https://openalex.org/W1920284083","https://openalex.org/W2372244207","https://openalex.org/W2186559937"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}