{"id":"https://openalex.org/W2009979068","doi":"https://doi.org/10.4236/abc.2014.41005","title":"N-acetylcysteine amide protects against dexamethasone-induced cataract related changes in cultured rat lenses","display_name":"N-acetylcysteine amide protects against dexamethasone-induced cataract related changes in cultured rat lenses","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2009979068","doi":"https://doi.org/10.4236/abc.2014.41005","mag":"2009979068"},"language":"en","primary_location":{"id":"doi:10.4236/abc.2014.41005","doi":"https://doi.org/10.4236/abc.2014.41005","is_oa":true,"landing_page_url":"https://doi.org/10.4236/abc.2014.41005","pdf_url":"https://content.scirp.org/pdf/abc_2014021014010928.pdf","source":{"id":"https://openalex.org/S2764468471","display_name":"Advances in Biological Chemistry","issn_l":"2162-2183","issn":["2162-2183","2162-2191"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://content.scirp.org/pdf/abc_2014021014010928.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000316027","display_name":"Shakila Tobwala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shakila Tobwala","raw_affiliation_strings":["Department of Chemistry, Missouri University of Science and Technology, Rolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Missouri University of Science and Technology, Rolla, USA","institution_ids":["https://openalex.org/I20382870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040378166","display_name":"Eylem Yaman P\u0131narc\u0131","orcid":"https://orcid.org/0000-0001-8653-043X","observed_orcids":["https://orcid.org/0000-0001-8653-043X"]},"institutions":[{"id":"https://openalex.org/I188740104","display_name":"Ba\u015fkent University","ror":"https://ror.org/02v9bqx10","country_code":"TR","type":"education","lineage":["https://openalex.org/I188740104"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Eylem Y. Pinarci","raw_affiliation_strings":["Department of Ophthalmology, Baskent University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Baskent University, Istanbul, Turkey","institution_ids":["https://openalex.org/I188740104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024358322","display_name":"Yasaswi Maddirala","orcid":"https://orcid.org/0000-0001-5053-2978","observed_orcids":["https://orcid.org/0000-0001-5053-2978"]},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasaswi Maddirala","raw_affiliation_strings":["Department of Chemistry, Missouri University of Science and Technology, Rolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Missouri University of Science and Technology, Rolla, USA","institution_ids":["https://openalex.org/I20382870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006256247","display_name":"Nuran Ercal A","orcid":"https://orcid.org/0000-0001-6188-4274","observed_orcids":["https://orcid.org/0000-0001-6188-4274"]},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nuran Ercal","raw_affiliation_strings":["Department of Chemistry , Missouri University of Science and Technology , Rolla , USA","[Missouri University of Science & Technology]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry , Missouri University of Science and Technology , Rolla , USA","institution_ids":["https://openalex.org/I20382870"]},{"raw_affiliation_string":"[Missouri University of Science & Technology]","institution_ids":["https://openalex.org/I20382870"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1041,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.37855787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"04","issue":"01","first_page":"26","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine-amide","display_name":"N-acetylcysteine amide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucocorticoid-induced-cataract","display_name":"glucocorticoid-induced cataract","score":0.9660000205039978},{"id":"https://openalex.org/keywords/posterior-subcapsular-cataract","display_name":"posterior subcapsular cataract","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lens-opacity","display_name":"lens