{"id":"https://openalex.org/W2010016634","doi":"https://doi.org/10.1002/pros.2990170506","title":"Medical management of benign prostatic hyperplasia with androgen suppression","display_name":"Medical management of benign prostatic hyperplasia with androgen suppression","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2010016634","doi":"https://doi.org/10.1002/pros.2990170506","mag":"2010016634","pmid":"https://pubmed.ncbi.nlm.nih.gov/1689170"},"language":"en","primary_location":{"id":"doi:10.1002/pros.2990170506","doi":"https://doi.org/10.1002/pros.2990170506","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.2990170506","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058375255","display_name":"John D. McConnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John D. McConnell","raw_affiliation_strings":["Division of Urology, University of Texas Southwestern Medical Center, Dallas 75235-9031","Division of Urology, The University of Texas Southwestern Medical Center, Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, University of Texas Southwestern Medical Center, Dallas 75235-9031","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Division of Urology, The University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058375255"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":1.2821,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.66666667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"S3","first_page":"49","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":1.0},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/antiandrogen-therapy","display_name":"antiandrogen therapy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/adrenergic-blockade","display_name":"adrenergic blockade","score":0.7979999780654907},{"id":"https://openalex.org/keywords/balloon-dilation","display_name":"balloon dilation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.7139999866485596},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2779322244","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogen","level":4,"score":0.8175598382949829},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7816349864006042},{"id":"https://openalex.org/C2778313021","wikidata":"https://www.wikidata.org/wiki/Q418669","display_name":"Flutamide","level":5,"score":0.6340681314468384},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6076235771179199},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.6069324016571045},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5052705407142639},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.5009942054748535},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.46789491176605225},{"id":"https://openalex.org/C2910016293","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogens","level":5,"score":0.46263402700424194},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4530368745326996},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.44460529088974},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3384801745414734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3378187417984009},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.15213465690612793},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11952278017997742},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0542183518409729}],"mesh":[{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/pros.2990170506","doi":"https://doi.org/10.1002/pros.2990170506","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.2990170506","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:1689170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1689170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate. Supplement","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1458249850","https://openalex.org/W1479893295","https://openalex.org/W1516998426","https://openalex.org/W1570733582","https://openalex.org/W1893052060","https://openalex.org/W1970686652","https://openalex.org/W1976587221","https://openalex.org/W1981050682","https://openalex.org/W1988234821","https://openalex.org/W1989245520","https://openalex.org/W1992103956","https://openalex.org/W2010245636","https://openalex.org/W2016861044","https://openalex.org/W2053915953","https://openalex.org/W2054959480","https://openalex.org/W2059295683","https://openalex.org/W2070633560","https://openalex.org/W2071065069","https://openalex.org/W2092666751","https://openalex.org/W2097655973","https://openalex.org/W2317511325","https://openalex.org/W2318158772","https://openalex.org/W2398132275","https://openalex.org/W2398632629","https://openalex.org/W2399033839","https://openalex.org/W2400783631","https://openalex.org/W2400995295","https://openalex.org/W2404145601","https://openalex.org/W2416218451","https://openalex.org/W2420236118","https://openalex.org/W2435022163","https://openalex.org/W2441534089","https://openalex.org/W2471966035","https://openalex.org/W2728830059","https://openalex.org/W2729975161","https://openalex.org/W4252519024","https://openalex.org/W4376546421"],"related_works":["https://openalex.org/W7144471749","https://openalex.org/W2038661949","https://openalex.org/W2081690958","https://openalex.org/W2463830283","https://openalex.org/W2154343412","https://openalex.org/W2033003427","https://openalex.org/W2072680766","https://openalex.org/W2413925357","https://openalex.org/W2024277250","https://openalex.org/W1999907152"],"abstract_inverted_index":{"Many":[0],"types":[1],"of":[2,20,34,59,69,78,87],"nonsurgical":[3],"therapy,":[4,13],"including":[5],"balloon":[6],"dilation,":[7],"hyperthermia,":[8],"adrenergic":[9],"blockade,":[10],"and":[11,42,50],"hormonal":[12,35],"have":[14,45],"been":[15,28,47],"used":[16,48],"for":[17,37],"the":[18,29,76,84,88],"treatment":[19,36],"benign":[21],"prostatic":[22],"hyperplasia":[23],"(BPH).":[24],"Antiandrogen":[25],"therapy":[26,61],"has":[27],"most":[30],"extensively":[31],"studied":[32],"form":[33],"BPH,":[38],"although":[39],"estrogens,":[40],"antiestrogens,":[41],"antiprolactin":[43],"agents":[44,79],"also":[46],"(Scott":[49],"Coffey:":[51],"Vitam":[52],"Horm":[53],"33:439-465,":[54],"1975).":[55],"The":[56],"theoretical":[57],"basis":[58],"antiandrogen":[60],"will":[62,90],"be":[63,91],"reviewed":[64],"along":[65],"with":[66],"a":[67],"summary":[68],"relevant":[70],"clinical":[71],"trials.":[72],"Recent":[73],"advances":[74],"in":[75],"development":[77],"that":[80],"more":[81],"selectively":[82],"inhibit":[83],"androgen-dependent":[85],"growth":[86],"prostate":[89],"presented.":[92]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}