{"id":"https://openalex.org/W2010007318","doi":"https://doi.org/10.1089/jmf.2009.0258","title":"Allylation of Intraerythrocytic Hemoglobin by Raw Garlic Extracts","display_name":"Allylation of Intraerythrocytic Hemoglobin by Raw Garlic Extracts","publication_year":2010,"publication_date":"2010-06-16","ids":{"openalex":"https://openalex.org/W2010007318","doi":"https://doi.org/10.1089/jmf.2009.0258","mag":"2010007318","pmid":"https://pubmed.ncbi.nlm.nih.gov/20553188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3132946"},"language":"en","primary_location":{"id":"doi:10.1089/jmf.2009.0258","doi":"https://doi.org/10.1089/jmf.2009.0258","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2009.0258","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3132946","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107412810","display_name":"Joseph Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I60388903","display_name":"University of Puerto Rico-Mayaguez","ror":"https://ror.org/00wek6x04","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037","https://openalex.org/I60388903"]}],"countries":["PR","US"],"is_corresponding":false,"raw_author_name":"Joseph Bonaventura","raw_affiliation_strings":["Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA","Department of Chemistry, University of Puerto Rico, Mayag\u00fcez, Puerto Rico","Nicholas School of the Environment, Duke University Marine Laboratory, Beaufort, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Chemistry, University of Puerto Rico, Mayag\u00fcez, Puerto Rico","institution_ids":["https://openalex.org/I60388903"]},{"raw_affiliation_string":"Nicholas School of the Environment, Duke University Marine Laboratory, Beaufort, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110069185","display_name":"Eva N. Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Eva N. Rodriguez","raw_affiliation_strings":["Department of Biology, University of Puerto Rico, San Juan, Puerto Rico","Protein Mass Spectrometry Core Facility, University of Puerto Rico, San Juan, Puerto Rico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]},{"raw_affiliation_string":"Protein Mass Spectrometry Core Facility, University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023724078","display_name":"Veronica Beyley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Veronica Beyley","raw_affiliation_strings":["Department of Biology, University of Puerto Rico, San Juan, Puerto Rico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045479438","display_name":"Irving E. Vega","orcid":"https://orcid.org/0000-0002-7960-9534","observed_orcids":["https://orcid.org/0000-0002-7960-9534"]},"institutions":[{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":true,"raw_author_name":"Irving E. Vega","raw_affiliation_strings":["Department of Biology, University of Puerto Rico, San Juan, Puerto Rico","Protein Mass Spectrometry Core Facility, University of Puerto Rico, San Juan, Puerto Rico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]},{"raw_affiliation_string":"Protein Mass Spectrometry Core Facility, University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045479438"],"corresponding_institution_ids":["https://openalex.org/I200399037"],"apc_list":null,"apc_paid":null,"fwci":0.713,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74745679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"4","first_page":"943","last_page":"949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/garlic-extract","display_name":"garlic extract","score":0.9269999861717224},{"id":"https://openalex.org/keywords/diallyl-disulfide","display_name":"diallyl disulfide","score":0.8560000061988831},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.5249999761581421},{"id":"https://openalex.org/keywords/cysteine-modification","display_name":"cysteine modification","score":0.6299999952316284},{"id":"https://openalex.org/keywords/allylation","display_name":"allylation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/disulfides","display_name":"disulfides","score":0.4950000047683716},{"id":"https://openalex.org/keywords/protein-covalent-modification","display_name":"covalent protein modification","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":0.6510000228881836},{"id":"https://openalex.org/keywords/natural-product-bioactivity","display_name":"natural product bioactivity","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2776488830","wikidata":"https://www.wikidata.org/wiki/Q419633","display_name":"Diallyl