{"id":"https://openalex.org/W2010095385","doi":"https://doi.org/10.1157/13110209","title":"Impacto de la reducci\u00f3n de dosis de estavudina en su perfil de eficacia/seguridad en pacientes con infecci\u00f3n por el virus de la inmunodeficiencia humana inmunol\u00f3gica y virol\u00f3gicamente estables","display_name":"Impacto de la reducci\u00f3n de dosis de estavudina en su perfil de eficacia/seguridad en pacientes con infecci\u00f3n por el virus de la inmunodeficiencia humana inmunol\u00f3gica y virol\u00f3gicamente estables","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W2010095385","doi":"https://doi.org/10.1157/13110209","mag":"2010095385","pmid":"https://pubmed.ncbi.nlm.nih.gov/17915129"},"language":"es","primary_location":{"id":"doi:10.1157/13110209","doi":"https://doi.org/10.1157/13110209","is_oa":false,"landing_page_url":"https://doi.org/10.1157/13110209","pdf_url":null,"source":{"id":"https://openalex.org/S207544546","display_name":"Medicina Cl\u00ednica","issn_l":"0025-7753","issn":["0025-7753","1575-4677","1578-8989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina Cl\u00ednica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023915997","display_name":"Enric Pedrol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111059","display_name":"Hospital General de Granollers","ror":"https://ror.org/0190kj665","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210111059"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Enric Pedrol","raw_affiliation_strings":["Unitat de Malalties Infeccioses-VIH, Hospital General de Granollers, Granollers, Barcelona, Espa\u00f1a. epedrol@fhag.es","Unitat de Malalties Infeccioses-VIH. Hospital General de Granollers. Granollers. Barcelona. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Malalties Infeccioses-VIH, Hospital General de Granollers, Granollers, Barcelona, Espa\u00f1a. epedrol@fhag.es","institution_ids":["https://openalex.org/I4210111059"]},{"raw_affiliation_string":"Unitat de Malalties Infeccioses-VIH. Hospital General de Granollers. Granollers. Barcelona. Espa\u00f1a","institution_ids":["https://openalex.org/I4210111059"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Teodoro Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105637","display_name":"Hospital Universitario Puerta de Hierro Majadahonda","ror":"https://ror.org/01e57nb43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210105637","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teodoro Mart\u00edn","raw_affiliation_strings":["Unidad VIH. Hospital Puerta de Hierro. Madrid. Espa\u00f1a","Unidad VIH. Hospital Puerta de Hierro. Madrid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad VIH. Hospital Puerta de Hierro. Madrid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210105637"]},{"raw_affiliation_string":"Unidad VIH. Hospital Puerta de Hierro. Madrid","institution_ids":["https://openalex.org/I4210105637"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Miguel Angel del Pozo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157802","display_name":"Hospital Cl\u00ednico Universitario de Valladolid","ror":"https://ror.org/04fffmj41","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210157802"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Angel del Pozo","raw_affiliation_strings":["Unidad VIH. Hospital Cl\u00ednico Universitario de Valladolid. Valladolid. Espa\u00f1a","Unidad VIH. Hospital Cl\u00ednico Universitario de Valladolid. Valladolid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad VIH. Hospital Cl\u00ednico Universitario de Valladolid. Valladolid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210157802"]},{"raw_affiliation_string":"Unidad VIH. Hospital Cl\u00ednico Universitario de Valladolid. Valladolid","institution_ids":["https://openalex.org/I4210157802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076780201","display_name":"Juan Flores","orcid":"https://orcid.org/0000-0001-9385-9559","observed_orcids":["https://orcid.org/0000-0001-9385-9559"]},"institutions":[{"id":"https://openalex.org/I4210119293","display_name":"Hospital Arnau de Vilanova","ror":"https://ror.org/02s7fkk92","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210119293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Flores","raw_affiliation_strings":["Unidad VIH. Hospital Arnau de Vilanova. Valencia. Espa\u00f1a","Unidad VIH. Hospital Arnau de Vilanova. Valencia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad VIH. Hospital Arnau de Vilanova. Valencia. Espa\u00f1a","institution_ids":["https://openalex.org/I4210119293"]},{"raw_affiliation_string":"Unidad VIH. Hospital Arnau de Vilanova. Valencia","institution_ids":["https://openalex.org/I4210119293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079555852","display_name":"Jos\u00e9 Sanz","orcid":"https://orcid.org/0000-0003-3180-184X","observed_orcids":["https://orcid.org/0000-0003-3180-184X"]},"institutions":[{"id":"https://openalex.org/I4210106572","display_name":"Hospital Universitario Pr\u00edncipe de Asturias","ror":"https://ror.org/01az6dv73","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210106572","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Sanz","raw_affiliation_strings":["Unidad VIH. Hospital Pr\u00edncipe de Asturias. Alcal\u00e1 de Henares. Madrid. Espa\u00f1a","Unidad VIH. Hospital Pr\u00edncipe de Asturias. Alcal\u00e1 de Henares. Madrid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad VIH. Hospital Pr\u00edncipe de Asturias. Alcal\u00e1 de Henares. Madrid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210106572"]},{"raw_affiliation_string":"Unidad VIH. Hospital Pr\u00edncipe de Asturias. Alcal\u00e1 de