{"id":"https://openalex.org/W2010029246","doi":"https://doi.org/10.1002/bdd.529","title":"In vitro metabolism of ciclesonide in human nasal epithelial cells","display_name":"In vitro metabolism of ciclesonide in human nasal epithelial cells","publication_year":2006,"publication_date":"2006-11-21","ids":{"openalex":"https://openalex.org/W2010029246","doi":"https://doi.org/10.1002/bdd.529","mag":"2010029246","pmid":"https://pubmed.ncbi.nlm.nih.gov/17117454"},"language":"en","primary_location":{"id":"doi:10.1002/bdd.529","doi":"https://doi.org/10.1002/bdd.529","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdd.529","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics & Drug Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038640614","display_name":"Hideyuki Sato","orcid":"https://orcid.org/0000-0002-5155-2003","observed_orcids":["https://orcid.org/0000-0002-5155-2003"]},"institutions":[{"id":"https://openalex.org/I4405268147","display_name":"Teijin Pharma Limited (Japan)","ror":"https://ror.org/001144c36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405268147"]},{"id":"https://openalex.org/I90469020","display_name":"Teijin (Japan)","ror":"https://ror.org/038kxkq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I90469020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideyuki Sato","raw_affiliation_strings":["Teijin Institute for Biomedical Research, Teijin Pharma Limited, Hino, Tokyo, Japan. hid.satou@teijin.co.jp","Teijin Institute for Biomedical Research, Teijin Pharma Limited, Hino, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teijin Institute for Biomedical Research, Teijin Pharma Limited, Hino, Tokyo, Japan. hid.satou@teijin.co.jp","institution_ids":["https://openalex.org/I4405268147","https://openalex.org/I90469020"]},{"raw_affiliation_string":"Teijin Institute for Biomedical Research, Teijin Pharma Limited, Hino, Tokyo, Japan","institution_ids":["https://openalex.org/I4405268147","https://openalex.org/I90469020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109099328","display_name":"Ruediger Nave","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruediger Nave","raw_affiliation_strings":["ALTANA Pharma AG, Konstanz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALTANA Pharma AG, Konstanz, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takashi Nonaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268147","display_name":"Teijin Pharma Limited (Japan)","ror":"https://ror.org/001144c36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405268147"]},{"id":"https://openalex.org/I90469020","display_name":"Teijin (Japan)","ror":"https://ror.org/038kxkq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I90469020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nonaka","raw_affiliation_strings":["Teijin Institute for Biomedical Research, Teijin Pharma Limited, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teijin Institute for Biomedical Research, Teijin Pharma Limited, Tokyo, Japan","institution_ids":["https://openalex.org/I4405268147","https://openalex.org/I90469020"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tsutomu Mochizuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268147","display_name":"Teijin Pharma Limited (Japan)","ror":"https://ror.org/001144c36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405268147"]},{"id":"https://openalex.org/I90469020","display_name":"Teijin (Japan)","ror":"https://ror.org/038kxkq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I90469020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Mochizuki","raw_affiliation_strings":["Teijin Institute for Biomedical Research, Teijin Pharma Limited, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teijin Institute for Biomedical Research, Teijin Pharma Limited, Tokyo, Japan","institution_ids":["https://openalex.org/I4405268147","https://openalex.org/I90469020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025655163","display_name":"Shigehiro Takahama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268147","display_name":"Teijin Pharma Limited (Japan)","ror":"https://ror.org/001144c36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405268147"]},{"id":"https://openalex.org/I90469020","display_name":"Teijin (Japan)","ror":"https://ror.org/038kxkq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I90469020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigehiro Takahama","raw_affiliation_strings":["Teijin Institute for Biomedical Research, Teijin Pharma Limited, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teijin Institute for Biomedical Research, Teijin Pharma Limited, Tokyo, Japan","institution_ids":["https://openalex.org/I4405268147","https://openalex.org/I90469020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113807895","display_name":"Shiro Kondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268147","display_name":"Teijin Pharma Limited (Japan)","ror":"https://ror.org/001144c36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405268147"]},{"id":"https://openalex.org/I90469020","display_name":"Teijin (Japan)","ror":"https://ror.org/038kxkq33","country_code":"JP","type":"company","lineage":["https://openalex.org/I90469020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiro Kondo","raw_affiliation_strings":["Teijin Institute for Biomedical Research, Teijin Pharma Limited, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teijin Institute for Biomedical Research, Teijin Pharma Limited, Tokyo, Japan","institution_ids":["https://openalex.org/I4405268147","https://openalex.org/I90469020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038640614"],"corresponding_institution_ids":["https://openalex.org/I4405268147","https://openalex.org/I90469020"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":2.2163,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.84775194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"28","issue":"1","first_page":"43","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciclesonide","display_name":"ciclesonide","score":1.0},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nasal-epithelial-cells","display_name":"nasal