{"id":"https://openalex.org/W2009940912","doi":"https://doi.org/10.1021/jm970860z","title":"Structure\u2212Activity Relationship of New Growth Inhibitors of Trypanosoma cruzi","display_name":"Structure\u2212Activity Relationship of New Growth Inhibitors of Trypanosoma cruzi","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W2009940912","doi":"https://doi.org/10.1021/jm970860z","mag":"2009940912","pmid":"https://pubmed.ncbi.nlm.nih.gov/9554887"},"language":"en","primary_location":{"id":"doi:10.1021/jm970860z","doi":"https://doi.org/10.1021/jm970860z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm970860z","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024991536","display_name":"G\u00fcendalina M. Cinque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"G\u00fcendalina M. Cinque","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080749101","display_name":"Sergio H. Szajnman","orcid":"https://orcid.org/0000-0001-6989-4768","observed_orcids":["https://orcid.org/0000-0001-6989-4768"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Sergio H. Szajnman","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Li Zhong","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000842323","display_name":"Roberto Docampo","orcid":"https://orcid.org/0000-0003-4229-8784","observed_orcids":["https://orcid.org/0000-0003-4229-8784"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Roberto Docampo","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017242472","display_name":"Andrea J. Schvartzapel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Andrea J. Schvartzapel","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060367228","display_name":"Juan B. Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-5180-096X","observed_orcids":["https://orcid.org/0000-0002-5180-096X"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Juan B. Rodriguez","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082188450","display_name":"Eduardo G. Gros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Eduardo G. Gros","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina, and Laboratory of Molecular Parasitology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61801","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9543,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.84817673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"9","first_page":"1540","last_page":"1554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9710000157356262},{"id":"https://openalex.org/keywords/antiproliferative-agents","display_name":"antiproliferative agents","score":0.9070000052452087},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8169999718666077},{"id":"https://openalex.org/keywords/thiocyanate-derivatives","display_name":"thiocyanate derivatives","score":0.7799999713897705},{"id":"https://openalex.org/keywords/sulfur-compounds","display_name":"sulfur compounds","score":0.8539999723434448},{"id":"https://openalex.org/keywords/epimastigotes","display_name":"epimastigotes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/intracellular-amastigotes","display_name":"intracellular amastigotes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/growth-inhibitors","display_name":"growth inhibitors","score":0.6600000262260437},{"id":"https://openalex.org/keywords/electrophilic-aromatic-substitution","display_name":"electrophilic aromatic substitution","score":0.8270000219345093},{"id":"https://openalex.org/keywords/nifurtimox","display_name":"nifurtimox","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.836875319480896},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.7870216369628906},{"id":"https://openalex.org/C112418997","wikidata":"https://www.wikidata.org/wiki/Q649558","display_name":"Chagas disease","level":2,"score":0.7418692708015442},{"id":"https://openalex.org/C2776171842","wikidata":"https://www.wikidata.org/wiki/Q425300","display_name":"Benznidazole","level":4,"score":0.6209689378738403},{"id":"https://openalex.org/C2776294642","wikidata":"https://www.wikidata.org/wiki/Q77747995","display_name":"Thiocyanate","level":2,"score":0.5863274335861206},{"id":"https://openalex.org/C2781049234","wikidata":"https://www.wikidata.org/wiki/Q411582","display_name":"Nifurtimox","level":4,"score":0.5637903213500977},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.5365170836448669},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5200021862983704},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.49121469259262085},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4822905361652374},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.41953045129776},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.36875414848327637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33357104659080505},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25558799505233765},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15860122442245483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07276025414466858},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009547","descriptor_name":"Nifurtimox","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010647","descriptor_name":"Phenyl