Henares. Madrid","institution_ids":["https://openalex.org/I4210106572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108084203","display_name":"Jose Antonio Carton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133994","display_name":"Hospital Universitario Central de Asturias","ror":"https://ror.org/03v85ar63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210133994","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A. Cart\u00f3n","raw_affiliation_strings":["Unidad VIH. Hospital Central de Asturias. Oviedo. Asturias. Espa\u00f1a","Unidad VIH. Hospital Central de Asturias. Oviedo. Asturias"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad VIH. Hospital Central de Asturias. Oviedo. Asturias. Espa\u00f1a","institution_ids":["https://openalex.org/I4210133994"]},{"raw_affiliation_string":"Unidad VIH. Hospital Central de Asturias. Oviedo. Asturias","institution_ids":["https://openalex.org/I4210133994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109248742","display_name":"Juan Jos\u00e9 Jusdado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158692","display_name":"Hospital Universitario Severo Ochoa","ror":"https://ror.org/05s3h8004","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210158692"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan-Jos\u00e9 Jusdado","raw_affiliation_strings":["Unidad VIH. Hospital Severo Ochoa. Madrid. Espa\u00f1a","Unidad VIH. Hospital Severo Ochoa. Madrid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad VIH. Hospital Severo Ochoa. Madrid. Espa\u00f1a","institution_ids":["https://openalex.org/I4210158692"]},{"raw_affiliation_string":"Unidad VIH. Hospital Severo Ochoa. Madrid","institution_ids":["https://openalex.org/I4210158692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087702556","display_name":"Piedad Arazo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Piedad Arazo","raw_affiliation_strings":["Unidad VIH. Hospital Miguel Servet. Zaragoza. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad VIH. Hospital Miguel Servet. Zaragoza. Espa\u00f1a","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001003748","display_name":"Esteban Ribera","orcid":"https://orcid.org/0000-0002-3752-8808","observed_orcids":["https://orcid.org/0000-0002-3752-8808"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esteve Ribera","raw_affiliation_strings":["Servei de Malalties Infeccioses. Hospital Vall d\u2019Hebron. Barcelona. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servei de Malalties Infeccioses. Hospital Vall d\u2019Hebron. Barcelona. Espa\u00f1a","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041867984","display_name":"Elisabet Deig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111059","display_name":"Hospital General de Granollers","ror":"https://ror.org/0190kj665","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210111059"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elisabet Deig","raw_affiliation_strings":["Unitat de Malalties Infeccioses-VIH. Hospital General de Granollers. Granollers. Barcelona. Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unitat de Malalties Infeccioses-VIH. Hospital General de Granollers. Granollers. Barcelona. Espa\u00f1a","institution_ids":["https://openalex.org/I4210111059"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5023915997"],"corresponding_institution_ids":["https://openalex.org/I4210111059"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.4294,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.64501223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"129","issue":"10","first_page":"361","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stavudine","display_name":"stavudine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lipodystrophy","display_name":"lipodystrophy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.9150000214576721},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8117019534111023},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.48889198899269104}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018119","descriptor_name":"Stavudine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1157/13110209","doi":"https://doi.org/10.1157/13110209","is_oa":false,"landing_page_url":"https://doi.org/10.1157/13110209","pdf_url":null,"source":{"id":"https://openalex.org/S207544546","display_name":"Medicina Cl\u00ednica","issn_l":"0025-7753","issn":["0025-7753","1575-4677","1578-8989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina Cl\u00ednica","raw_type":"journal-article"},{"id":"pmid:17915129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17915129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina clinica","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W22123178","https://openalex.org/W111011746","https://openalex.org/W1978803727","https://openalex.org/W1978902758","https://openalex.org/W1981185527","https://openalex.org/W2004963112","https://openalex.org/W2012228144","https://openalex.org/W2033995953","https://openalex.org/W2034760164","https://openalex.org/W2054306124","https://openalex.org/W2054620412","https://openalex.org/W2056779298","https://openalex.org/W2127970905","https://openalex.org/W2135450624","https://openalex.org/W2330207218","https://openalex.org/W2333399282","https://openalex.org/W2335165509","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2047995333","https://openalex.org/W2012228144","https://openalex.org/W2435567028","https://openalex.org/W2411004043","https://openalex.org/W2530733690","https://openalex.org/W2045935481","https://openalex.org/W2127970905","https://openalex.org/W2168665142","https://openalex.org/W2157808261","https://openalex.org/W2160188566"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}