epithelial cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/carboxylesterase","display_name":"carboxylesterase","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cholinesterase","display_name":"cholinesterase","score":0.996999979019165},{"id":"https://openalex.org/keywords/fatty-acid-conjugation","display_name":"fatty acid conjugation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/esterase-inhibitors","display_name":"esterase inhibitors","score":0.7179999947547913},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.7590000033378601},{"id":"https://openalex.org/keywords/glucocorticoid-metabolites","display_name":"glucocorticoid metabolites","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2777588912","wikidata":"https://www.wikidata.org/wiki/Q5119448","display_name":"Ciclesonide","level":4,"score":0.9941723346710205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7329009175300598},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5084061026573181},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5026907920837402},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.45484742522239685},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.4417005181312561},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44029298424720764},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.43109434843063354},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3956409990787506},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3472113013267517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27108263969421387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2461620569229126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1717766523361206},{"id":"https://openalex.org/C2991922776","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Inhaled corticosteroids","level":3,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004951","descriptor_name":"Esterification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018926","descriptor_name":"Anti-Allergic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bdd.529","doi":"https://doi.org/10.1002/bdd.529","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdd.529","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics & Drug Disposition","raw_type":"journal-article"},{"id":"pmid:17117454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17117454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics & drug disposition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326474","display_name":"Teijin Pharma","ror":"https://ror.org/001144c36"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W64064711","https://openalex.org/W1585188087","https://openalex.org/W1973755752","https://openalex.org/W1984622531","https://openalex.org/W1985265092","https://openalex.org/W2004016685","https://openalex.org/W2007422312","https://openalex.org/W2019259561","https://openalex.org/W2019921656","https://openalex.org/W2021754976","https://openalex.org/W2030517083","https://openalex.org/W2043012375","https://openalex.org/W2059349660","https://openalex.org/W2060635084","https://openalex.org/W2068662516","https://openalex.org/W2073100929","https://openalex.org/W2081332878","https://openalex.org/W2089025869","https://openalex.org/W2154299860","https://openalex.org/W2155318134","https://openalex.org/W2161672948","https://openalex.org/W2183913543"],"related_works":["https://openalex.org/W2024349915","https://openalex.org/W2102926338","https://openalex.org/W2147331074","https://openalex.org/W7100367368","https://openalex.org/W2025234257","https://openalex.org/W2110497938","https://openalex.org/W2154942700","https://openalex.org/W2050321519","https://openalex.org/W1984622531","https://openalex.org/W1986507279"],"abstract_inverted_index":{"Ciclesonide,":[0,94],"a":[1],"corticosteroid":[2],"in":[3,33,116,146,200],"development":[4],"for":[5,50,57,65,73,81,89],"allergic":[6],"rhinitis,":[7],"is":[8,19],"converted":[9,186],"to":[10,29,59,91,123,149,187],"the":[11,135,173],"pharmacologically":[12],"active":[13],"metabolite,":[14],"desisobutyryl-ciclesonide":[15],"(des-CIC),":[16],"and":[17,53,96,154,172,191,193],"des-CIC":[18,80,88,95,97,128,143,167,177,188,194],"subsequently":[20],"esterified":[21],"with":[22,45,108,179],"fatty":[23,98,139,168,197],"acids.":[24],"Various":[25],"experiments":[26],"were":[27,43,102,144],"performed":[28],"investigate":[30],"ciclesonide":[31,49,56,72,115,158,183],"metabolism":[32,159],"human":[34],"nasal":[35,40],"epithelial":[36,41],"cells":[37,42],"(HNEC).":[38],"Human":[39],"incubated":[44],"(a)":[46],"0.1":[47],"microM":[48,71,79],"1":[51,78],"h":[52,67,83,151],"medium":[54,86],"without":[55,87],"up":[58,90,148],"24":[60,92,124,150],"h,":[61,75],"(b)":[62],"esterase":[63],"inhibitors":[64,156],"0.5":[66,122],"followed":[68,84],"by":[69,85,104,189],"5":[70],"6":[74,82],"or":[76,161],"(c)":[77],"h.":[93,125],"acid":[99,140,169,198],"conjugate":[100],"concentrations":[101],"determined":[103],"high-performance":[105],"liquid":[106],"chromatography":[107],"tandem":[109],"mass":[110],"spectrometry.":[111],"The":[112,163],"amount":[113],"of":[114,142,166,176],"HNEC":[117,147],"decreased":[118,157,171],"approximately":[119],"93-fold":[120],"from":[121],"In":[126,181],"contrast,":[127],"was":[129,184],"present":[130],"at":[131],"constant":[132],"levels":[133],"throughout":[134],"post-treatment":[136],"period.":[137],"Furthermore,":[138],"conjugates":[141,170],"retained":[145],"post-treatment.":[152],"Carboxylesterase":[153],"cholinesterase":[155],">":[160],"=50%.":[162],"total":[164],"amounts":[165,175],"extracellular":[174],"increased":[178],"time.":[180],"conclusion,":[182],"rapidly":[185],"carboxylesterases":[190],"cholinesterases,":[192],"underwent":[195],"reversible":[196],"conjugation":[199],"HNEC.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}