Ethers","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010647","descriptor_name":"Phenyl Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010647","descriptor_name":"Phenyl Ethers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013861","descriptor_name":"Thiocyanates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013861","descriptor_name":"Thiocyanates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013861","descriptor_name":"Thiocyanates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014344","descriptor_name":"Trypanocidal Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014344","descriptor_name":"Trypanocidal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014344","descriptor_name":"Trypanocidal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm970860z","doi":"https://doi.org/10.1021/jm970860z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm970860z","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:9554887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9554887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1705444535","display_name":null,"funder_award_id":"AI23259","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1585347147","https://openalex.org/W1966934493","https://openalex.org/W1977602712","https://openalex.org/W1978919433","https://openalex.org/W1980882217","https://openalex.org/W1981565378","https://openalex.org/W1984095340","https://openalex.org/W1986243045","https://openalex.org/W2003390755","https://openalex.org/W2006808855","https://openalex.org/W2020375323","https://openalex.org/W2024100777","https://openalex.org/W2027651316","https://openalex.org/W2031714541","https://openalex.org/W2032388023","https://openalex.org/W2035723109","https://openalex.org/W2054470617","https://openalex.org/W2066655657","https://openalex.org/W2066805289","https://openalex.org/W2067182243","https://openalex.org/W2069607377","https://openalex.org/W2069880401","https://openalex.org/W2071494279","https://openalex.org/W2082071395","https://openalex.org/W2091174068","https://openalex.org/W2094086766","https://openalex.org/W2312770312","https://openalex.org/W2320031123","https://openalex.org/W2322822404","https://openalex.org/W2324943849","https://openalex.org/W2329112904","https://openalex.org/W2333545696","https://openalex.org/W2333757877","https://openalex.org/W2479173975","https://openalex.org/W4253628862"],"related_works":["https://openalex.org/W2080412910","https://openalex.org/W2062895519","https://openalex.org/W2020375323","https://openalex.org/W2039563237","https://openalex.org/W2104479765","https://openalex.org/W2739313970","https://openalex.org/W2766263699","https://openalex.org/W2014310871","https://openalex.org/W2115332332","https://openalex.org/W2035723109"],"abstract_inverted_index":{"Several":[0],"drugs":[1,32,125],"bearing":[2],"the":[3,22,37,61,65,96,110,124,144,148,151,174],"4-phenoxyphenoxy":[4,39],"skeleton":[5],"and":[6,14,102],"other":[7],"closely":[8],"related":[9],"structures":[10],"were":[11,70],"designed,":[12],"synthesized,":[13],"evaluated":[15],"as":[16,53,55,208,214],"antiproliferative":[17,162],"agents":[18,76],"against":[19,77,143,164],"Trypanosoma":[20],"cruzi,":[21],"etiologic":[23],"agent":[24],"of":[25,31,95,99,106,123,147,169,180],"Chagas'":[26],"disease.":[27,133],"The":[28,167],"new":[29],"class":[30],"was":[33,116,137,193],"envisioned":[34],"by":[35,45],"modifying":[36],"nonpolar":[38],"moiety":[40],"replacing":[41],"selected":[42],"aromatic":[43,50],"protons":[44],"different":[46],"groups":[47],"via":[48],"electrophilic":[49],"substitution":[51],"reactions":[52],"well":[54],"introducing":[56],"a":[57,139,170,209,215],"sulfur":[58,155,171],"atom":[59,172,192],"at":[60,150,173],"polar":[62,175],"extreme.":[63],"Of":[64],"designed":[66],"compounds,":[67],"sulfur-containing":[68],"derivatives":[69,156],"shown":[71],"to":[72,88,130,183],"be":[73,89,184],"potent":[74,161],"antireplicative":[75],"T.":[78,100,165],"cruzi.":[79,166],"Among":[80],"these":[81],"drugs,":[82],"4-phenoxyphenoxyethyl":[83],"thiocyanate":[84,135,201],"(compound":[85],"56)":[86],"proved":[87],"an":[90,104],"extremely":[91],"active":[92,119,141],"growth":[93],"inhibitor":[94,142],"epimastigote":[97],"forms":[98],"cruzi":[101],"displayed":[103],"IC50":[105],"2.2":[107],"microM.":[108],"Under":[109],"same":[111],"assay":[112],"conditions,":[113],"this":[114,132,178,191],"drug":[115,211],"much":[117],"more":[118],"than":[120],"Nifurtimox,":[121],"one":[122],"currently":[126],"in":[127],"clinical":[128],"use":[129],"control":[131],"This":[134],"derivative":[136],"also":[138,158,213],"very":[140,160,185,203],"intracellular":[145],"form":[146],"parasite":[149],"nanomolar":[152],"level.":[153],"Other":[154],"prepared":[157],"exhibited":[159],"action":[163,189],"presence":[168],"extreme":[176],"for":[177,187],"family":[179],"compounds":[181],"seems":[182],"important":[186],"biological":[188],"because":[190],"always":[194],"associated":[195],"with":[196],"high":[197],"inhibition":[198],"values.":[199],"4-Phenoxyphenoxyethyl":[200],"presents":[202],"good":[204],"prospective":[205],"not":[206],"only":[207],"lead":[210],"but":[212],"potential":[216],"chemotherapeutic":[217],"agent.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}