{"id":"https://openalex.org/W2010062825","doi":"https://doi.org/10.1371/journal.pone.0074050","title":"Impaired Cardiac SIRT1 Activity by Carbonyl Stress Contributes to Aging-Related Ischemic Intolerance","display_name":"Impaired Cardiac SIRT1 Activity by Carbonyl Stress Contributes to Aging-Related Ischemic Intolerance","publication_year":2013,"publication_date":"2013-09-10","ids":{"openalex":"https://openalex.org/W2010062825","doi":"https://doi.org/10.1371/journal.pone.0074050","mag":"2010062825","pmid":"https://pubmed.ncbi.nlm.nih.gov/24040162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3769351"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0074050","doi":"https://doi.org/10.1371/journal.pone.0074050","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074050","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074050&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074050&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101850709","display_name":"Chunhu Gu","orcid":"https://orcid.org/0000-0002-2709-3142","observed_orcids":["https://orcid.org/0000-0002-2709-3142"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhu Gu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005895228","display_name":"Yuan Xing","orcid":"https://orcid.org/0000-0002-1596-1862","observed_orcids":["https://orcid.org/0000-0002-1596-1862"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Xing","raw_affiliation_strings":["Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Jiang","raw_affiliation_strings":["Department of Plastics and Burns, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastics and Burns, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012304722","display_name":"Mai Chen","orcid":"https://orcid.org/0009-0005-0143-0701","observed_orcids":["https://orcid.org/0009-0005-0143-0701"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mai Chen","raw_affiliation_strings":["Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069404017","display_name":"Ming Guo Xu","orcid":"https://orcid.org/0000-0001-5234-2203","observed_orcids":["https://orcid.org/0000-0001-5234-2203"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Xu","raw_affiliation_strings":["Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617686","display_name":"Yue Yin","orcid":"https://orcid.org/0000-0002-9312-2415","observed_orcids":["https://orcid.org/0000-0002-9312-2415"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Yin","raw_affiliation_strings":["Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369755","display_name":"Chen Li","orcid":"https://orcid.org/0000-0001-5385-6249","observed_orcids":["https://orcid.org/0000-0001-5385-6249","https://orcid.org/0009-0002-8498-0562","https://orcid.org/0009-0007-2357-644X"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Li","raw_affiliation_strings":["Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101511884","display_name":"Zheng Yang","orcid":"https://orcid.org/0000-0002-7000-0466","observed_orcids":["https://orcid.org/0000-0002-7000-0466"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Yang","raw_affiliation_strings":["Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102899286","display_name":"Lu Yu","orcid":"https://orcid.org/0009-0007-9449-8274","observed_orcids":["https://orcid.org/0009-0007-9449-8274"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lu Yu","raw_affiliation_strings":["Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111843643","display_name":"Heng Ma","orcid":"https://orcid.org/0000-0002-1893-0658","observed_orcids":["https://orcid.org/0000-0002-1893-0658"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Heng Ma","raw_affiliation_strings":["Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Dept. of Physiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102899286","https://openalex.org/A5111843643"],"corresponding_institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.2021,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.9488792,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"9","first_page":"e74050","last_page":"e74050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/carbonyl-stress","display_name":"carbonyl stress","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aging-heart","display_name":"aging heart","score":0.6000000238418579},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9739999771118164},{"id":"https://openalex.org/keywords/aldh2","display_name":"ALDH2","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alda-1","display_name":"Alda-1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.875},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.953000009059906},{"id":"https://openalex.org/keywords/cardiac-senescence","display_name":"cardiac senescence","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C3175096","wikidata":"https://www.wikidata.org/wiki/Q2640417","display_name":"ALDH2","level":4,"score":0.878042459487915},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.7872863411903381},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6402838230133057},{"id":"https://openalex.org/C2911203004","wikidata":"https://www.wikidata.org/wiki/Q105409450","display_name":"Protein Carbonylation","level":4,"score":0.5796911120414734},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.5666446089744568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5194860696792603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4966807961463928},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4624055027961731},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.45620107650756836},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4500119090080261},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.44711771607398987},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.4346710443496704},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.43162980675697327},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.41223689913749695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3421599268913269},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.2957083582878113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2898753881454468},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.28269681334495544},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.2688259482383728},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19479122757911682},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.16176366806030273},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.11729279160499573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071396","descriptor_name":"Aldehyde Dehydrogenase, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0074050","doi":"https://doi.org/10.1371/journal.pone.0074050","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074050","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074050&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2764487","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3769351","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24040162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24040162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3769351","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3769351/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.9104","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.9104","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/90/69/pone.0074050.PMC3769351.