{"id":"https://openalex.org/W2010089162","doi":"https://doi.org/10.1186/1755-8166-7-s1-p94","title":"Role of TNF \u03b1 in the etiopathogenesis of PCOS: a clinical, biochemical and molecular genetic study","display_name":"Role of TNF \u03b1 in the etiopathogenesis of PCOS: a clinical, biochemical and molecular genetic study","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2010089162","doi":"https://doi.org/10.1186/1755-8166-7-s1-p94","mag":"2010089162"},"language":"en","primary_location":{"id":"doi:10.1186/1755-8166-7-s1-p94","doi":"https://doi.org/10.1186/1755-8166-7-s1-p94","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8166-7-s1-p94","pdf_url":"https://molecularcytogenetics.biomedcentral.com/track/pdf/10.1186/1755-8166-7-S1-P94","source":{"id":"https://openalex.org/S144751283","display_name":"Molecular Cytogenetics","issn_l":"1755-8166","issn":["1755-8166"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cytogenetics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecularcytogenetics.biomedcentral.com/track/pdf/10.1186/1755-8166-7-S1-P94","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111407720","display_name":"Sujatha Thathapudi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sujatha Thathapudi","raw_affiliation_strings":["Vasavi Medical Research Centre, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vasavi Medical Research Centre, Hyderabad, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017763552","display_name":"Vijayalakshmi Kodati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijayalakshmi Kodati","raw_affiliation_strings":["Vasavi Medical Research Centre, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vasavi Medical Research Centre, Hyderabad, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044180738","display_name":"Ahuja Yog RAJ","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahuja Raj","raw_affiliation_strings":["Vasavi Medical Research Centre, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vasavi Medical Research Centre, Hyderabad, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028913716","display_name":"Uma Addepally","orcid":"https://orcid.org/0000-0002-1074-1588","observed_orcids":["https://orcid.org/0000-0002-1074-1588"]},"institutions":[{"id":"https://openalex.org/I10874241","display_name":"Jawaharlal Nehru Technological University, Hyderabad","ror":"https://ror.org/002tchr49","country_code":"IN","type":"education","lineage":["https://openalex.org/I10874241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Uma Addepally","raw_affiliation_strings":["Jawaharlal Nehru Technological University, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jawaharlal Nehru Technological University, Hyderabad, India","institution_ids":["https://openalex.org/I10874241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008107659","display_name":"Anuradha Katragadda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anuradha Katragadda","raw_affiliation_strings":["Anu Test tube baby centre, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anu Test tube baby centre, Hyderabad, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063423633","display_name":"Qurratulain Annie Hasan","orcid":"https://orcid.org/0000-0002-6162-6379","observed_orcids":["https://orcid.org/0000-0002-6162-6379"]},"institutions":[{"id":"https://openalex.org/I4210127887","display_name":"Kamineni Hospitals","ror":"https://ror.org/02r0vmn14","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210127887"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Qurratulain Hasan","raw_affiliation_strings":["Hyderabad Science Society, Hyderabad, India","Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hyderabad Science Society, Hyderabad, India","institution_ids":[]},{"raw_affiliation_string":"Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, India","institution_ids":["https://openalex.org/I4210127887"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111407720"],"corresponding_institution_ids":[],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Suppl 1","first_page":"P94","last_page":"P94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8270000219345093},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.8790000081062317},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.4440000057220459},{"id":"https://openalex.org/keywords/lh-fsh-ratio","display_name":"LH/FSH ratio","score":0.7889999747276306},{"id":"https://openalex.org/keywords/androgen-levels","display_name":"androgen levels","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2780186808","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Hyperandrogenism","level":5,"score":0.9140813946723938},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7131540775299072},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.7024762630462646},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6577911376953125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6170568466186523},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6055241227149963},{"id":"https://openalex.org/C2777693730","wikidata":"https://www.wikidata.org/wiki/Q1140549","display_name":"Abdominal