{"id":"https://openalex.org/W2010095758","doi":"https://doi.org/10.1056/nejmc055540","title":"LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs","display_name":"LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs","publication_year":2006,"publication_date":"2006-01-25","ids":{"openalex":"https://openalex.org/W2010095758","doi":"https://doi.org/10.1056/nejmc055540","mag":"2010095758","pmid":"https://pubmed.ncbi.nlm.nih.gov/16436781"},"language":"en","primary_location":{"id":"doi:10.1056/nejmc055540","doi":"https://doi.org/10.1056/nejmc055540","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmc055540","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMc055540?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMc055540?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072972205","display_name":"Suzanne Lesage","orcid":"https://orcid.org/0000-0003-4158-2601","observed_orcids":["https://orcid.org/0000-0003-4158-2601"]},"institutions":[{"id":"https://openalex.org/I4405275326","display_name":"Physiopathologie des Comportements","ror":"https://ror.org/03ct18y90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405275326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Suzanne Lesage","raw_affiliation_strings":["Neurologie et th\u00e9rapeutique exp\u00e9rimentale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurologie et th\u00e9rapeutique exp\u00e9rimentale","institution_ids":["https://openalex.org/I4405275326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027293126","display_name":"Alexandra D\u00fcrr","orcid":"https://orcid.org/0000-0002-8921-7104","observed_orcids":["https://orcid.org/0000-0002-8921-7104"]},"institutions":[{"id":"https://openalex.org/I4405275326","display_name":"Physiopathologie des Comportements","ror":"https://ror.org/03ct18y90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405275326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandra D\u00fcrr","raw_affiliation_strings":["Neurologie et th\u00e9rapeutique exp\u00e9rimentale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurologie et th\u00e9rapeutique exp\u00e9rimentale","institution_ids":["https://openalex.org/I4405275326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041801802","display_name":"M\u00e9riem Tazir","orcid":"https://orcid.org/0000-0003-1735-7471","observed_orcids":["https://orcid.org/0000-0003-1735-7471"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meriem Tazir","raw_affiliation_strings":["Service de Neurologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013051631","display_name":"Ebba Lohmann","orcid":"https://orcid.org/0000-0001-8695-7919","observed_orcids":["https://orcid.org/0000-0001-8695-7919"]},"institutions":[{"id":"https://openalex.org/I4405275326","display_name":"Physiopathologie des Comportements","ror":"https://ror.org/03ct18y90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405275326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ebba Lohmann","raw_affiliation_strings":["Neurologie et th\u00e9rapeutique exp\u00e9rimentale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurologie et th\u00e9rapeutique exp\u00e9rimentale","institution_ids":["https://openalex.org/I4405275326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044254335","display_name":"Anne\u2010Louise Leutenegger","orcid":"https://orcid.org/0000-0002-1302-4357","observed_orcids":["https://orcid.org/0000-0002-1302-4357"]},"institutions":[{"id":"https://openalex.org/I4405275326","display_name":"Physiopathologie des Comportements","ror":"https://ror.org/03ct18y90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405275326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Louise Leutenegger","raw_affiliation_strings":["Neurologie et th\u00e9rapeutique exp\u00e9rimentale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurologie et th\u00e9rapeutique exp\u00e9rimentale","institution_ids":["https://openalex.org/I4405275326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006044613","display_name":"Sabine Janin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275326","display_name":"Physiopathologie des Comportements","ror":"https://ror.org/03ct18y90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405275326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sabine Janin","raw_affiliation_strings":["Neurologie et th\u00e9rapeutique exp\u00e9rimentale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurologie et th\u00e9rapeutique exp\u00e9rimentale","institution_ids":["https://openalex.org/I4405275326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113635827","display_name":"Pierre Pollak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Pollak","raw_affiliation_strings":["Neurosciences pr\u00e9cliniques"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosciences pr\u00e9cliniques","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027489586","display_name":"Alexis Brice","orcid":"https://orcid.org/0000-0002-0941-3990","observed_orcids":["https://orcid.org/0000-0002-0941-3990"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405275326","display_name":"Physiopathologie des Comportements","ror":"https://ror.org/03ct18y90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4405264447","https://openalex.org/I4405275326"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexis Brice","raw_affiliation_strings":["CHU Piti\u00e9-Salp\u00eatri\u00e8re [AP-HP]","Neurologie et th\u00e9rapeutique exp\u00e9rimentale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Piti\u00e9-Salp\u00eatri\u00e8re [AP-HP]","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"raw_affiliation_string":"Neurologie et th\u00e9rapeutique exp\u00e9rimentale","institution_ids":["https://openalex.org/I4405275326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":42.5391,"has_fulltext":true,"cited_by_count":554,"citation_normalized_percentile":{"value":0.99940999,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"354","issue":"4","first_page":"422","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/g2019s-mutation","display_name":"G2019S mutation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6710000038146973},{"id":"https://openalex.org/keywords/familial-parkinson-s-disease","display_name":"familial Parkinson's disease","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8470911979675293},{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.7468910217285156},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7289363741874695},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5358119606971741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22773626446723938}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000352","descriptor_name":"Africa, Northern","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018912","descriptor_name":"Arabs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1056/nejmc055540","doi":"https://doi.org/10.1056/nejmc055540","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmc055540","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMc055540?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:16436781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16436781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Letter"},{"id":"pmh:oai:HAL:hal-00221453v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00221453","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"New England Journal of Medicine, 2006, 354 (4), pp.422-3. &#x27E8;10.1056/NEJMc055540&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1056/nejmc055540","doi":"https://doi.org/10.1056/nejmc055540","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmc055540","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMc055540?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010095758.pdf","grobid_xml":"https://content.openalex.org/works/W2010095758.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W2008886854","https://openalex.org/W2021097923","https://openalex.org/W2069221714","https://openalex.org/W2081139491","https://openalex.org/W2098152756","https://openalex.org/W2100894616","https://openalex.org/W2103306563","https://openalex.org/W2317804643"],"related_works":["https://openalex.org/W1989215691","https://openalex.org/W4401845570","https://openalex.org/W4397019229","https://openalex.org/W2019456102","https://openalex.org/W1560381557","https://openalex.org/W2000902364","https://openalex.org/W2330445375","https://openalex.org/W2120680943","https://openalex.org/W2061509935","https://openalex.org/W7096877554"],"abstract_inverted_index":{"To":[0],"the":[1,15,21],"Editor:":[2],"Parkinson's":[3],"disease":[4],"is":[5],"characterized":[6],"by":[7,14],"resting":[8],"tremor,":[9],"rigidity,":[10],"and":[11],"bradykinesia":[12],"caused":[13],"loss":[16],"of":[17],"dopaminergic":[18],"neurons":[19],"in":[20],"substantia":[22],"nigra,":[23],"a":[24],"good":[25],"response":[26],"to":[27],"levodopa,":[28],"an...":[29]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
