{"id":"https://openalex.org/W2010055793","doi":"https://doi.org/10.1001/archinte.1976.03630040082017","title":"Combination Antibiotic Therapy in Staphylococcal Endocarditis","display_name":"Combination Antibiotic Therapy in Staphylococcal Endocarditis","publication_year":1976,"publication_date":"1976-04-01","ids":{"openalex":"https://openalex.org/W2010055793","doi":"https://doi.org/10.1001/archinte.1976.03630040082017","mag":"2010055793","pmid":"https://pubmed.ncbi.nlm.nih.gov/1267557"},"language":"en","primary_location":{"id":"doi:10.1001/archinte.1976.03630040082017","doi":"https://doi.org/10.1001/archinte.1976.03630040082017","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.1976.03630040082017","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020235374","display_name":"Henry W. Murray","orcid":"https://orcid.org/0000-0002-0363-256X","observed_orcids":["https://orcid.org/0000-0002-0363-256X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. W. Murray","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020235374"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":5.4768,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.95145496,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"136","issue":"4","first_page":"480","last_page":"480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcal-endocarditis","display_name":"staphylococcal endocarditis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9470000267028809},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/methicillin","display_name":"methicillin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/methicillin-susceptible-staphylococcus-aureus","display_name":"methicillin-susceptible Staphylococcus aureus","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.7642608880996704},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6836983561515808},{"id":"https://openalex.org/C2993328841","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotic therapy","level":3,"score":0.6320158243179321},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5042694807052612},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.4887697398662567},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4390719532966614},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4167672097682953},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.3064374327659607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16487041115760803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16361895203590393},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11913129687309265},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.042310506105422974}],"mesh":[{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1001/archinte.1976.03630040082017","doi":"https://doi.org/10.1001/archinte.1976.03630040082017","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.1976.03630040082017","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"doi:10.1001/archinte.136.4.480","doi":"https://doi.org/10.1001/archinte.136.4.480","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.136.4.480","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:1267557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1267557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W65113315","https://openalex.org/W89591179","https://openalex.org/W1508212304","https://openalex.org/W1523117069","https://openalex.org/W1966379934","https://openalex.org/W1983301498","https://openalex.org/W1986207892","https://openalex.org/W1987718907","https://openalex.org/W1988802261","https://openalex.org/W1994432625","https://openalex.org/W2009205491","https://openalex.org/W2009618708","https://openalex.org/W2013586403","https://openalex.org/W2018985542","https://openalex.org/W2024883391","https://openalex.org/W2026770760","https://openalex.org/W2040149740","https://openalex.org/W2048710983","https://openalex.org/W2081402615","https://openalex.org/W2171991902","https://openalex.org/W2266342289","https://openalex.org/W2315940187","https://openalex.org/W2317992381","https://openalex.org/W2323707643","https://openalex.org/W2335460732","https://openalex.org/W2414167218","https://openalex.org/W2463384632","https://openalex.org/W2610793288","https://openalex.org/W4248605883","https://openalex.org/W4252842420"],"related_works":["https://openalex.org/W2039063878","https://openalex.org/W1994432625","https://openalex.org/W4242806979","https://openalex.org/W4242636366","https://openalex.org/W7214201748","https://openalex.org/W65113315","https://openalex.org/W1992997531","https://openalex.org/W2026770760","https://openalex.org/W2035921035","https://openalex.org/W2414167218"],"abstract_inverted_index":{"The":[0,127],"well-demonstrated":[1],"in":[2,16,19,44,48,52,81,88,96],"vitro":[3,49],"synergism":[4,51],"of":[5,13,22,32,69,78,91,99,129],"penicillin":[6],"and":[7,39,73],"aminoglycoside":[8],"antibiotics":[9],"against":[10],"various":[11],"groups":[12],"streptococci,1-6and":[14],"their":[15],"vivo":[17,45],"efficacy":[18],"the":[20,30,67,116],"treatment":[21,122],"endocarditis":[23,86,109],"caused":[24,110],"byStreptococcus":[25],"viridansand":[26],"enterococci":[27],"have":[28],"been":[29,64],"subject":[31],"continued":[33],"interest.6-13Importantly,":[34],"Durack":[35],"et":[36],"al8and":[37],"Sande":[38],"Irvin14have":[40],"demonstrated":[41,65],"a":[42,59,106,112],"definite":[43],"correlation":[46,61],"with":[47,54,66,108],"penicillin-aminoglycoside":[50],"animals":[53],"aS":[55],"viridansendocarditis":[56],"model.":[57],"Recently,":[58],"similar":[60],"also":[62],"has":[63],"use":[68],"aStaphylococcus":[70],"aureusendocarditis":[71],"model":[72],"penicillin-gentamicin":[74],"therapy.15The":[75],"clinical":[76,117],"importance":[77],"combination":[79],"therapy":[80],"serious":[82],"infections":[83],"such":[84],"as":[85],"lies":[87],"its":[89,97],"enhancement":[90],"bacterial":[92],"killing,":[93],"and,":[94],"thus,":[95],"prevention":[98],"further":[100],"vital":[101],"tissue":[102],"destruction.":[103],"We":[104],"report":[105],"patient":[107],"by":[111],"methicillin-sensitiveS":[113],"aureusin":[114],"which":[115],"response":[118],"to":[119],"methicillin":[120],"sodium":[121],"alone":[123],"was":[124],"not":[125],"satisfactory.":[126],"addition":[128],"gentamicin":[130],"sulfate":[131]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}