obesity","level":4,"score":0.5698440074920654},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.5024349689483643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4487904906272888},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.41450950503349304},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39355072379112244},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3724706768989563},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33484557271003723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.239641010761261},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.17606651782989502},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.13623157143592834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12288084626197815},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10726511478424072}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1755-8166-7-s1-p94","doi":"https://doi.org/10.1186/1755-8166-7-s1-p94","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8166-7-s1-p94","pdf_url":"https://molecularcytogenetics.biomedcentral.com/track/pdf/10.1186/1755-8166-7-S1-P94","source":{"id":"https://openalex.org/S144751283","display_name":"Molecular Cytogenetics","issn_l":"1755-8166","issn":["1755-8166"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cytogenetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4043696","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4043696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cytogenet","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1755-8166-7-s1-p94","doi":"https://doi.org/10.1186/1755-8166-7-s1-p94","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1755-8166-7-s1-p94","pdf_url":"https://molecularcytogenetics.biomedcentral.com/track/pdf/10.1186/1755-8166-7-S1-P94","source":{"id":"https://openalex.org/S144751283","display_name":"Molecular Cytogenetics","issn_l":"1755-8166","issn":["1755-8166"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cytogenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010089162.pdf","grobid_xml":"https://content.openalex.org/works/W2010089162.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2324700743","https://openalex.org/W4200536543","https://openalex.org/W3166330508","https://openalex.org/W1989165558","https://openalex.org/W2139376417","https://openalex.org/W4401211351","https://openalex.org/W2900775796","https://openalex.org/W2759558833","https://openalex.org/W2888140726","https://openalex.org/W7098531392"],"abstract_inverted_index":{"Polycystic":[0],"ovarian":[1],"syndrome":[2],"(PCOS)":[3],"is":[4,26,236],"one":[5],"of":[6,14,20,45,73,101,106,176,228,254],"the":[7,43,70,124,223],"most":[8],"common":[9],"endocrine":[10],"conditions":[11],"affecting":[12],"women":[13,59,67,251],"reproductive":[15],"age":[16,54,71],"with":[17,62,238,252],"a":[18,200,245],"prevalence":[19],"approximately":[21],"5-10":[22],"%":[23],"worldwide.":[24],"PCOS":[25,49,63,80,102,119,125,182,205,239,256],"characterized":[27],"by":[28],"hyperandrogenism,":[29],"irregular":[30],"menstrual":[31],"cycles,":[32],"polycystic":[33],"ovaries,":[34],"insulin":[35],"resistance,":[36],"obesity":[37],"particularly":[38],"abdominal":[39],"phenotype.":[40],"We":[41,163],"evaluated":[42],"role":[44],"TNF":[46,107,148,169,219,232],"\u03b1":[47,170,220,233],"in":[48,69,118,181,185,206,257],"patients":[50],"and":[51,64,85,103,121,138,151,155,173,183,193,215,230,240],"compared":[52,158],"to":[53,75,159,191,213,222,249],"matched":[55],"healthy":[56,66],"controls.":[57,122],"204":[58,65],"clinically":[60],"diagnosed":[61],"controls":[68,160,186],"group":[72],"17":[74],"35":[76],"years":[77],"were":[78,81,112,116],"evaluated.":[79],"subdiveded":[82],"into":[83],"Obese":[84],"lean":[86],"based":[87],"on":[88],"BMI":[89],"(<":[90],"25":[91,95],"or":[92],"\u2264":[93],">\u2265":[94],"kg/m":[96],").":[97],"Clinical,":[98],"biochemical":[99,226],"characteristics":[100],"molecular":[104,247],"study":[105],"alpha":[108],"gene":[109,234],"C850T":[110],"polymorphism":[111,172,235],"studied.":[113],"Significant":[114],"differences":[115],"observed":[117],"phenotypes":[120],"All":[123],"including":[126],"subtypes":[127],"had":[128,145],"elevated":[129,146],"WC,":[130],"W/H,":[131],"Fasting":[132],"Insulin,":[133],"HOMA-IR,":[134],"LH,":[135],"LH/FSH,":[136],"TG,":[137],"decreased":[139],"HDL":[140],"than":[141],"Controls":[142],"(P<0.0001).":[143],"Patients":[144],"serum":[147],"\u03b1,":[149],"Free":[150],"Total":[152],"testosterone,":[153],"Androstenedione":[154],"DHEA":[156],"when":[157],"(P":[161],"<0.05).":[162],"have":[164],"demonstrated":[165],"an":[166],"association":[167],"between":[168],"\u2013C850T":[171,231],"PCOS.":[174],"Frequency":[175],"T":[177],"allele":[178],"was":[179],"93.5%":[180],"73.5%":[184],"(OR":[187,209],"5.1863,":[188],"CI":[189,211],"3.2893":[190],"8.1773":[192],"P":[194,216],"value":[195,217],"<0.0001).":[196,218],"TT":[197],"genotype":[198],"confers":[199],"fivefold":[201],"high":[202],"risk":[203,253],"for":[204],"our":[207,258],"population":[208],"5.7,":[210],"3.4673":[212],"9.3724":[214],"contributes":[221],"clinical":[224],",":[225],"manifestations":[227],"PCOS,":[229],"associated":[237],"could":[241],"be":[242],"used":[243],"as":[244],"relevant":[246],"marker":[248],"identify":[250],"developing":[255],"population.":[259]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}