disulfide","level":3,"score":0.8149453401565552},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.8065668344497681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7741180658340454},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.700575590133667},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.573516309261322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5545364022254944},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.4515756666660309},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32871565222740173},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14553052186965942},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005737","descriptor_name":"Garlic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/jmf.2009.0258","doi":"https://doi.org/10.1089/jmf.2009.0258","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2009.0258","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3132946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3132946","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Food","raw_type":"Text"},{"id":"pmid:20553188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20553188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal food","raw_type":"Journal Article"},{"id":"pmh:oai:dukespace.lib.duke.edu:10161/3325","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/3325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3132946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3132946","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Food","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2635120155","display_name":"CENTER FOR RESEARCH IN PROTEIN STRUCTURE, FUNCTION AND D","funder_award_id":"P20RR016439","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1899611968","https://openalex.org/W1907341342","https://openalex.org/W1919794947","https://openalex.org/W1933364203","https://openalex.org/W1943303117","https://openalex.org/W1945385519","https://openalex.org/W2003889668","https://openalex.org/W2020599071","https://openalex.org/W2046458713","https://openalex.org/W2071900033","https://openalex.org/W2084647160","https://openalex.org/W2134086699"],"related_works":["https://openalex.org/W4396750614","https://openalex.org/W2023939379","https://openalex.org/W2557726788","https://openalex.org/W2090487927","https://openalex.org/W2020599071","https://openalex.org/W2136309049","https://openalex.org/W7098460466","https://openalex.org/W2074928152","https://openalex.org/W2102835510","https://openalex.org/W2764216712"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2],"shown":[3],"that":[4,63,111,129,171],"deoxygenated":[5,51,69],"human":[6,50,91,163],"red":[7],"blood":[8],"cells":[9],"(RBCs)":[10],"converted":[11],"garlic-derived":[12,130],"polysulfides":[13],"into":[14],"hydrogen":[15],"sulfide,":[16],"which":[17],"in":[18,22],"turn":[19],"produced":[20],"vasorelaxation":[21],"aortic":[23],"ring":[24],"preparations.":[25],"The":[26,60,71],"vasoactivity":[27],"was":[28],"proposed":[29],"to":[30],"occur":[31],"via":[32],"glucose-":[33],"and":[34,53,114,144],"thiol-dependent":[35],"acellular":[36],"reactions.":[37],"In":[38],"the":[39,44,86,100,141,152,156,168],"present":[40],"study,":[41,167],"we":[42],"investigated":[43],"interaction":[45],"of":[46,75,78,85,155,173],"garlic":[47,64,104,112,158,180],"extracts":[48],"with":[49,94],"RBCs":[52],"its":[54],"effect":[55],"on":[56,162],"intracellular":[57,183],"hemoglobin":[58,164],"molecules.":[59],"results":[61,127,169],"showed":[62],"extract":[65,113],"covalently":[66],"modified":[67,117,145],"intraerythrocytic":[68],"hemoglobin.":[70],"modification":[72,102,161],"identified":[73],"consisted":[74],"an":[76],"addition":[77],"71":[79],"atomic":[80],"mass":[81,107],"units,":[82],"suggesting":[83],"allylation":[84],"cysteine":[87],"residues.":[88],"Consistently,":[89],"purified":[90],"deoxyhemoglobin":[92,146],"reacted":[93],"chemically":[95],"pure":[96,136],"diallyl":[97,115,137],"disulfide,":[98],"showing":[99],"same":[101],"as":[103,133,135,177],"extracts.":[105],"Tandem":[106],"spectrometry":[108],"analysis":[109],"demonstrated":[110],"disulfide":[116,138],"hemoglobin's":[118],"beta-chain":[119],"at":[120,147],"cysteine-93":[121],"(beta-93C)":[122],"or":[123,149],"cysteine-112":[124],"(beta-112C).":[125],"These":[126],"indicate":[128,170],"organic":[131],"disulfides":[132],"well":[134],"must":[139],"permeate":[140],"RBC":[142],"membrane":[143],"beta-93C":[148],"beta-112C.":[150],"Although":[151],"physiological":[153],"role":[154],"reported":[157],"extract-induced":[159],"allyl":[160],"warrants":[165],"further":[166],"constituents":[172],"natural":[174],"products,":[175],"such":[176],"those":[178],"from":[179],"extract,":[181],"modify":[182],"proteins.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
