{"id":"https://openalex.org/W2010011292","doi":"https://doi.org/10.1161/01.str.18.1.52","title":"Regional cerebral blood flow decreases during chronic and acute hyperglycemia.","display_name":"Regional cerebral blood flow decreases during chronic and acute hyperglycemia.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2010011292","doi":"https://doi.org/10.1161/01.str.18.1.52","mag":"2010011292","pmid":"https://pubmed.ncbi.nlm.nih.gov/2949400"},"language":"en","primary_location":{"id":"doi:10.1161/01.str.18.1.52","doi":"https://doi.org/10.1161/01.str.18.1.52","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.str.18.1.52","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.STR.18.1.52","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.STR.18.1.52","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091418235","display_name":"Robert B. Duckrow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R B Duckrow","raw_affiliation_strings":["R B Duckrow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R B Duckrow","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"D C Beard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D C Beard","raw_affiliation_strings":["D C Beard"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D C Beard","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"R W Brennan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R W Brennan","raw_affiliation_strings":["R W Brennan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R W Brennan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0258,"has_fulltext":true,"cited_by_count":158,"citation_normalized_percentile":{"value":0.9646923,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"52","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regional-cerebral-blood-flow","display_name":"regional cerebral blood flow","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chronic-hyperglycemia","display_name":"chronic hyperglycemia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/acute-hyperglycemia","display_name":"acute hyperglycemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hindbrain","display_name":"hindbrain","score":0.5659999847412109},{"id":"https://openalex.org/keywords/forebrain","display_name":"forebrain","score":0.9789999723434448},{"id":"https://openalex.org/keywords/plasma-glucose","display_name":"plasma glucose","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cerebral-autoregulation","display_name":"cerebral autoregulation","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9200009703636169},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.7541554570198059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6750075221061707},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.5509606003761292},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5482240319252014},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5433720946311951},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5355273485183716},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4696962833404541},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.43484681844711304},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3372645080089569},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3307320475578308},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2620531916618347},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000496","descriptor_name":"Alloxan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.str.18.1.52","doi":"https://doi.org/10.1161/01.str.18.1.52","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.str.18.1.52","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.STR.18.1.52","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:2949400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2949400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"},{"id":"mag:3151195042","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/str.18.1.2949400?related-urls=yes&legid=strokeaha%3B18%2F1%2F52","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Stroke","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.str.18.1.52","doi":"https://doi.org/10.1161/01.str.18.1.52","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.str.18.1.52","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.STR.18.1.52","source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010011292.pdf","grobid_xml":"https://content.openalex.org/works/W2010011292.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1804584144","https://openalex.org/W1977226572","https://openalex.org/W1993363009","https://openalex.org/W2011642892","https://openalex.org/W2011812923","https://openalex.org/W2017215079","https://openalex.org/W2017312959","https://openalex.org/W2029427985","https://openalex.org/W2032275769","https://openalex.org/W2047976105","https://openalex.org/W2049163492","https://openalex.org/W2054538906","https://openalex.org/W2055656759","https://openalex.org/W2056017497","https://openalex.org/W2056683749","https://openalex.org/W2064391857","https://openalex.org/W2065407530","https://openalex.org/W2081241089","https://openalex.org/W2091625139","https://openalex.org/W2091779168","https://openalex.org/W2097056802","https://openalex.org/W2098474086","https://openalex.org/W2113478259","https://openalex.org/W2145294053","https://openalex.org/W2153153317","https://openalex.org/W2155088263","https://openalex.org/W2169142949","https://openalex.org/W2314383377","https://openalex.org/W2329210280","https://openalex.org/W2341370789","https://openalex.org/W2417320512","https://openalex.org/W2419118788","https://openalex.org/W4319054001","https://openalex.org/W6698802556"],"related_works":["https://openalex.org/W2153153317","https://openalex.org/W2091601007","https://openalex.org/W2010669703","https://openalex.org/W3150332700","https://openalex.org/W1974790096","https://openalex.org/W2020011655","https://openalex.org/W3151242502","https://openalex.org/W2136662208","https://openalex.org/W2154265357","https://openalex.org/W69216849"],"abstract_inverted_index":{"The":[0,49],"presence":[1],"of":[2,26,38,51,134,147,158,171],"hyperglycemia":[3,19,30,33,53,85,167,189],"prior":[4],"to":[5,94,182,204,206],"stroke":[6,47],"or":[7,163],"cardiac":[8],"arrest":[9],"can":[10],"increase":[11],"neuronal":[12],"damage":[13],"caused":[14],"by":[15,87,102],"brain":[16,114],"ischemia.":[17],"Acute":[18,156],"shows":[20],"this":[21,71,135,199],"effect":[22,50,136,200],"in":[23,70,78,97,112,178],"animal":[24],"models":[25],"stroke.":[27],"However,":[28],"chronic":[29,32,52,84,119,166,186,207],"and":[31,130,187,195],"with":[34,89,192],"additional":[35],"acute":[36,188],"elevation":[37,157],"blood":[39,57,63],"glucose":[40,104,123,160,180],"are":[41,190],"more":[42],"common":[43],"premorbid":[44],"states":[45],"for":[46,173,198],"patients.":[48],"on":[54,165],"regional":[55,132],"cerebral":[56],"flow":[58,64,145,154,169],"(rCBF)":[59],"is":[60],"unclear":[61],"but":[62],"changes":[65],"may":[66],"play":[67],"a":[68,131,143],"role":[69],"ischemic":[72],"cell":[73],"damage.":[74],"We":[75],"measured":[76,96,111],"rCBF":[77,109,127,194],"awake":[79],"restrained":[80],"rats":[81,98],"that":[82,95],"had":[83],"induced":[86],"treatment":[88],"streptozotocin.":[90],"This":[91],"was":[92,110,124,128,137],"compared":[93],"made":[99],"acutely":[100],"hyperglycemic":[101],"injecting":[103],"into":[105],"the":[106,196],"peritoneal":[107],"space.":[108],"17":[113],"regions":[115,141,151],"using":[116],"[14C]iodoantipyrine.":[117],"During":[118],"hyperglycemia,":[120],"when":[121],"plasma":[122,159,179],"29":[125],"microns/ml,":[126],"decreased":[129,193],"distribution":[133],"noted;":[138],"9":[139],"hindbrain":[140],"showed":[142],"mean":[144],"decrease":[146],"14%":[148],"while":[149],"forebrain":[150],"demonstrated":[152],"less":[153],"reduction.":[155],"during":[161],"normoglycemia":[162],"superimposed":[164],"produced":[168],"reductions":[170],"7%":[172],"each":[174],"10":[175],"microns/ml":[176],"increment":[177],"up":[181],"60":[183],"microns/ml.":[184],"Both":[185],"associated":[191],"mechanism":[197],"does":[201],"not":[202],"appear":[203],"adapt":[205],"hyperglycemia.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}