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0cd369e40acf494e8f59e02eb661c3b1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0cd369e40acf494e8f59e02eb661c3b1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e74050 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0074050","doi":"https://doi.org/10.1371/journal.pone.0074050","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074050","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074050&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5020751849","display_name":null,"funder_award_id":"31201037","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5564996774","display_name":null,"funder_award_id":"81170108","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6009486727","display_name":"G\u86cb\u767d\u5076\u8054\u53d7\u4f53\u6fc0\u91762\u975e\u53d7\u4f53\u4f9d\u8d56\u529f\u80fd\u8c03\u63a7\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\u7684\u7814\u7a76","funder_award_id":"81000062","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8660292455","display_name":null,"funder_award_id":"2011KJXX66","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324530","display_name":"Fourth Military Medical University","ror":"https://ror.org/00ms48f15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010062825.pdf","grobid_xml":"https://content.openalex.org/works/W2010062825.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W86399125","https://openalex.org/W1883493465","https://openalex.org/W1967269670","https://openalex.org/W1973163466","https://openalex.org/W1975621743","https://openalex.org/W1981571637","https://openalex.org/W1981687780","https://openalex.org/W1984301837","https://openalex.org/W2002419953","https://openalex.org/W2008198226","https://openalex.org/W2018682722","https://openalex.org/W2042419649","https://openalex.org/W2055969761","https://openalex.org/W2057099146","https://openalex.org/W2079569030","https://openalex.org/W2087812901","https://openalex.org/W2091579069","https://openalex.org/W2099221133","https://openalex.org/W2100504676","https://openalex.org/W2110966376","https://openalex.org/W2113183122","https://openalex.org/W2118204731","https://openalex.org/W2125797299","https://openalex.org/W2131175598","https://openalex.org/W2135387645","https://openalex.org/W2135711139","https://openalex.org/W2139020323","https://openalex.org/W2144282214","https://openalex.org/W2146627313","https://openalex.org/W2154229481","https://openalex.org/W2157942480","https://openalex.org/W2158124286","https://openalex.org/W2158498082","https://openalex.org/W2169582356","https://openalex.org/W2170684837","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2312456902","https://openalex.org/W965777567","https://openalex.org/W2231679410","https://openalex.org/W2595423647","https://openalex.org/W2042419649","https://openalex.org/W2768944990","https://openalex.org/W3084875178","https://openalex.org/W2069276360","https://openalex.org/W1632314083","https://openalex.org/W2055208928"],"abstract_inverted_index":{"Reactive":[0],"aldehydes":[1,107],"can":[2,267],"initiate":[3],"protein":[4,79],"oxidative":[5],"damage":[6],"which":[7,129],"may":[8],"contribute":[9],"to":[10,18,43,69,95,124,156,189,199,262],"heart":[11,88,261],"senescence.":[12],"Sirtuin":[13],"1":[14],"(SIRT1)":[15],"is":[16,232],"considered":[17],"be":[19,132],"a":[20,53,240,252],"potential":[21],"interventional":[22],"target":[23],"for":[24],"I/R":[25,154,192,206,263],"injury":[26,193],"management":[27],"in":[28,110,164,170,190,194,219,226,234,255],"the":[29,49,144,180,187,256],"elderly.":[30],"We":[31],"hypothesized":[32],"that":[33,86,114,168,243],"aldehyde":[34,73],"mediated":[35],"carbonyl":[36,116,249],"stress":[37,93,231,250],"increases":[38],"susceptibility":[39,258],"of":[40,147,162,176,259],"aged":[41,63,87,165,195,223,260],"hearts":[42,166,172],"ischemia/reperfusion":[44],"(I/R)":[45],"injury,":[46,128],"and":[47,62,78,184],"elucidate":[48],"underlying":[50],"mechanisms":[51],"with":[52,100],"focus":[54],"on":[55,118,149,182],"SIRT1.":[56],"Male":[57],"C57BL/6":[58],"young":[59,171],"(4-6":[60],"mo)":[61,65],"(22-24":[64],"mice":[66,203],"were":[67,81],"subjected":[68],"myocardial":[70,153,205,271],"I/R.":[71],"Cardiac":[72],"dehydrogenase":[74],"(ALDH2),":[75],"SIRT1":[76,102,119,121,141,163,183,246],"activity":[77,98,103,122,161,247],"carbonyls":[80],"assessed.":[82],"Our":[83],"data":[84],"revealed":[85],"exhibited":[89],"increased":[90,257],"endogenous":[91],"aldehyde/carbonyl":[92,230],"due":[94],"impaired":[96,120,244],"ALDH2":[97,265],"concomitant":[99],"blunted":[101],"(P<0.05).":[104,173],"Exogenous":[105],"toxic":[106],"(4-HNE)":[108],"exposure":[109],"isolated":[111],"cardiomyocyte":[112],"verified":[113,210],"aldehyde-induced":[115],"modification":[117],"leading":[123],"worse":[125],"hypoxia/reoxygenation":[126],"(H/R)":[127],"could":[130],"all":[131],"rescued":[133],"by":[134,211,248],"Alda-1":[135,148,177,212],"(ALDH2":[136],"activator)":[137],"(all":[138],"P<0.05).":[139],"However,":[140],"inhibitor":[142],"blocked":[143],"protective":[145],"effect":[146],"H/R":[150],"cardiomyocyte.":[151],"Interestingly,":[152],"leads":[155],"higher":[157],"carbonylation":[158,181],"but":[159,197,224],"lower":[160],"than":[167],"seen":[169],"The":[174],"application":[175],"significantly":[178],"reduced":[179],"markedly":[185],"improved":[186,214],"tolerance":[188],"vivo":[191,221],"hearts,":[196],"failed":[198],"protect":[200],"Sirt1(+/-)":[201,227],"knockout":[202],"against":[204],"injury.":[207,264],"This":[208],"was":[209],"treatment":[213],"postischemic":[215],"contractile":[216],"function":[217],"recovery":[218],"ex":[220],"perfused":[222],"not":[225],"hearts.":[228],"Thus,":[229],"accelerated":[233],"aging":[235],"heart.":[236],"These":[237],"results":[238],"provide":[239],"new":[241],"insight":[242],"cardiac":[245],"plays":[251],"critical":[253],"role":[254],"activation":[266],"restore":[268],"this":[269],"aging-related":[270],"ischemic":[272],"intolerance.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}