opacity","score":0.718999981880188},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/thiol-antioxidants","display_name":"thiol antioxidants","score":0.875},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.652999997138977},{"id":"https://openalex.org/keywords/cataract-prevention","display_name":"cataract prevention","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.8743681311607361},{"id":"https://openalex.org/C2780225610","wikidata":"https://www.wikidata.org/wiki/Q127724","display_name":"Cataracts","level":2,"score":0.7324370741844177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4824734032154083},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.46295198798179626},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.46160903573036194},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38046130537986755},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3729701042175293},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3497786521911621},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3305203914642334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26185333728790283},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2610918879508972},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4236/abc.2014.41005","doi":"https://doi.org/10.4236/abc.2014.41005","is_oa":true,"landing_page_url":"https://doi.org/10.4236/abc.2014.41005","pdf_url":"https://content.scirp.org/pdf/abc_2014021014010928.pdf","source":{"id":"https://openalex.org/S2764468471","display_name":"Advances in Biological Chemistry","issn_l":"2162-2183","issn":["2162-2183","2162-2191"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biological Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4236/abc.2014.41005","doi":"https://doi.org/10.4236/abc.2014.41005","is_oa":true,"landing_page_url":"https://doi.org/10.4236/abc.2014.41005","pdf_url":"https://content.scirp.org/pdf/abc_2014021014010928.pdf","source":{"id":"https://openalex.org/S2764468471","display_name":"Advances in Biological Chemistry","issn_l":"2162-2183","issn":["2162-2183","2162-2191"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009979068.pdf","grobid_xml":"https://content.openalex.org/works/W2009979068.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W25013063","https://openalex.org/W25258883","https://openalex.org/W69612348","https://openalex.org/W79732551","https://openalex.org/W130435811","https://openalex.org/W182730751","https://openalex.org/W1498468360","https://openalex.org/W1555079699","https://openalex.org/W1605931247","https://openalex.org/W1891967301","https://openalex.org/W1910418602","https://openalex.org/W1936380547","https://openalex.org/W1971284982","https://openalex.org/W1976462235","https://openalex.org/W1978480627","https://openalex.org/W1981057989","https://openalex.org/W1981494934","https://openalex.org/W1989441559","https://openalex.org/W1991809082","https://openalex.org/W1995527735","https://openalex.org/W1996158201","https://openalex.org/W1998452269","https://openalex.org/W2000142644","https://openalex.org/W2011520923","https://openalex.org/W2014153849","https://openalex.org/W2016439933","https://openalex.org/W2016738431","https://openalex.org/W2018805264","https://openalex.org/W2024174176","https://openalex.org/W2025330205","https://openalex.org/W2026683605","https://openalex.org/W2027737927","https://openalex.org/W2028445408","https://openalex.org/W2029420386","https://openalex.org/W2034745562","https://openalex.org/W2034751609","https://openalex.org/W2038568474","https://openalex.org/W2050438710","https://openalex.org/W2051231986","https://openalex.org/W2052826399","https://openalex.org/W2062099284","https://openalex.org/W2064925671","https://openalex.org/W2065068592","https://openalex.org/W2065741201","https://openalex.org/W2068611987","https://openalex.org/W2073678392","https://openalex.org/W2077868373","https://openalex.org/W2081887594","https://openalex.org/W2082369404","https://openalex.org/W2082937294","https://openalex.org/W2083323622","https://openalex.org/W2083468617","https://openalex.org/W2086334067","https://openalex.org/W2088037458","https://openalex.org/W2088732841","https://openalex.org/W2091287103","https://openalex.org/W2100379789","https://openalex.org/W2103660932","https://openalex.org/W2110131009","https://openalex.org/W2111546909","https://openalex.org/W2114353022","https://openalex.org/W2128068884","https://openalex.org/W2129789095","https://openalex.org/W2133167615","https://openalex.org/W2139783067","https://openalex.org/W2154235553","https://openalex.org/W2158150851","https://openalex.org/W2158571547","https://openalex.org/W2160916653","https://openalex.org/W2171011869","https://openalex.org/W2898286558"],"related_works":["https://openalex.org/W2340734978","https://openalex.org/W4385448529","https://openalex.org/W2322310288","https://openalex.org/W2016738431","https://openalex.org/W2519119447","https://openalex.org/W2519222127","https://openalex.org/W1972251980","https://openalex.org/W1997255017","https://openalex.org/W49093122","https://openalex.org/W4408591385"],"abstract_inverted_index":{"Glucocorticoids":[0],"(GCs)":[1],"are":[2],"one":[3,31],"of":[4,32,43,50,67,74,88,106,201,242],"the":[5,54,72,79,86,124,199,208,211,220,240],"most":[6],"widely":[7],"used":[8],"immunosuppressive":[9],"and":[10,17,46,155,194,196,210,238],"anti-inflammatory":[11],"agents.":[12],"However,":[13],"their":[14],"long":[15],"term":[16],"systemic":[18],"use":[19],"is":[20,39,56,69],"associated":[21],"with":[22,109,144,261],"adverse":[23],"drug":[24],"reactions":[25],"including":[26],"posterior":[27],"subcapsular":[28],"cataracts":[29,76],"as":[30],"its":[33],"ocular":[34],"complications.":[35],"Balanced":[36],"redox":[37],"state":[38],"crucial":[40],"for":[41,163,172,178,198,257],"maintenance":[42],"lens":[44,55],"transparency,":[45],"a":[47,60,89,118,191,252],"high":[48],"content":[49],"glutathione":[51],"(GSH)":[52],"in":[53,63,71,96,206,244],"believed":[57],"to":[58,84,263],"play":[59],"key":[61],"role":[62],"doing":[64],"so.":[65],"Depletion":[66],"GSH":[68],"implicated":[70],"etiopathogenesis":[73],"dexamethasone-induced":[75,98,122],"and,":[77],"therefore,":[78],"present":[80],"study":[81],"was":[82,102],"sought":[83],"evaluate":[85],"efficacy":[87],"novel":[90],"thiol":[91],"antioxidant,":[92],"N-acetylcysteine":[93],"amide":[94],"(NACA),":[95],"preventing":[97],"cataractogenesis.":[99],"Cataract":[100],"formation":[101,233],"induced":[103],"by":[104,167,234],"incubation":[105],"rat":[107,125,204],"lenses":[108,126,205,218],"5":[110,145,168],"\u03bcM":[111,146,152,161,169],"dexamethasone.":[112],"To":[113],"assess":[114],"whether":[115],"NACA":[116,153,157,162,230,247],"had":[117],"significant":[119],"impact":[120],"on":[121],"cataracts,":[123],"were":[127,176,187,214],"divided":[128],"into":[129,251],"four":[130],"groups:":[131],"1)":[132],"control":[133,209],"group":[134,142,150,159,222],"(Dulbecco\u2019s":[135],"Modified":[136],"Eagle":[137],"Medium":[138],"(DMEM),":[139],"2)":[140],"dexamethasone":[141,170],"(DMEM":[143],"dexamethasone),":[147],"3)":[148],"NACA-only":[149,212],"(50":[151,160],"solution),":[154],"4)":[156],"pretreatment":[158],"6":[164],"hours":[165],"followed":[166],"only":[171],"18":[173],"hours).":[174],"Lenses":[175,186],"cultured":[177],"7":[179],"days":[180],"at":[181],"37\u00b0C":[182],"under":[183],"5%":[184],"CO2.":[185],"evaluated":[188],"daily":[189],"using":[190],"dissecting":[192],"microscope":[193],"photographed":[195],"graded":[197],"development":[200],"opacity.":[202],"The":[203],"both":[207],"groups":[213],"clear,":[215],"whereas":[216],"all":[217],"within":[219],"dexamethasone-only":[221],"developed":[223,250],"well-defined":[224],"cataracts.":[225,266],"Overall":[226],"observations":[227],"indicated":[228],"that":[229],"inhibits":[231],"cataract":[232],"limiting":[235],"lipid":[236],"peroxidation":[237],"increasing":[239],"ratio":[241],"GSH/GSSG":[243],"lens.":[245],"Therefore,":[246],"can":[248],"be":[249],"potential":[253],"adjunctive":[254],"therapeutic":[255],"option":[256],"patients":[258],"undergoing":[259],"therapy":[260],"GCs":[262],"inhibit":[264],"glucocorticoid-induced":[265]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}